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Single Oral Dose Toxicity of TB001 in Rats

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2011, 21(4), pp.41~47
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

Cha Yun Yeop 1,  Seung Ho Sun ORD ID 1,  박원형 1,  박동식 2,  김재현 2,  HeeYeon Kim 3,  임상현 4,  김경희 3

1상지대학교
2농촌진흥청
3강원도 농업기술원
4강원농업기술원

Accredited

ABSTRACT

Objectives :This study was performed to investigate single oral dose toxicity of TB001, the extract mixture of Purple loosestrife and Aceriphyllum rossii. Methods :The mortality, general symptom, change of weight, and necropsy findings was investigated for 14 days after a dose(2000 mg/kg B.W.) of TB001 was given, using SD rats of both male and female according to “The guideline of toxicity test for medicine and others”. Results :The death of rats and abnormal finding was not observed. There was no the significant difference of weight between control group and TB001 group. Conclusions :The abnormalities at the necropsy finding of all survived rats was not detected. The study suggested that there is no toxicity in single dose(2000 mg/kg B.W.) of TB001.

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