Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6
-
pISSN : 1229-1854
- https://journal.kci.go.kr/jkmr
KJCKorea
Journal Central
Effects of Gagamsosokmyeong-tang(Jiajianxiaoxuming-tang ) Treatment on the Monosodium Iodoacetate-induced Early Stage Osteoarthritis in Rats
- Journal of Korean Medicine Rehabilitation
- Abbr : JKMR
- 2011, 21(4), pp.49-65
- Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
- Research Area : Medicine and Pharmacy > Korean Medicine
박동수 1, 정수현 1, Kim， Soon-joong 1, Seo,Il-bok 1
1세명대학교
Accredited
ABSTRACT
Objectives :This study was performed to investigate the effects of Gagamsosokmyeong-tang(Jiajianxiaoxuming-tang) on the monosodium iodoacetate(MIA) induced early stage osteoarthritis in rats.
Methods :Osteoarthritis was induced by injection of MIA(0.25 mg) into knee joints of rats. Osteoarthritic rats were divided into control(n=8) and treated(n=8) group respectively. Control group was taken distilled water and treated group was taken extracts of Gagamsosokmyeong-tang(Jiajianxiaoxuming-tang) by orally for 20 days.
Body weight was measured at 0, 5, 10, 15, 20 days after MIA injection. At the end of experiment, gross and histopathological examination on the articular cartilages of the knee joints were performed. Proteoglycan(PG) content of articular cartilages were analysed by safranine O staining method. The content of tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β) in synovial fluids were analysed by enzyme-linked immunosorbent assay(ELISA) method. And also cyclooxygenase-2(COX-2), matrix metalloproteinase 3(MMP-3), inducible nitric oxide synthase(iNOS), calpain immunohistochemical examination on the knee joints were performed.
Results :PG content in articular cartilages of the treated group was significantly increased compared with control group. Histopathological osteoarthritic score of the treated group was significantly decreased compared with control group. TNF-α content in synovial fluids, expression of iNOS and calpain in synovial membrane of the treated group were significantly decreased compared with control group. But body weight, IL-1β content in synovial fluids, expression of iNOS and MMP-3 of the treated group were not significantly changed compared with control group.
Conclusions :On the basis of these results, we conclude that Gagamsosokmyeong-tang(Jiajianxiaoxuming-tang) has anti-arthritic effects on the MIA induced early stage osteoarthritis in rats.
Statistics
-
346 Viewed
-
1 Downloaded
Tools
Issue List
Citation status
* References for papers published after 2023 are currently being built.
[book]
김진호
/ 2006
/ 재활의학
/ 군자출판사
: 501~524
[book]
한수봉
/ 2006
/ 정형외과학 - 제6판 2권 -
/ 최신의학사
: 253~261
[journal]
이윤종
/ 2004
/ 골관절염의 치료
/ 대한내과학회지
67(5)
: 564~567
[journal]
한성훈
/ 2002
/ 골관절염의 약물치료
/ Inje medical journal
23(4)
: 159~166
[journal]
송영준
/ 2009
/ 골관절염의 치료에서 COX-2 선택적 비스테로이드성 소염진통제의 이용
/ 대한슬관절학회지
21(2)
: 84~92
[book]
한방재활의학과학회
/ 2011
/ 한방재활의학
/ 군자출판사
: 84~98
[book]
孫思邈
/ 1984
/ 備急千金要方
/ 大星出版社
: 155~
[journal]
이경애
/ 1999
/ 小續命湯 추출물이 고지혈증, PC-12 세포독성 및 NO production 에 미치는 영향
/ 韓方成人病學會誌
5(1)
: 123~136
[journal]
이경애
/ 1999
/ 小續命湯 抽出物이 全腦虛血 및 局所腦虛血에 미치는 影響
/ 東國韓醫學硏究所論文集
8(1)
: 107~116
[journal]
조영철
/ 1998
/ 小續命湯이 中腦動脈 閉鎖에 의한 虛血性 腦損傷에 미치는 影響
/ 慶熙韓醫大論文集
21(1)
: 41~54
[journal]
김영균
/ 2000
/ 小續命湯이 白鼠의 局所腦血流量과 혈압血壓에 미치는 影響
/ 대한한방내과학회지
21(5)
: 851~857
[book]
吳謙
/ 1982
/ 醫宗金鑑
/ 人民衛生出版社
: 1046~
[journal]
Janusz MJ
/ 2001
/ Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors
/ Osteoarthritis and Cartilage
9
: 751~760
[book]
許浚
/ 1999
/ 東醫寶鑑
/ 법인문화사
: 950~951
[journal]
Rudolphi K
/ 2003
/ Pralnacasan, an inhibitor of interleukin-1β converting enzyme, reduces joint damage in two murine models of osteoarthritis
/ Osteoarthritis and Cartilage
11(10)
: 738~746
[book]
黃度淵
/ 2002
/ 新增方藥合編
/ 영림사
: 183~
[book]
이상인
/ 1998
/ 한약임상응용
/ 전통의학연구소
: 36~37
[journal]
심상도
/ 1995
/ 구척(구척)이 난소적출로 유발한 흰쥐의 골다공증에 미치는 영향
/ 慶熙韓醫大論文集
24
: 377~386
[journal]
이지영
/ 2010
/
Anti-inflammatory Effect of MeOH Extract of Cibotium barometz in IFN-g and LPS-stimulated Mouse Peritoneal Macrophage
/ 생약학회지
/ 한국생약학회
41(2)
: 108~114
[journal]
임강현
/ 2001
/ 구척이 흰쥐의 장골 길이성장에 미치는 영향
/ 대한본초학회지
16(2)
: 49~55
[journal]
Combe R
/ 2004
/ The monosodium iodoacetate model of osteoarthritis
/ Neurosci Lett
370(2)
: 236~240
[journal]
Guzman RE
/ 2003
/ Mono-iodoacetate-induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis
/ Toxicol Pathol
31(6)
: 619~624
[journal]
Guingamp C
/ 1997
/ Mono-iodoacetate -induced experimental osteoarthritis: a dose- response study of loss of mobility, morphology, and biochemistry
/ Arthritis Rheum
40(9)
: 1670~1679
[journal]
김용문
/ 2008
/
Effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the Monosodium Iodoacetate-induced Osteoarthritis in Rats
/ 한방재활의학과학회지
/ 한방재활의학과학회
18(1)
: 15~32
[journal]
이승헌
/ 2008
/
Effects of GCP Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats
/ 한방재활의학과학회지
/ 한방재활의학과학회
18(1)
: 75~94
[book]
생화학교재편찬위원회
/ 2003
/ 생화학
/ 정문각
: 357~363
[journal]
Shinomura T
/ 2004
/ Proteoglycan knock-out mice and osteoarthritis
/ Clin Calcium
14(7)
: 58~63
[journal]
Chevalier X
/ 2006
/ Targeted anti-cytokine therapies for osteoarthritis
/ Bull Acad Natl Med
190(7)
: 1411~1420
[journal]
Calich AL
/ 2010
/ Osteoarthritis: can anti-cytokine therapy play a role in treatment
/ Clin Rheumatol
29(5)
: 451~455
[book]
박주영
/ 2004
/ 세포분자면역학 5판
/ 범문사
: 243~288
[journal]
Tracey KJ
/ 1987
/ Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
/ Nature
330(6149)
: 662~664
[journal]
Smolen JS
/ 2007
/ New therapies for treatment on rheumatoid arthritis
/ Lancet
370(9602)
: 1861~1874
[journal]
Vilcek J
/ 1991
/ Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions
/ J Biol Chem
266(12)
: 7313~7316
[journal]
Hulejová H
/ 2007
/ Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone
/ Cytokine
38(3)
: 151~156
[journal]
LeGrand A
/ 2001
/ Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci
/ Arthritis Rheum
44(9)
: 2078~2083
[journal]
Kuiper S
/ 1998
/ Different roles of tumour necrosis factor alpha and interleukin 1 in murine streptococcal cell wall arthritis
/ Cytokine
10(9)
: 690~702
[journal]
Needleman P
/ 1997
/ The discovery and function of COX-2
/ J Rheumatol
24(49)
: 6~8
[journal]
Cashman JN
/ 1996
/ The mechanisms of action of NSAIDs in analgesia
/ Drugs
52(5)
: 13~23
[journal]
Anggard E
/ 1994
/ Nitric oxide: mediator, murderer, and medicine
/ Lancet
9
: 1199~1206
[journal]
Vuolteenaho K
/ 2007
/ The role of nitric oxide in osteoarthritis
/ Scand J Rheumatol
36(4)
: 247~258
[journal]
Abramson SB
/ 2001
/ Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis
/ Curr Rheumatol Rep
3(6)
: 535~541
[journal]
Skiles JW
/ 2001
/ The design, structure, and therapeutic application of matrix metalloproteinase inhibitors
/ Curr Med Chem
8
: 425~474
[journal]
Blom AB
/ 2007
/ Crucial role of macrophages in matrix Metalloproteinases-mediated cartilage destruction osteoarthritis: involvement of matrix metalloproteinase 3
/ Arthritis Rheum
56(1)
: 147~157
[journal]
Fujimori Y
/ 1994
/ Immunohistochemical demonstration of calcium-dependent cysteine proteinase(calpain) in collagen-induced arthritis in mice
/ Z Rheumatol
53(2)
: 72~75
[journal]
Yamamoto S
/ 1992
/ Calcium- dependent cysteine proteinase in human arthritic synovial joints
/ Arthritis Rheum
35(11)
: 1309~1317