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@article{ART001654230},
author={Jong-Min Park and 박선옥 and LEE SANG JONG and Shambhunath Bose and 이수진 and Jeon， Song-Hee and 송미영 and Hojun Kim and Myeong-Jong Lee},
title={Effect of Fermented Black Rice Extract on NH4Cl and Acetaminophen-induced Hepatotoxicity},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2012},
volume={22},
number={2},
pages={31-45}

TY - JOUR
AU - Jong-Min Park
AU - 박선옥
AU - LEE SANG JONG
AU - Shambhunath Bose
AU - 이수진
AU - Jeon， Song-Hee
AU - 송미영
AU - Hojun Kim
AU - Myeong-Jong Lee
TI - Effect of Fermented Black Rice Extract on NH4Cl and Acetaminophen-induced Hepatotoxicity
JO - Journal of Korean Medicine Rehabilitation
PY - 2012
VL - 22
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 31
EP - 45
SN - 1229-1854
AB - Objectives :This study was carried out to investigate the hepato-protective effects of fermented black rice(Oryza sativa Linne) extracts(FBRE) through of HepG2 cell and rats. Methods :In vitro, the cell viability, ammonia level, liver enzymes including AST, ALT, GST and SOD were investigated after the treatment of fermented black rice extract(FBRE) and positive controls of commercial nutraceutical products in NH4Cl-treated HepG2 cell lines. In vivo, liver function biomarkers were measured in acetaminophen hepatotoxicity animal model. 32 male rats were divided into four groups and each group were fed different formula for 4 days, i.e, normal control(C), acetaminophen treatment(AA), Hepakhan 250 mg/kg(commercial product as positive control) + acetaminophen treatment(HK+AA), fermented black rice extracts 250 mg/kg + acetaminophen treatment(FBRE+AA). Weight, food intake, liver enzymes, lipid-protein profiles were investigated. Results :In vitro, FBRE and two commercial products(Hepaglucan and Helpkhan) had shown to improve the cell viability, ammonia level, GPT, SOD in HepG2 cell and there were, however, no change on GST, GOT observed. FBRE had shown that similar or better hepato-protective effects than other commercial products. In vivo experiment, there were no significant change in food intake but body weight decreased in all acetaminophen-treatment groups(p<0.05). GPT and glucose level was significantly decreased in FBRE+AA group(p<0.05). Conclusions :These results suggest that FBRE has potential possibility to improve compromised hepatic function.
KW - hepato-protective effects;fermented black rice(Oryza sativa Linne) extracts;HepG2 cell;rats liver cell.
DO -
UR -
ER -

Jong-Min Park, 박선옥, LEE SANG JONG, Shambhunath Bose, 이수진, Jeon， Song-Hee, 송미영, Hojun Kim and Myeong-Jong Lee. (2012). Effect of Fermented Black Rice Extract on NH4Cl and Acetaminophen-induced Hepatotoxicity. Journal of Korean Medicine Rehabilitation, 22(2), 31-45.

Jong-Min Park, 박선옥, LEE SANG JONG, Shambhunath Bose, 이수진, Jeon， Song-Hee, 송미영, Hojun Kim and Myeong-Jong Lee. 2012, "Effect of Fermented Black Rice Extract on NH4Cl and Acetaminophen-induced Hepatotoxicity", Journal of Korean Medicine Rehabilitation, vol.22, no.2 pp.31-45.

Jong-Min Park, 박선옥, LEE SANG JONG, Shambhunath Bose, 이수진, Jeon， Song-Hee, 송미영, Hojun Kim, Myeong-Jong Lee "Effect of Fermented Black Rice Extract on NH4Cl and Acetaminophen-induced Hepatotoxicity" Journal of Korean Medicine Rehabilitation 22.2 pp.31-45 (2012) : 31.

Jong-Min Park, 박선옥, LEE SANG JONG, Shambhunath Bose, 이수진, Jeon， Song-Hee, 송미영, Hojun Kim, Myeong-Jong Lee. Effect of Fermented Black Rice Extract on NH4Cl and Acetaminophen-induced Hepatotoxicity. 2012; 22(2), 31-45.

Jong-Min Park, 박선옥, LEE SANG JONG, Shambhunath Bose, 이수진, Jeon， Song-Hee, 송미영, Hojun Kim and Myeong-Jong Lee. "Effect of Fermented Black Rice Extract on NH4Cl and Acetaminophen-induced Hepatotoxicity" Journal of Korean Medicine Rehabilitation 22, no.2 (2012) : 31-45.

Jong-Min Park; 박선옥; LEE SANG JONG; Shambhunath Bose; 이수진; Jeon， Song-Hee; 송미영; Hojun Kim; Myeong-Jong Lee. Effect of Fermented Black Rice Extract on NH4Cl and Acetaminophen-induced Hepatotoxicity. Journal of Korean Medicine Rehabilitation, 22(2), 31-45.

Jong-Min Park; 박선옥; LEE SANG JONG; Shambhunath Bose; 이수진; Jeon， Song-Hee; 송미영; Hojun Kim; Myeong-Jong Lee. Effect of Fermented Black Rice Extract on NH4Cl and Acetaminophen-induced Hepatotoxicity. Journal of Korean Medicine Rehabilitation. 2012; 22(2) 31-45.

Jong-Min Park, 박선옥, LEE SANG JONG, Shambhunath Bose, 이수진, Jeon， Song-Hee, 송미영, Hojun Kim, Myeong-Jong Lee. Effect of Fermented Black Rice Extract on NH4Cl and Acetaminophen-induced Hepatotoxicity. 2012; 22(2), 31-45.

Jong-Min Park, 박선옥, LEE SANG JONG, Shambhunath Bose, 이수진, Jeon， Song-Hee, 송미영, Hojun Kim and Myeong-Jong Lee. "Effect of Fermented Black Rice Extract on NH4Cl and Acetaminophen-induced Hepatotoxicity" Journal of Korean Medicine Rehabilitation 22, no.2 (2012) : 31-45.