The Effects of ST36, GB34, GB39 and Hyeopcheok Points on Nerve Regeneration in Spinal Cord Injury Rat Model (족삼리, 양릉천, 현종과 협척혈이 척수 압좌 손상 모델의 신경 재생에 미치는 영향)

Mi-Sung Yang (양미성); 기영범; 강대희; Misook Shin (신미숙); Kim Seon Jong (김선종); choi jin bong (최진봉)

The Effects of ST36, GB34, GB39 and Hyeopcheok Points on Nerve Regeneration in Spinal Cord Injury Rat Model

Journal of Korean Medicine Rehabilitation
Abbr : JKMR
2012, 22(4), pp.1-21
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

Mi-Sung Yang ¹, 기영범 ², 강대희 ², Misook Shin ³, Kim Seon Jong ⁴, choi jin bong ⁴

¹동신대학교 한의과대학 재활의학과교실
²동신대학교 한의과대학 한방재활의학과
³부산대학교
⁴동신대학교

Accredited

ABSTRACT

Objectives :The purpose of this study was to investigate the effects of ST36, GB34 and GB39, Hyeopcheok points, electrical acupuncture and acupuncture on nerve regeneration and neuromuscular synaptic reorganization in rat model of spinal cord injury(SCI). Methods :The subjects were divided into 5 groups; control group with no treatment after inducing SCI, experimental group Ⅰ taken with acupuncture of Hyeopcheok points after inducing SCI, experimental group Ⅱ taken with acupuncture of ST36, GB34 and GB39 after inducing SCI, experimental group Ⅲ taken with electrical acupuncture of Hyeopcheok points after inducing SCI and experimental group Ⅳ taken with electrical acupuncture of ST36, GB34 and GB39 after inducing SCI. After each operation, the present author observed cytological changes, the motor behavior recovery and nerve regeneration by analysis of the motor behavior tests, histological and immunological changes. Rats were tested at modified Tarlov test at the 1st day, Basso, Beattle, Bresnahan locomotor rating scale(BBB scale) at the 3rd, 7th, 14th and 21 days. Results :1. Experimental group Ⅳ were improved compared with control group, experimental group Ⅰ, Ⅱ, Ⅲ in the motor behavior test(BBB scale). 2. BDNF(brain-derived neurotrophin factor) expression degree in the SCI tissue of all the experimenral groups were increased compared with control group. Especially, those of experimental group Ⅳ was more effective. 3. Muscular atrophy in gastrocnemius were restored only in experimental group Ⅳ. 4. NT-3(neurotrophin-3) expression degree in the SCI inducing rats of all the experimenral groups were increased compared with control group. Especially, those of experimental group Ⅳ was more effective. Conclusions :It can be suggested that electrical acupuncture of ST36, GB34 and GB39 may improve motor behavior, histological and immunological findings in SCI-induced rats compared with acupuncture of ST36, GB34 and GB39, acupuncture or electrical acupuncture of Hyeopcheok points.

KEYWORDS

Hyeopcheok points, ST36, GB34, GB39, Electrical acupuncture, Spinal cord injury

Citation status

* References for papers published after 2023 are currently being built.

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