2012, Vol.22, No.4

The Effects of ST36, GB34, GB39 and Hyeopcheok Points on Nerve Regeneration in Spinal Cord Injury Rat Model

Mi-Sung Yang , 기영범 , 강대희 and 3 other persons | 2012, 22(4) | pp.1~21 | number of Cited : 5

Objectives :The purpose of this study was to investigate the effects of ST36, GB34 and GB39, Hyeopcheok points, electrical acupuncture and acupuncture on nerve regeneration and neuromuscular synaptic reorganization in rat model of spinal cord injury(SCI). Methods :The subjects were divided into 5 groups; control group with no treatment after inducing SCI, experimental group Ⅰ taken with acupuncture of Hyeopcheok points after inducing SCI, experimental group Ⅱ taken with acupuncture of ST36, GB34 and GB39 after inducing SCI, experimental group Ⅲ taken with electrical acupuncture of Hyeopcheok points after inducing SCI and experimental group Ⅳ taken with electrical acupuncture of ST36, GB34 and GB39 after inducing SCI. After each operation, the present author observed cytological changes, the motor behavior recovery and nerve regeneration by analysis of the motor behavior tests, histological and immunological changes. Rats were tested at modified Tarlov test at the 1st day, Basso, Beattle, Bresnahan locomotor rating scale(BBB scale) at the 3rd, 7th, 14th and 21 days. Results :1. Experimental group Ⅳ were improved compared with control group, experimental group Ⅰ, Ⅱ, Ⅲ in the motor behavior test(BBB scale). 2. BDNF(brain-derived neurotrophin factor) expression degree in the SCI tissue of all the experimenral groups were increased compared with control group. Especially, those of experimental group Ⅳ was more effective. 3. Muscular atrophy in gastrocnemius were restored only in experimental group Ⅳ. 4. NT-3(neurotrophin-3) expression degree in the SCI inducing rats of all the experimenral groups were increased compared with control group. Especially, those of experimental group Ⅳ was more effective. Conclusions :It can be suggested that electrical acupuncture of ST36, GB34 and GB39 may improve motor behavior, histological and immunological findings in SCI-induced rats compared with acupuncture of ST36, GB34 and GB39, acupuncture or electrical acupuncture of Hyeopcheok points.

Acupuncture's Efficacy and Safety in Axial Spondyloarthritis within 4 Weeks Session : a Randomized, Double-blind, Sham-controlled Trial

조종현 , 권정주 , SONG YUN KYUNG and 2 other persons | 2012, 22(4) | pp.23~36 | number of Cited : 2

Effects of Kamchobuja-tang(Gancaofuzi-tang ) on Papain-Induced Osteoarthritis in Mice

최재영 , Minseok Oh | 2012, 22(4) | pp.37~57 | number of Cited : 7

Objectives :This study intends to clarify how Kamchobuja-tang(Gancaofuzi-tang, here in after referred to KBT) affect mice of C57BL/10 whose osteoarthritis was induced by papain. Methods :Osteoarthritis was induced into mice by injecting papain in its knee joint. Mice are divided into a total of 4 groups(n=6). Normal group are not treated at all without inducing osteoarthritis whereas control group(OAC-control) were induced for osteoarthritis by papain and oral medicated with 200 ul of physiological saline per day. Positive comparison group(OAC-Joins®) was injected with papain and after 7 days, 100 mg/kg of Joins® was medicated with 200 ul of physiological saline mixed. Experimental group(OAC-KBT) was injected with papain and after 7 days that was medicated with 400 mg/kg of KBT mixed with 200 ul of physiological saline. OAC-Joins® and OAC-KBT were oral medicated for each substance a total of 4 weeks with one time per day. After experiments(from 1 week after injection of papain to 4 weeks elapsed), the functions of liver and kidney, inflammation cytokine values within serum, degree of revelation for inflammation cytokine genes, immune cells within blood, metabolism of arachidonic acid and amount of cartilage were measured and histopathological variations for knee joint structures were observed. Results :1. Functions of liver and kidney were not affected. 2. IL-6((interleukin-6), IL-1β(interleukin-1β), MCP-1(monocyte chemoattra- ctant protein-1) and TNF-α(tumor necrosis factor-α) are meaningfully reduced. 3. After analyzing inflammation cytokine in joints with mRMA(messenger ribonucleic acid), revelation of IL-1β, IL-6 and iNOS-Ⅱ(inducible nitric oxide synthase-Ⅱ) were all meaningfully reduced. And revelation of TNF-α and COX-2 gene were also reduced but meaningless. 4. Neutrophil and monocyte for WBC(white blood cell) within serum were meaningfully reduced. 5. PGE2(prostaglandin E2), TXB2(thromboxane B2) and LTB4(leukotriene B4) were meaningfully reduced. 6. Destruction of cartilage on micro CT(computed tomography)-arthrography was meaningfully reduced. 7. In terms of histopathology, infiltration of inflammation, proliferation of synovial membrane, subsidence of cartilage and bone due to penetration of excessive formation of synovial cell and destruction of cartilage were small(H&E(hematoxylin and eosin), Safranine-O staining). Conclusions :Based on all results mentioned above, KBT is believed to be meaningful for suppressing the progress of osteoarthritis and its treatments because of its anti-inflammatory effects and alleviation of pain with histopathological effective efficacy.

Anti-OsteoArthritic effects of Mahwangbuja-tang(Mahuangfuzi-tang ) on Papain-Induced OsteoArthritic mice model

장효길 , Dongseok Heo | 2012, 22(4) | pp.59~77 | number of Cited : 4

Objectives :This study was to investigate the anti-osteoarthritic effects of Mahwangbuja-tang(Mahuangfuzi-tang, MBT) on the papain-induced osteoarthritis. Methods :Arthritis was induced by injection of papain into knee joints of rats. Arthritic rats were divided into four groups(Normal, control, JoinsⓇ, MBT). Control group was taken distilled water for 4 weeks and the MBT group, extracts of MBT by orally for 4 weeks. At the end of the experiment(5 weeks after papain injection), micro CT arthrography and histopathological examinations on the articular structures of knee joint were performed. The effect on inflammatory cytokine, immunological cell in synovial fluid was measured. Gene expressions of inflammatory cytokine in synovial fluid were measured by PCR. Volume of cartilage was measured by micro CT arthrography. Injury of synovial tissue was measured by H&E, safranin-O imunofluorescence. Results :1. IL-6, MCP-1, TNF-α were decreased significantly and IL-1β was decreased in MBT group. 2. Thromboxane B2, Leukotriene B4, prostaglandin E2 were decreased significantly in MBT group. 3. Neutrophil was decreased significantly and white blood cell, monocyte was decreased in MBT group. 4. IL-1β mRNA, iNOS-Ⅱ mRNA were decreased significantly and IL-6 mRNA, TNF-α mRNA, COX-2 mRNA were decreased in MBT group . 5. Through micro CT arthrography, volume of cartilage was increased significantly in MBT group. 6. Histopathologically, injury on synovial membrane of MBT group was decreased and proteoglycan content of MBT group was increased. Conclusions :According to this study, Mahwangbuja-tang has inhibiting effect on the progression of arthritis in papain-induced osteoarthritis model. And it is related to inhibiting the activity of inflammatory cytokine and its gene expression in osteoarthritic chondrocytes and injury of volume in cartilage.

The Effects of Bee Venom Therapy with Different Dose in Neuropathic Pain Rat Model

박민정 , Seung-ryong Yeom , Young Dal Kwon | 2012, 22(4) | pp.79~89 | number of Cited : 2

목적 :본 실험은 신경병증성 동통에 대한 농도별 처치 조건에 따른 봉독 약침의 치료 효과를 알아보기 위한 연구이다. 방법 :L5 신경을 결찰하여 신경병증성 동통이 유발된 75마리의 흰 쥐 모델을 대상으로 동통 유발 후 7일째부터 이틀에 한번씩, 총 18일 동안 環跳穴(GB30)에 정해진 용량의 봉독약침을 주입하는 방식으로 이루어졌다. 실험을 위해 대조군은 신경병증성 동통 유발 후 동량의 생리식염수만 처치한 군(n=25), 봉독 처치군 Ⅰ은 점진적으로 일정하게 농도를 증가시켜 처치한 군(n=25, 1.67×10-3 mg/kg 부터 8.35×10-3 mg/kg까지, 총 주입량 3.22×10-2 mg/kg), 봉독 처치 군 Ⅱ는 일정하게 농도를 유지시켜 처치한 군(n=25, 3.58×10-3 mg/kg, 총 주입량 3.22×10-2 mg/kg)으로 나누었다. 치료효과를 알아보기 위해 기계적, 열적 자극에 대한 회피반응 역치뿐만 아니라 신경전도속도 검사, 척수후각의 c-Fos 면역조직화학적 반응이 분석되었다. 결과 :실험 결과 기계적, 열적 자극에 대한 통증행동학적 평가와 c-Fos 면역조직화학적 반응에서 봉독 처치군 I은 봉독 처치군 Ⅱ에 비해 봉독약침 처치 초반부터 더 나은 진통효과를 나타냈고, 신경전도속도 검사에서 봉독 처치군 Ⅱ는 봉독 처치군 I에 비해 봉독약침 처치 초반부터 더 나은 신경전도의 회복을 나타냈다. 그러나 처치 후반에는 두 봉독 처치군 모두 비슷한 진통효과를 나타냈다. 결론 :봉독약침 치료는 신경병증성 동통에 매우 효과적임을 알 수 있었고 봉독의 총 처치량이 같은 상태에서 일정하게 봉독의 농도를 증가시키는 방법과 일정하게 봉독의 농도를 유지시키는 방법은 유사한 치료 효과가 있었음을 알 수 있었다.

A Study for Meta-analysis of the Efficacy of Acupuncture Treatment for Low Back Pain for Oriental Medicine Clinical Practice Guideline

Man-Jin Jeong , 권오곤 , Chang-Hoon Woo and 1 other persons | 2012, 22(4) | pp.91~98 | number of Cited : 2

The Latest Trends of Chuna Treatment on Low Back Pain in PubMed

최희승 , 엄봉군 , 김주영 and 3 other persons | 2012, 22(4) | pp.99~113 | number of Cited : 4

A Comparative Study of Improvement of Pain and Physical Function According to Cervical Spine Curvature in Patients of Neck Pain Caused by Traffic Accident

김선민 , 김지용 , 전병철 | 2012, 22(4) | pp.115~122 | number of Cited : 1

A Study of the Relationship Between Fear-Avoidance Beliefs, Pain and Neck Disability Index in Patients with Neck Pain

김성식 , Chung eun jung , Jongsoo Lee and 1 other persons | 2012, 22(4) | pp.123~133 | number of Cited : 4

The Change of Cervical Curvature in Whiplash Injury Patients after Oriental Medicine Treatment

Eun-Sill Choi , Honggyu Jang , 권오곤 and 2 other persons | 2012, 22(4) | pp.135~145 | number of Cited : 2

A Case Report of Oriental Medical Treatment for Obesity on Overweight and Obese Children of Broken Home

박민정 , Young Dal Kwon , Seung-ryong Yeom and 3 other persons | 2012, 22(4) | pp.147~156 | number of Cited : 2

The Association of the Nutritional Status and Physique Development Degree with BMI in Health Checkup Examinees of College Students in Seongnam

안민윤 , 염도성 , 강형구 and 3 other persons | 2012, 22(4) | pp.157~167 | number of Cited : 0

The Analysis of 509 Admission Patients in Korean Medical Hospital due to Traffic Accident

국길호 , Minseok Oh | 2012, 22(4) | pp.169~183 | number of Cited : 12

Two Clinical Cases of Heating-conduction Acupuncture Therapy and Needle-embedding Therapy Combined with Oriental Medical Treatments for Ankle Ligament Injury

이현재 , 국길호 , LEE EUN JUNG and 2 other persons | 2012, 22(4) | pp.185~198 | number of Cited : 12

A Clinical Case of the Korean and Western Medical Treatment for the Patient with Herpes Zoster Opthalmicus

민선정 , 박민정 , 유경곤 and 2 other persons | 2012, 22(4) | pp.199~207 | number of Cited : 3

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Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6

2012, Vol.22, No.4