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Effects of Samki-eum (sānqì-yǐn) on Freund’s Complete Adjuvant-induced Arthritic Rats

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2013, 23(3), pp.1-14
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

최은실 1,  Honggyu Jang 1,  권오곤 1,  Chang-Hoon Woo 1,  Hee Duk An 1

1대구한의대학교

Accredited

ABSTRACT

Objectives The object of this study was to observe the favorable anti-arthritic effects ofSamki-eum (sānqì-yǐn) on Freund’s complete adjuvant (FCA)-induced arthritic Wistar rats. Methods Rheumatoid arthritis was induced by intradermal injection of FCA, and 300,150 or 750 mg/kg of Samki-eum (sānqì-yǐn) were orally administered once a day for 14days from 14 days after FCA treatments, and 15 mg/kg of dexamethasone was intraperitoneallyadministered as reference drug in this experiment. All rats were sacrificed at14 days after continuous oral treatment of Samki-eum (sānqì-yǐn) or intraperitoneal administrationof dexamethasone, and changes on the body weight, knee circumferences, grossarthritis score, inflammatory tissue prostaglandin (PG) E2 levels were monitored with cartilagecollagen components and glucosaminoglycans compositions - chondroitin sulphate,heparan sulphate and hyaluronic acid in the present study. Results As results of FCA treatment, classic rheumatoid arthritis featuring dramaticaldecreases on the body weights, cartilage collagen contents and bone glucosaminoglycans-chondroitin sulphate, heparan sulphate and hyaluronic acid contents, with increaseson the knee circumferences, gross arthritis scores and inflammatory tissue PGE2 levels. However, these changes from FCA-induced rheumatoid arthritis were clearly reduced bytreatment of dexamethasone and both two different dosages of Samki-eum (sānqì-yǐn)300 and 150 mg/kg in the present study. Although FCA-induced arthritis were more favorablyinhibited by treatment of dexamethasone 15 mg/kg as compared with Samki-eum(sānqì-yǐn) 300 mg/kg, marked decreases of body weights were detected in dexamethasone15 mg/kg treated rats, and Samki-eum (sānqì-yǐn) 300 mg/kg showed similarpreserve effects on the cartilage glucosaminoglycan compositions in this study. Conclusions The results obtained in this study suggest that over 300 and 150 mg/kg ofSamki-eum (sānqì-yǐn) showed favorable anti-arthritic effects on the FCA-induced arthritismediated by suppression of PGE2, a inflammatory mediator. However, detail mechanismstudies should be conduced in future with the screening of the biological active compoundsin this herb. Although overall anti-inflammatory effects Samki-eum (sānqì-yǐn) 300mg/kg were lowered than those of dexamethasone 15 mg/kg treated rats, Samki-eum(sānqì-yǐn) 300 mg/kg treated rats showed similar preserve effects on the cartilage glucosaminoglycancompositions in this experiment.

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