본문 바로가기
  • Home

Antibacterial Effect of Huanggeumjakyak-tang against Methicillin-resistant Staphylococcus aureus

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2013, 23(3), pp.15-26
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

김에스더 1 최종환 2 김일현 2 이하일 2 SONG YUNG SUN 1

1원광대학교
2원광대학교 한의과대학 한방재활의학과교실

Accredited

ABSTRACT

Objectives The aim of this study was to investigate antimicrobial activity of Huanggeumjakyak-tang water extract against MRSA. Methods The antibacterial activities of Huanggeumjakyak-tang were evaluated against3 strains of Methicillin-resistant Staphylococcus aureus (MRSA) and 1 standard MethicillinsusceptibleS. aureus (MSSA) strain by using the disc diffusion method, minimal inhibitoryconcentrations (MICs) assay, colorimetric assay using MTT test, checkerboard dilutiontest and time-kill assay was performed under dark. Results The MIC (minimum inhibitory concentration) of Huanggeumjakyak-tang waterextract against S. aureus strains ranged from 1,000 to 2,000μg/ml. So we confirmed thatit has a strong antibacterial effect. Also the combinations of Huanggeumjakyak-tang waterextract and conventional antibiotics exhibited improved inhibition of MRSA with synergyeffect. Conclusions The results obtained in this study suggest that Huanggeumjakyak-tangwater extract showed antibacterial effect against MRSA, and it also showed reducing effecton the side-effect problems that are the major weak points of traditional antibiotics.

Citation status

* References for papers published after 2023 are currently being built.