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Effects of Yuhyangjeongtong-san on the Carrageenin-induced Acute Inflammation and Adjuvant-induced Arthritis

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2013, 23(3), pp.55-68
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

안희빈 1 Jeong, Su-hyeon 2 Kim, Soon-joong 2 박동수 2 Seo,Il-bok 2

1더필립요양병원
2세명대학교

Accredited

ABSTRACT

Objectives This study was to investigate the effects of Yuhyangjeongtong-san on thecarrageenin-induced acute inflammation and adjuvant-induced arthritis in rats. Methods Acute inflammation was induced by injection of 2% carrageenin 0.15 ml intoright hind foot of rats. Control group was carrageenin injected and taken distilled water,treated group was carrageenin injected and taken Yuhyangjeongtong-san by orally once. 2 hours after injection, plantar temperature and paw volume were measured. 3 hours after,counts of white blood cell (WBC) were performed. Arthritis was induced by injection ofcomplete freund’s adjuvant (CFA) into base of tail. Control group was CFA injected andtaken distilled water, treated group was CFA injected and taken Yuhyangjeongtong-san byorally for 10 days. 0,5,10 day, body weight, thickness of ankle joint and paw edema weremeasured. 10 day, counts of WBC, interleukin-1β (IL-1β) and tumor necrosis factor-α(TNF-α) level were analysed. Histochemical study of NADPH-d and immunohistochemicalstudy of c-fos were performed. Results In the carrageenin-induced acute inflammation, neutrophils of treated groupwere significantly decreased compared with control group. In the adjuvant-induced arthritis,paw edema, total counts of WBC and TNF-α level in paw exudates were significantlydecreased compared with control group, and the number of c-fos positive neurons oftreated group was significantly decreased compared with control group. Conclusions On the basis of these results, we concluded that Yuhyangjeongtong-sanhave anti-arthritic and anti-inflammatory effects.

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