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@article{ART001792267},
author={이수연 and 박원형 and Cha Yun Yeop and 이은},
title={Effects of Ojeoksangamibang Extract on the Recovery of Liver Function in CCl4-exposed Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2013},
volume={23},
number={3},
pages={45-53}

TY - JOUR
AU - 이수연
AU - 박원형
AU - Cha Yun Yeop
AU - 이은
TI - Effects of Ojeoksangamibang Extract on the Recovery of Liver Function in CCl4-exposed Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2013
VL - 23
IS - 3
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 45
EP - 53
SN - 1229-1854
AB - Objectives The objective of present study was to investigate the effect of Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) extract on recovery of liver function in carbontetrachloride(CCl4)-exposed rat. Methods Male rats weighing 230±7.21 g fed experimental diet for 1 week and 28 ratswere divided into 4 groups. Each of 7 rats was devided into a control group and experimentalgroups. We fed a control group of rats a basal diet and administered normalsaline (100 mg/kg, 1 time/1 day) for 3 weeks. And we fed each experimental group of ratsbasal diet and administered an extract of Ojeoksangamibang extracts (100 mg/kg, 200mg/kg, 300 mg/kg, 1 time/1 day) for 3 weeks. We measured lipid of plasma and liver, concentrationof proinflammatory cytokines (IL-1β, TNF-α, IL-6 and IL-10). Statistical analysiswas done by one-way analysis of variance (ANOVA) and Duncan's multiple range testwith significance level at p＜0.05. Results Plasma a-fetoprotein (AFP) and total protein concentration showed a tendencyto decrease in Ojeoksangamibang extract-treated groups. However, plasma albumin concentrationshowed no significant differences in all treatment groups. Activity of plasmaAspartate aminotransferase (AST) and Alanine aminotransferase (ALT) in the Ojeoksangamibangextract-treated groups, increased addition amount of Ojeoksangamibang extractstended to decline. Alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and γ-glutamyltransferase (γ-GT) activities showed a tendency to decrease in Ojeoksangamibangextract-treated groups, increased addition amount of Ojeoksangamibang extracts tendedto decline. Concentration of plasma triglyceride and total cholesterol showed a lower valuethan that of control group. The liver IL-1β, IL-6 and TNF-α concentration were decreased,and IL-10 was increased in Ojeoksangamibang extract groups, compared tocontrol group. Plasma IL-1β, IL-6 and TNF-α concentration were decreased, and IL-10was increased in Ojeoksangamibang extract groups, compared to control group. Conclusions This study suggested that Ojeoksangamibang may alleviate liver inflammatoryreaction induced by liver toxicity.
KW - Ojeoksangamibang extract;Liver function;A-fetoprotein;AST;ALT;Cytokines
DO -
UR -
ER -

이수연, 박원형, Cha Yun Yeop and 이은. (2013). Effects of Ojeoksangamibang Extract on the Recovery of Liver Function in CCl4-exposed Rats. Journal of Korean Medicine Rehabilitation, 23(3), 45-53.

이수연, 박원형, Cha Yun Yeop and 이은. 2013, "Effects of Ojeoksangamibang Extract on the Recovery of Liver Function in CCl4-exposed Rats", Journal of Korean Medicine Rehabilitation, vol.23, no.3 pp.45-53.

이수연, 박원형, Cha Yun Yeop, 이은 "Effects of Ojeoksangamibang Extract on the Recovery of Liver Function in CCl4-exposed Rats" Journal of Korean Medicine Rehabilitation 23.3 pp.45-53 (2013) : 45.

이수연, 박원형, Cha Yun Yeop, 이은. Effects of Ojeoksangamibang Extract on the Recovery of Liver Function in CCl4-exposed Rats. 2013; 23(3), 45-53.

이수연, 박원형, Cha Yun Yeop and 이은. "Effects of Ojeoksangamibang Extract on the Recovery of Liver Function in CCl4-exposed Rats" Journal of Korean Medicine Rehabilitation 23, no.3 (2013) : 45-53.

이수연; 박원형; Cha Yun Yeop; 이은. Effects of Ojeoksangamibang Extract on the Recovery of Liver Function in CCl4-exposed Rats. Journal of Korean Medicine Rehabilitation, 23(3), 45-53.

이수연; 박원형; Cha Yun Yeop; 이은. Effects of Ojeoksangamibang Extract on the Recovery of Liver Function in CCl4-exposed Rats. Journal of Korean Medicine Rehabilitation. 2013; 23(3) 45-53.

이수연, 박원형, Cha Yun Yeop, 이은. Effects of Ojeoksangamibang Extract on the Recovery of Liver Function in CCl4-exposed Rats. 2013; 23(3), 45-53.

이수연, 박원형, Cha Yun Yeop and 이은. "Effects of Ojeoksangamibang Extract on the Recovery of Liver Function in CCl4-exposed Rats" Journal of Korean Medicine Rehabilitation 23, no.3 (2013) : 45-53.