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Effects of Ojeoksangamibang Extract on the Recovery of Liver Function in CCl4-exposed Rats

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2013, 23(3), pp.45-53
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

이수연 1 박원형 2 Cha Yun Yeop 2 이은 1

1상지대학교 보건과학대학 제약공학과
2상지대학교

Accredited

ABSTRACT

Objectives The objective of present study was to investigate the effect of Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) extract on recovery of liver function in carbontetrachloride(CCl4)-exposed rat. Methods Male rats weighing 230±7.21 g fed experimental diet for 1 week and 28 ratswere divided into 4 groups. Each of 7 rats was devided into a control group and experimentalgroups. We fed a control group of rats a basal diet and administered normalsaline (100 mg/kg, 1 time/1 day) for 3 weeks. And we fed each experimental group of ratsbasal diet and administered an extract of Ojeoksangamibang extracts (100 mg/kg, 200mg/kg, 300 mg/kg, 1 time/1 day) for 3 weeks. We measured lipid of plasma and liver, concentrationof proinflammatory cytokines (IL-1β, TNF-α, IL-6 and IL-10). Statistical analysiswas done by one-way analysis of variance (ANOVA) and Duncan's multiple range testwith significance level at p<0.05. Results Plasma a-fetoprotein (AFP) and total protein concentration showed a tendencyto decrease in Ojeoksangamibang extract-treated groups. However, plasma albumin concentrationshowed no significant differences in all treatment groups. Activity of plasmaAspartate aminotransferase (AST) and Alanine aminotransferase (ALT) in the Ojeoksangamibangextract-treated groups, increased addition amount of Ojeoksangamibang extractstended to decline. Alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and γ-glutamyltransferase (γ-GT) activities showed a tendency to decrease in Ojeoksangamibangextract-treated groups, increased addition amount of Ojeoksangamibang extracts tendedto decline. Concentration of plasma triglyceride and total cholesterol showed a lower valuethan that of control group. The liver IL-1β, IL-6 and TNF-α concentration were decreased,and IL-10 was increased in Ojeoksangamibang extract groups, compared tocontrol group. Plasma IL-1β, IL-6 and TNF-α concentration were decreased, and IL-10was increased in Ojeoksangamibang extract groups, compared to control group. Conclusions This study suggested that Ojeoksangamibang may alleviate liver inflammatoryreaction induced by liver toxicity.

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