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Effects of Bee Venom Extract Pharmacopuncture on the Regional Cerebral Blood Flow and Mean Blood Pressure in Rats

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2013, 23(3), pp.37-44
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

민선정 1,  Seung-ryong Yeom 2,  Young Dal Kwon 2

1원광대학교 한의과대학 한방재활의학과교실
2원광대학교

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ABSTRACT

Objectives The present study was designed to investigate the effects of bee venom extractpharmacopunctureon (BVP) at 肩井 (GB21) on the changes in regional cerebral bloodflow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and further to determinethe mechanisms. Methods We purchased rats about 300g and prepared diluted BVP with normal saline. And we injected diluted BVP to rats gradually progressed from 0.001 mg/kg to 0.1 mg/kgat corresponding region to GB21. After injection, we measured the changes in rCBF andMABP of rats. In addition, to determine the mechanisms of this changes, we did the sameexperiments twice more after pretreatment with indomethacin and metylene blue separately. Results BVP significantly increased rCBF but decreased MABP, suggesting that BVPpotently may increase rCBF by dilating pial arterial diameter. Furthermore, the increase ofBVP-induced rCBF and the decrease of BVP-induced MABP were significantly blocked bypretreatment with cyclooxygenase inhibitor, indomethacin (1 mg/kg, i.p.). But the increaseof BVP-induced rCBF and the decrease of BVP-induced MABP were not blocked by pretreatmentwith guanylate cyclase inhibitor, methylene blue (0.01 mg/kg, i.p.). Conclusions These findings indicate that the action of BVP is mediated by cyclooxygenase. Furthermore these results suggest that BVP can increase rCBF in normal state, aswell as improve the stability of rCBF in ischemic state.

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