Effects of Fermented Lotus Extracts on Glucose Intolerance and Lipid Metabolism-related Gene Expression (연잎-연근 복합 발효물이 흰쥐의 내당능 및 지질대사 관련 유전자 발현에 미치는 영향)

김형구; Shambhunath Bose (보세); Kim, Dong il (김동일); Byung-soo Koo (구병수); Hojun Kim (김호준)

Effects of Fermented Lotus Extracts on Glucose Intolerance and Lipid Metabolism-related Gene Expression

Journal of Korean Medicine Rehabilitation
Abbr : JKMR
2014, 24(1), pp.1-12
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

김형구 ¹, Shambhunath Bose ², Kim, Dong il ², Byung-soo Koo ², Hojun Kim ²

¹동국대학교 한의과대학 한방재활의학과교실
²동국대학교

Accredited

ABSTRACT

Objectives This study was performed to evaluate the effects of fermented lotus extracts on prediabetes and hyperlipidemia in high fructose diet rats. Methods Extracts of lotus leaf and lotus root were fermented using 4 different probiotics separately, including Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium breve , and Bifidobacterium longum . Expressions of adipogenic transcription factors including Adiponectin, GLUT-4, Leptin, PPAR gamma, Resistin and Visfatin were analyzed by Real time PCR and Western blotting analysis. Results Fermented lotus extracts reduced blood glucose. Fermented lotus extracts inhibited adipogenic transcription factors by inhibiting preadipocytes differentiation. The level of gene expression of Adiponectin, GLUT-4, Leptin, PPAR gamma, Resistin and Visfatin in relation to that of GAPDH were increase or decrease significantly with the Fermented lotus formulation group. Conclusions Fermented lotus extracts showed hypoglycemic and hypolipidemic effects by inhibiting preadipocyte differentiation and controlling insulin sensitivity in high fructose diet rats.

KEYWORDS

Lotus, Probiotics, Fermentation, Insulin resistance, Hyperlipidemia

Citation status

* References for papers published after 2023 are currently being built.

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Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6