Effects of Bangkeehwangkee-tang (fángjǐhuángqí-tāng) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats (방기황기탕이 Monosodium Iodoacetate로 유발된 흰쥐의 골관절염에 미치는 영향)

김대훈; 강성인; 송민영; choi jin bong (최진봉); 배길준; 한정석; Mi-Sung Yang (양미성); Yong-jeen Shin (신용진)

Effects of Bangkeehwangkee-tang (fángjǐhuángqí-tāng) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats

Journal of Korean Medicine Rehabilitation
Abbr : JKMR
2014, 24(2), pp.15-29
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

김대훈 ¹, 강성인 ², 송민영 ¹, choi jin bong ³, 배길준 ⁴, 한정석 ¹, Mi-Sung Yang ⁵, Yong-jeen Shin ⁶

¹동신대학교 한의과대학 한방재활의학교실
²동신병원
³동신대학교
⁴동신대학교 한의과대학 한방재활의학과교실
⁵동신대학교 한의과대학 재활의학과교실
⁶원광대학교

Accredited

ABSTRACT

Objectives We have studied to know effects of Bangkeehwangkee-tang on the monosodium iodoacetate (MIA) induced osteoarthritis in rats. Methods Osteoarthritis was induced by injection of monosodium iodoacetate into knee joint cavity of rats. Rats are devided into 4 groups; Sham, control, Bangkeehwangkee-tang , Shinbaro. Sham group was injected by normal saline into knee joint cavity only. Control group was taken no treatment and Experimental groups were taken extracts of Bangkeehwangkee- tang and Shinbaro by orally once a day for 4 weeks. The content of TNF-α, IL- 1β and IL-6 in synovial fluids were analysed. COX-2 in chondrocytes and blood PGE2 concentration were analysed. Histopathological examination was performed by Safranin-O fast green staining and Mankins score checking. Results The content of TNF-α, IL-1β in experimental groups were decreased compared with control group. COX-2 in chondrocytes and blood PGE2 concentration in experimental groups were decreased compared with control group. Histopathologically, osteoarthritic scores of experimental groups were decreased compared with control group. But the content of IL-6 in synovial fluids was not significantly compared with control group. Conclusions According to these results, it can be suggested that Bangkeehwangkeetang has anti-arthritic effects on the MIA induced osteoarthritis in rats.

KEYWORDS

Bangkeehwangkee-tang, Osteoarthritis, Monosodium iodoacetate

Citation status

* References for papers published after 2023 are currently being built.

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