@article{ART001897294},
author={정해창 and Jeong， Su-hyeon and Seo,Il-bok},
title={Protective Effects of Banggi-eum (FangchiYin) on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2014},
volume={24},
number={3},
pages={39-50}
TY - JOUR
AU - 정해창
AU - Jeong， Su-hyeon
AU - Seo,Il-bok
TI - Protective Effects of Banggi-eum (FangchiYin) on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2014
VL - 24
IS - 3
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 39
EP - 50
SN - 1229-1854
AB - Objectives The objective of this study is to investigate the protective effects of Banggi-eum (FangchiYin) on the articular cartilage injuries in rat model of osteoarthritis.
Methods Articular cartilage injury was induced by injection of monosodium iodoacetate (MIA) (0.25 mg) into both knee joint cavities of rats. Rats were divided into control group (n=8) and Banggi-eum (FangchiYin) group (n=8), which was taken extracts of Banggi-eum (FangchiYin) by orally for 20 days. At the end of the experiment (20 days after MIA injection), gross and histopathological examinations on the articular structures of knee joints were performed. Proteoglycan (PG) content in articular cartilages was analyzed by safranin O staining method. And also, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) contents in synovial fluid were measured by ELISA method.
Results 1. Grossly, the degree of articular cartilage injury in the Banggi-eum (FangchiYin) group was alleviated compared with the control group. 2. PG content in articular cartilage of the Banggi-eum (FangchiYin) group was increased significantly compared with the control group. 3. Histopathologically, osteoarthritic score of the Banggi-eum (FangchiYin) group was decreased significantly compared with the control group. 4. TNF-α and IL-1β content in synovial fluid of the Banggi-eum (FangchiYin) group was increased compared with the control group. But there was no significance.
Conclusions On the basis of these results, we suggest that Banggi-eum (FangchiYin) have inhibiting effects on the progression of articular cartilage injury in MIA-induced osteoarthritis model.
KW - Banggi-eum (FangchiYin);Monosodium iodoacetate;Articular cartilage in-jury;Proteoglycan
DO -
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ER -
정해창, Jeong， Su-hyeon and Seo,Il-bok. (2014). Protective Effects of Banggi-eum (FangchiYin) on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats. Journal of Korean Medicine Rehabilitation, 24(3), 39-50.
정해창, Jeong， Su-hyeon and Seo,Il-bok. 2014, "Protective Effects of Banggi-eum (FangchiYin) on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats", Journal of Korean Medicine Rehabilitation, vol.24, no.3 pp.39-50.
정해창, Jeong， Su-hyeon, Seo,Il-bok "Protective Effects of Banggi-eum (FangchiYin) on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats" Journal of Korean Medicine Rehabilitation 24.3 pp.39-50 (2014) : 39.
정해창, Jeong， Su-hyeon, Seo,Il-bok. Protective Effects of Banggi-eum (FangchiYin) on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats. 2014; 24(3), 39-50.
정해창, Jeong， Su-hyeon and Seo,Il-bok. "Protective Effects of Banggi-eum (FangchiYin) on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats" Journal of Korean Medicine Rehabilitation 24, no.3 (2014) : 39-50.
정해창; Jeong， Su-hyeon; Seo,Il-bok. Protective Effects of Banggi-eum (FangchiYin) on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats. Journal of Korean Medicine Rehabilitation, 24(3), 39-50.
정해창; Jeong， Su-hyeon; Seo,Il-bok. Protective Effects of Banggi-eum (FangchiYin) on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats. Journal of Korean Medicine Rehabilitation. 2014; 24(3) 39-50.
정해창, Jeong， Su-hyeon, Seo,Il-bok. Protective Effects of Banggi-eum (FangchiYin) on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats. 2014; 24(3), 39-50.
정해창, Jeong， Su-hyeon and Seo,Il-bok. "Protective Effects of Banggi-eum (FangchiYin) on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats" Journal of Korean Medicine Rehabilitation 24, no.3 (2014) : 39-50.
