Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6
-
pISSN : 1229-1854
- https://journal.kci.go.kr/jkmr
KJCKorea
Journal Central
Experimental Study of Lonicerae Caulis and Bee-venom Acupuncture on the Rheumatic Pathologic Model Induced by Adjuvant in Rats
- Journal of Korean Medicine Rehabilitation
- Abbr : JKMR
- 2015, 25(1), pp.17-26
- Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
- Research Area : Medicine and Pharmacy > Korean Medicine
Young Dal Kwon 1, 배명현 1, Seung-ryong Yeom 1, 김진희 1
1원광대학교 한의과대학 한방재활의학과교실
Accredited
ABSTRACT
ObjectivesThis study was carried out to investigate the experimental effects of Lonicerae Caulis and Bee-venom Acupuncture in Yanglingquan (陽陵泉, GB34) that have clinical efficacy in the Rheumatoid Arthritis.
MethodsMaterials of present study are Lonicerae Caulis Extracts (LCE), Bee-Venom Acupuncture (BVP), Sprague-dawley rats (250 g or so, ♂), and various kinds of needing experimental studies. We measured several experimental items of the rats with the arthritis induced by Freund's complete adjuvant (0.2 ml/kg), such as body weight, rate of paw edema, analgesic effect by hot plate method, WBC, TNF-α cytokine and IL-10 cytokine. Rats were divided into four groups; Normal group that was treated with normal saline 1.0 ml (o.p) and 15 μl/kg (GB34) to normal rats, Control group that was treated with normal saline 1.0 ml (o.p) and 15 μl/kg (GB34) to pathologic model rats induced by Freund's complete adjuvant 0.2 ml/kg, Experimental group A that was treated with LCE 1.0 ml (o.p) and normal saline 15 μl/kg (GB34) to pathologic model rats induced by Freund's complete adjuvant 0.2 ml/kg and Experimental group B that was treated with LCE 1.0 ml (o.p) and BVP 15 μl/kg (GB34) to pathologic model rats induced by Freund's complete adjuvant 0.2 ml/kg, and the experiment took over after 28 days. The results were analysed using SPSS for windows 12.0.
ResultsExperimental group A showed the increase in body weight, paw licking times and IL-10 cytokine compared to Control group. Also it was decreased in rate of paw edema, WBC, and TNF-α cytokine compared with Control group. Experimental group B showed the increase in body weight, paw licking times, and IL-10 cytokine compared to Control group, and showed the decrease in rate of paw edema, WBC and TNF-α cytokine compared to Control group. Especially TNF-α cytokine and rate of paw edema were accepted statistical significance compared with Control group.
ConclusionsIt is suggested that Lonicerae Caulis (o.p) and Bee-venom Acupuncture (GB34) can be used in the treatment of rheumatoid arthritis. (J Korean Med Rehab 2015;25(1):17-26)
Statistics
-
254 Viewed
-
1 Downloaded
Tools
Issue List
Citation status
* References for papers published after 2023 are currently being built.
[book]
Peter Parham
/ 2011
/ The Immune System
/ 라이프사이언스
: 399~
[book]
한방재활의학과학회
/ 2008
/ 한방재활의학
/ 군자출판사
: 83~
[book]
William N. Kelly
/ 1985
/ Textbook of rheumatology
/ Saunders company
: 884~
[book]
한의과대학 본초학 출판위원회
/ 2007
/ 본초학
/ 도서출판 영림사
: 265~266
[book]
대한약침학회 학술위원회
/ 2008
/ 약침학
/ ELSEVIER KOREA L.L.C
: 167~
[book]
전국한의과대학 침구경혈학교수
/ 1991
/ 침구학(상)
/ 집문당
: 648~649
[journal]
김무진
/ 2005
/
A Acupuncture Therapy Literature Study on the Knee Rheumatoid Arthritis
/ 대한침구의학회지
/ 대한침구의학회
22(1)
: 191~202
[book]
전국한의과대학 본초학교수
/ 2012
/ 本草學
/ 영림사
: 265~266
[book]
전국한의과대학 침구·경혈학교수
/ 1991
/ 침구학(상)
/ 집문당
[book]
韓國藥學大學協議會 藥物學分科會
/ 1993
/ 藥物學 毒性學實驗
/ 신일상사
: 135~
[book]
金井泉
/ 1984
/ 臨床檢査法提要
/ 高文社
: 217~231
[journal]
Stepaniak JA
/ 1995
/ A comparative study of experimental autoimmune encephalomyelitis in Lewis and DA rats
/ J. Immunol
: 2762~2769
[journal]
Rivera DL
/ 1998
/ Interleukin-10 attenuates experimental fetal growth restriction and demise
/ FASEB J
12(2)
: 189~197
[journal]
Okura, Y
/ 1998
/ Recombinant murine interleukin-12 facilitates induction of cardiac myosin-specific type 1 helper T cells in rats
/ Circ Res
82(10)
: 1035~1042
[journal]
Lobell A
/ 1998
/ Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis
/ J. Exp. Med
187(9)
: 1543~1548
[book]
대한내과학회 해리슨내과학 편집위원회
/ 2006
/ HARRISON'S 내과학
/ 도서출판 MIP
: 2148~
[report]
문형표
/ 2014
/ 2013 국민건강통계 국민건강영양조사 제6기 1차년도(2013)
/ 보건복지부 건강정책과
: 703~
[book]
의학교육연수원
/ 1998
/ 가정의학
/ 서울대학교출판부
: 837~
[journal]
유대현
/ 2010
/
Recent Trend in the Treatment of Rheumatoid Arthritis
/ 대한정형외과학회지
/ 대한정형외과학회
45(6)
: 419~425
[journal]
김영태
/ 2002
/
The direction of the study regarding the treatment of Rheumatoid Arthritis
/ 대한침구의학회지
/ 대한침구의학회
19(5)
: 189~198
[journal]
박진상
/ 2004
/ 생체외 류마토이드 관절염 실험 모델에서 청열사습탕의 효과
/ 한방재활의학과학회지
14(2)
: 29~
[journal]
설재욱
/ 2005
/ 마황강활탕이 Adjuvant관절염에미치는 실험적 효과
/ 한방재활의학과학회지
15(2)
: 55~
[journal]
손동우
/ 2005
/ 趁痛散이 흰쥐의 Adjuvant유발 관절염 및 척수내 C-fos발현에 미치는 영향
/ 한방재활의학과학회지
15(3)
: 2~
[book]
Van Eden W
/ 2001
/ Adjuvant Arthritis in the Rat
/ Current Protocols in Immunology
[journal]
이영철
/ 2005
/
The experimental Studies on the immunomodulational effects of Lonicerae Caulis et Folium.
/ 대한본초학회지
/ 대한본초학회
20(4)
: 141~149
[journal]
하태광
/ 2011
/
Immunomodulatory effects of chlorogenic acid and ethyl acetate fraction from Lonicera japonica on cytokine gene expression profiles in spleen and thymus
/ 대한본초학회지
/ 대한본초학회
26(2)
: 1~10
[journal]
유윤조
/ 2001
/
Effects of Lonicera japonica Water Extracts on the
Blood Pressure in Spontaneously Hypertensive Rats
/ 동의생리병리학회지
/ 한의병리학회
15(6)
: 993~997
[journal]
서병관
/ 2011
/
Antinociceptive Effect and the Mechanism of Bee Venom Pharmacopuncture on Inflammatory Pain in the Rat Model of Collagen-induced Arthritis: Mediation by 5HT-3 & Muscarinic Cholinergic Receptors
/ 대한침구의학회지
/ 대한침구의학회
28(1)
: 37~44
[journal]
정인태
/ 2005
/
The Analgesic Effect and its Mechanism
of Bee Venom Acupuncture in the Collagen-induced Arthritis Rats
/ 대한침구의학회지
/ 대한침구의학회
22(1)
: 99~108
[journal]
박원
/ 2010
/
Neuroprotective and Anti-inflammatory Effects of Bee Venom Acupuncture on MPTP-induced Mouse
/ 대한침구의학회지
/ 대한침구의학회
27(3)
: 105~116
[journal]
박찬열
/ 2000
/ 봉독약침의 항암효과에대한 분자생물학적 연구
/ 대한약침학회지
3(1)
: 1~19
[journal]
양창열
/ 2010
/
Bee Venom Inhibits Prostate Cancer Growth in LNCaP Xenografts via Apoptosis
/ Journal of Pharmacopuncture
/ 대한약침학회
13(1)
: 15~35
[journal]
이상훈
/ 2003
/
Randomized Controlled Double Blind Study of Bee Venom Therapy on Rheumatoid Arthritis
/ 대한침구의학회지
/ 대한침구의학회
20(6)
: 9~
[journal]
이상훈
/ 2003
/
Effects of Bee Venom on the pain, edema, and acute inflammatory reactant of Rheumatoid Arthritis patients
/ 대한침구의학회지
/ 대한침구의학회
20(2)
: 7~84
[thesis]
심소라
/ 2011
/ 파킨슨병에 대한 봉독약침과 침의 임상효과 비교 연구
/ 석사
/ 경희대학교 대학원
[book]
전국한의과대학
/ 2009
/ 대학경락경혈학 각론(하)
/ 의방출판사
: 1024~
[journal]
이동진
/ 2003
/
Clinical Responses of Ultrasound on Adjuvant-Induced Arthritis in Rats
/ 한국전문물리치료학회지
/ 한국전문물리치료학회
10(2)
: 45~59
[book]
강신성
/ 2000
/ 생물 과학
/ 아카데미서적
: 428~
[book]
대한병리학회
/ 1998
/ 병리학
/ 고문사
: 71~103
[journal]
Lewis EJ
/ 1998
/ A simple inflammation model that distinguishes between the action of anti-inflammatory and anti-rheumatic drugs
/ Inflamm Res
47(1)
: 26~35
[journal]
Ulett GA
/ 1998
/ Traditional and evidence-based acupuncture : history, mechanisms, and present status
/ South Med J
91(12)
: 1115~1120
[journal]
Dionne S
/ 1997
/ Quantitative PCR analysis of TNF-alpha and IL-1 beta mRNA levels in pediatric IBD mucosal biopsies
/ Dig Dis Sci
42
: 1557~1566
[journal]
Husby G
/ 1988
/ Synovial localization of tumor necrosis factor in patients with rheumatoid arthritis
/ J Autoimmun
1
: 363~371
[journal]
Chu CQ
/ 1991
/ Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis
/ Arthritis Rheum
34
: 1125~1132
[journal]
Bertolini DR
/ 1986
/ Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors
/ Nature
319
: 516~518
[journal]
Saklatvala J
/ 1986
/ Tumour necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage
/ Nature
322
: 547~549
[journal]
Lipsky PE
/ 2000
/ Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
/ N Eng J Med
343
: 1594~1602
[book]
대한진단검사의학회
/ 2009
/ 진단검사의학
/ 이퍼블릭
: 628~629
[journal]
Lubberts E
/ 2000
/ Intraarticular IL-10 gene transfer regulates the expression of collagen-induced arthritis(CIA)in the knee and ipsilateral paw
/ Clin Exp Immunol
120
: 375~383
[journal]
Lubberts E
/ 1998
/ Regulatory role of interleukin 10 in joint inflammation and cartilage destruction in murine streptococcal cell wall (SCW) arthritis. More therapeutic benefit with IL-4/IL-10 combination therapy than with IL-10 treatment alone
/ Cytokine
10
: 361~369