2015, Vol.25, No.1

Experimental Study on the Cannabis Fructus on Exercise Capacity and Cognitive Function in Vascular Dementia Rat Model

배길준 , 송민영 , choi jin bong and 1 other persons | 2015, 25(1) | pp.1~15 | number of Cited : 6

ObjectivesThe aim of this study was to investigate the effects of Cannabis Fructus on exercise capacity and cognitive function in chronic hypoperfusion induced vascular de-mentia rat model.MethodsVascular dementia rat models were induced by chronic cerebral hypoperfusion through bilateral common carotid arteries occlusion (BCCAO). All rats were randomly div-ided into 4 groups: normal group; control group; CF I group (feeding Cannabis Fructus 100 mg/kg); CF II group (feeding Cannabis Fructus 300 mg/kg). In order to study the effects of oral administration of Cannabis Fructus on vascular dementia rat models, corner turn test, hole board test, radial arm maze test, passive avoidance test were taken and Acetylcholine (ACh) activity, Acetylcholinesterase (AChE) activity, serum of Vascular endothelial growth factor (VEGF) protein level were measured. Also histological findings of the liver, kidney, brain and the change of Tau immunoreactive neurons in hippocampus were observed.ResultsCF I and CF II showed significant improvement in corner turn test, hole board test, radial arm maze test, passive avoidance test, Acetylcholine (ACh) activity, Acetylcholine-sterase (AChE) activity, the serum of Vascular endothelial growth factor (VEGF) protein level and the change of Tau immunoreactive neurons in hippocampus. CF I showed more sig-nificant effect than CF II in these tests. However in histological observations of the liver and kidney both CF I and CF II showed glomerular injury and hepatotoxicity.ConclusionsThese results suggest that Cannabis Fructus was helpful in improving ex-ercise capacity and cognitive function on Chronic hypoperfusion induced Vascular Dementia rats. However Cannabis Fructus affects the liver and kidney, therefore suggest that this is an area for further study. (J Korean Med Rehab 2015;25(1):1-15)

Experimental Study of Lonicerae Caulis and Bee-venom Acupuncture on the Rheumatic Pathologic Model Induced by Adjuvant in Rats

Young Dal Kwon , 배명현 , Seung-ryong Yeom and 1 other persons | 2015, 25(1) | pp.17~26 | number of Cited : 0

ObjectivesThis study was carried out to investigate the experimental effects of Lonicerae Caulis and Bee-venom Acupuncture in Yanglingquan (陽陵泉, GB34) that have clinical efficacy in the Rheumatoid Arthritis. MethodsMaterials of present study are Lonicerae Caulis Extracts (LCE), Bee-Venom Acupuncture (BVP), Sprague-dawley rats (250 g or so, ♂), and various kinds of needing experimental studies. We measured several experimental items of the rats with the arthritis induced by Freund's complete adjuvant (0.2 ml/kg), such as body weight, rate of paw edema, analgesic effect by hot plate method, WBC, TNF-α cytokine and IL-10 cytokine. Rats were divided into four groups; Normal group that was treated with normal saline 1.0 ml (o.p) and 15 μl/kg (GB34) to normal rats, Control group that was treated with normal saline 1.0 ml (o.p) and 15 μl/kg (GB34) to pathologic model rats induced by Freund's complete adjuvant 0.2 ml/kg, Experimental group A that was treated with LCE 1.0 ml (o.p) and normal saline 15 μl/kg (GB34) to pathologic model rats induced by Freund's complete adjuvant 0.2 ml/kg and Experimental group B that was treated with LCE 1.0 ml (o.p) and BVP 15 μl/kg (GB34) to pathologic model rats induced by Freund's complete adjuvant 0.2 ml/kg, and the experiment took over after 28 days. The results were analysed using SPSS for windows 12.0. ResultsExperimental group A showed the increase in body weight, paw licking times and IL-10 cytokine compared to Control group. Also it was decreased in rate of paw edema, WBC, and TNF-α cytokine compared with Control group. Experimental group B showed the increase in body weight, paw licking times, and IL-10 cytokine compared to Control group, and showed the decrease in rate of paw edema, WBC and TNF-α cytokine compared to Control group. Especially TNF-α cytokine and rate of paw edema were accepted statistical significance compared with Control group. ConclusionsIt is suggested that Lonicerae Caulis (o.p) and Bee-venom Acupuncture (GB34) can be used in the treatment of rheumatoid arthritis. (J Korean Med Rehab 2015;25(1):17-26)

Anti-nociceptive and Anti-inflammatory Effects of Gami-cheongyulsaseub-tang in Arthritic Model

SONG YUNG SUN , 김일현 , 이하일 and 2 other persons | 2015, 25(1) | pp.27~44 | number of Cited : 2

ObjectivesThis study was carried out to find the effects of Gami-cheongyulsaseub-tang (hereinafter referred to GCST) on the inhibition of zymosan-induced pain in rats and collagen II-induced arthritis (CIA) in DBA/1J mouse. MethodsAs an acute inflammatory pain model, peripheral inflammation was induced by intraplantar injection of zymosan into the right hind paw in rats and then the hyperalgesia and pain regulating factors in spinal cord were analyzed. As a chronic inflammation model, the mixture of collagen II and complete Freund’s adjuvant was treated into mice to establish rheumatoid arthritis and then body weight, thickness of hind paw, pathological change of spleen, immunological rheumatoid factor (IgG1, IgG2a, IgG2b, IgM and anti-collagen II), pro-inflammatory cytokines, and bone injury were analyzed. ResultsIn the acute inflammatory pain model, GCST significantly inhibited the thermal and mechanical hyperalgesia and the pain regulating factors, including Fos, CD11b, PKA and PKC, in the spinal cord with a dose-dependent manner. In the chronic rheumatoid arthritis model, GCST administration decreased arthritic index and paw edema as compared with CIA control group. In particular, GCST reduced significantly the serum levels of total IgG2a, IgG2b, IgM, and specific anti-collagen II, but not total IgG1. GCST also resulted in the attenuation of bone injury and spleen enlargement/adhesion in CIA mice. Moreover, the secretion of pro-inflammatory cytokines TNF-α and IL-1β in CIA mice was significantly reduced by GCST in a dose-dependent manner. ConclusionsComparison of the results in this study showed that GCST had anti-nociceptive and immunomodulatory effects. These data imply that GCST can be used as an effective drug for not only rheumatoid arthritic pain but also other auto-immune diseases. (J Korean Med Rehab 2015;25(1):27-44)

The Effects of High Temperature High Pressure Steam Sterilization on Woohwangchungsimwon

조창영 , Lee In Hee , 이재웅 and 3 other persons | 2015, 25(1) | pp.45~52 | number of Cited : 4

ObjectivesTo check marker content for appropriate quality control of Woohwangchungsimwon sterilized to ensure microbiological safety and to observe antioxidant activity for any changes in efficacy. MethodsTo measure any effects of sterilization on the effective compounds, 8 ingredients of Woohwangchungsimwon were screened for any changes in marker content using HPLC-DAD. Using the colorimetric method on the microplate reader any changes in total phenolic compound and flavonoid levels were observed. Antioxidant activity was measured using the DPPH, ABTS, and FRAP. ResultsOf the ingredients of Woohwangchungsimwon, 8 were subject to quantitative analysis before and after sterilization. 21.6 mg and 1.93 mg of Glycyrrhizin was found in Glycyrrhiza uralensis Fischer pre and post sterilization, respectively. Decursin found in Angelica gigas Nakai increased from 0.16 mg to 0.29 mg after sterilization. Bilirubin found in Gallstone of Bostaurusvar. domesticus increased from 0.24 mg to 0.33 mg. Cinnamic acid found in Cinnamomum cassia Blume increased from 0.02 mg to 0.05 mg. Ginsenoside Rb1 found in Panax ginseng C. A. Meyer decreased from 0.02 mg to 0.14 mg. Paeoniflorin found in Paeonia lactiflora Pallas increased from 1.05 mg to 1.13 mg. Amygdalin found in Armeniacae Amarum Semen increased from 2.68 mg to 2.83 mg. L-muscone found in Musk increased from 0.63 mg to 0.76 mg. As for total phenolic compound and total flavonoid content, there was a 1.22 and 4.15-fold increase. DPPH and ABTS increased by 20.45% and 20.69%, respectively. FRAP activity was 2.78 times more active post stabilization. ConclusionsThis study confirmed that high temperature high pressure steam sterilization, a method used to ensure microbiological safety of Woohwangchungsimwon, does not affect marker content; in other words, does not affect quality of the Woohwangchungsimwon. It could also be seen that total phenolic compound and flavonoid content increased after sterilization. An antioxidant activity test showed that there was significantly increased activity of antioxidants. (J Korean Med Rehab 2015;25(1):45-52)

Comparative Analysis of Common Herbs for Pain Related Disease between Yak-Jing and Textbook of Herbology

차윤엽 , 정준교 , 박원형 | 2015, 25(1) | pp.53~61 | number of Cited : 3

ObjectivesThe purpose of this study is to compare the common herbs for pain related disease between Yak-Jing and textbook of herbology. MethodsWe searched the formation of “Koho” and theory of Todo yoshimasu. We selected the common herbs that is used for pain related disease in Yak-Jing and textbook of herbology. These herbs were compared with each other. Result1. Common Herbs for pain related disease are Ephedrae Herba (麻黃), Aconiti Lateralis Preparata Radix (附子), Euphorbiae Kansui Radix (甘遂), Euphorbiae pekinensis Radix (大戟) Daphnis Genkwa Flos (芫花), Atractylodis Rhizoma (朮), Paeonia Radix Rubra (芍藥), JujubaeFructus (大棗), Gypsum (石膏), Anemarrhenae Rhizoma (知母), Cinnamomi Ramulus (桂枝), Poria (茯苓), Rhei Rhizoma (大黃), Natrii Sulfas (芒草), Pueraiae Radix (葛根). There are some difference between textbook of herbology and Yak-Jing about Aconiti Lateralis Preparata Radix (附子), Paeonia Radix Rubra (芍藥), Atractylodis Rhizoma (蒼朮), Pueraiae Radix (葛根). 2. Preparata Radix (附子) excrete water poisons (水毒) in Yak-Jing, but it has the effect of restore yang and tonify fire (回陽補火) in textbook of herbology. 3. Paeonia Radix Rubra (芍藥) is effective for pathological condition caused by the formation of the band and spasm (結實拘攣) in Yak-Jing, but it is to cure heat pattern in textbook of herbology. 4. Atractylodis Rhizoma (蒼朮) has the effect of water-draining (利水) in Yak-Jing, but it has the effect of dispersing (發散) in textbook of herbology. 5. Pueraiae Radix (葛根) is used in dyspnea and sweating (喘而汗出) in Yak-Jing, but it is to cure engender fluid (生津), skin disease, diarrhea in textbook of herbology. ConclusionThere are some difference between textbook of herbology and Yak-Jing in the herb medicine that is used in pain related disease. (J Korean Med Rehab 2015; 25(1):53-61)

The Analysis of Research Trends on Forest Therapy in the Korean Journal

Han Chang Hyun , 성수현 , Jong-Hyun Park and 1 other persons | 2015, 25(1) | pp.63~70 | number of Cited : 3

Review on the Study of Ankle Sprain Published in Korea

이충희 , 김빛나라 , 정 훈 and 3 other persons | 2015, 25(1) | pp.71~76 | number of Cited : 4

Clinical Study on Pain Index, Radiological Evaluation and MMPI of Traffic Accident Patient

김성태 , 송민영 , 김대훈 and 6 other persons | 2015, 25(1) | pp.77~85 | number of Cited : 5

Effect of Dangguisoo-san plus Yuhyangjeongtong-san (Dangguixu-san plus Ruxiangdingtong-san) in the Traffic Accidents Patients with Night Pain

Suhyeon Jeong , 박정우 | 2015, 25(1) | pp.87~93 | number of Cited : 3

A Case Report on Patient with Guillain-Barre Syndrome Improved by Korean Medical Combined Treatment

Kwang-ho Heo , Heo, In , Hwang Eui-hyoung and 2 other persons | 2015, 25(1) | pp.95~101 | number of Cited : 8

A Case Report on a Patient of Achilles Tendinitis Treated with Gyeon-mak Chuna, Korean Medicine and Graston Technique

박재홍 , 오은영 , 이흔주 and 2 other persons | 2015, 25(1) | pp.103~110 | number of Cited : 5

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Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6

2015, Vol.25, No.1