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Osteoarthritis Model Induced by Monosodium Iodoacetate: Good Model for Long-term Drug Efficacy Test

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2015, 25(4), pp.21-28
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

서일복 1 박동수 1

1세명대학교

Accredited

ABSTRACT

ObjectivesThis study was aimed to offer basic data in long term drug efficacy test using monosodium iodoacetate-induced osteoarthrits model.MethodsSixty male rats were divided into normal and osteoarthritic group. Rats of nor-mal group were injected with 0.1 ml physiological saline, and rats of osteoarthritic group were inected with 0.1 ml monosodium iodoacetate (3 mg/ml) into each left and right knee joint cavities. Gross examination, proteoglycan contents and histopathological examination on the knee joint were performed at 10, 20, 40, and 60 days after injection.ResultsGrossly, degenerative changes at 10 days, desquamation at 40 days, and ulcer-ation of articular cartilages at 60 days were observed. Proteoglycan contents in articular cartilages were decreased rapidly to 40 days, after than decreased gradually. Osteoarthritic scores were increased rapidly to 20 days, after than increased gradually to 60 days.ConclusionsFrom above results, osteoarthritis model induced by a single intra-articular injection of monosodium iodoacetete is useful model for long term drug efficacy test. (J Korean Med Rehab 2015;25(4):21-28)

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