2015, Vol.25, No.4

Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6

pISSN : 1229-1854
https://journal.kci.go.kr/jkmr

ObjectivesThis study was intended to clarify the anti-inflammation and anti-oxidation ef-fects of gamikyejakjimo-tang herbal acupuncture (GKHA) for osteoarthritis.MethodsOsteoarthritis was induced by injection of MIA into right knee joint cavities of rats. Rats were divided into a total of 4 groups (n8). The 4 groups were normal group, control group, positive comparison group and expeimental group. Indomethacin and GKHA were medicated for a total of 4 weeks. After that, functions of liver and kidney by AST, ALT, creatinine, BUN, DPPH and ABTS free radical scavenging activity, ROS (reactive oxygen species) production, NO (Total Nitric oxide), IL-1β, IL-6, TNF-α production, weight changes in the hind legs of MIA-induced osteoarthritis rat, serum PGE2, TIMP-1, MMP-2, MMP-9, LTB4, hs-CRP, and white blood cells, neutrophils, lymphocytes, mono-cytes were measured. The volume of cartilage was observed by micro CT arthrography. H&E and Safranin-O staining were used to examine the injury of synovial tissue. Results1. In the hind leg weight bearing measurement, level of weight was increased. 2. AST, ALT, BUN, creatinine were decreased. 3. The production of total white blood cell was decreased, and the production of neutrophils, lymphocytes, monocytes were significantly decreased. 4. The production of NO, PGE2, TIMP-1, MMP-2, MMP-9, LTB4 were sig-nificantly decreased, and the production of hs-CRP was also decreased but with no significance. 5. The cartilage volume was significantly increased. 6. In H&E staining and Safranin-O staning, the cartilage cell appeared to be proliferated, and proteoglycans ap-peared to be increased. ConclusionsBased on the results above, Gamikyejakjimo-tang Herbal Acupuncture has anti-oxidation and anti-inflammation effects, which leads to suppressing the underlying causes and the progression of osteoarthritis. (J Korean Med Rehab 2015;25(4):1-20)

ObjectivesThis study was aimed to offer basic data in long term drug efficacy test using monosodium iodoacetate-induced osteoarthrits model.MethodsSixty male rats were divided into normal and osteoarthritic group. Rats of nor-mal group were injected with 0.1 ml physiological saline, and rats of osteoarthritic group were inected with 0.1 ml monosodium iodoacetate (3 mg/ml) into each left and right knee joint cavities. Gross examination, proteoglycan contents and histopathological examination on the knee joint were performed at 10, 20, 40, and 60 days after injection.ResultsGrossly, degenerative changes at 10 days, desquamation at 40 days, and ulcer-ation of articular cartilages at 60 days were observed. Proteoglycan contents in articular cartilages were decreased rapidly to 40 days, after than decreased gradually. Osteoarthritic scores were increased rapidly to 20 days, after than increased gradually to 60 days.ConclusionsFrom above results, osteoarthritis model induced by a single intra-articular injection of monosodium iodoacetete is useful model for long term drug efficacy test. (J Korean Med Rehab 2015;25(4):21-28)

ObjectivesWe have attempted to provide the basis of treatment effects by considering foreign & domestic randomized controlled trials (RCTs), being implemented with catgut- embedding therapy for lumbar disc herniation.MethodsWe found the literatures prepared in Korean, English, and Chinese by December 2014 in electronic databases (Pubmed, Science Direct, Proquest, OASIS, KMbase, NDSL, RISS, National Assembly Library). We choosed RCTs by selection criteria through abstracts & articles, extracted and analyzed data. Cochrane's Risk of Bias Tool was used & implemented for the risk of bias.ResultsThe total of 17 studies were included in the review. 88.2% of studies were ac-complished within the last decade. The experimental group has shown more significant ef-fects in 70.6% of studies, and the long-term & partial significant results were obtained in 29.4% of studies. Affected lumbar area and pelvic limb area with radiating pain were mostly selected for acupoint.ConclusionsOverall and partial significant results were obtained from 17 foreign & do-mestic comparative RCTs which substantiates the treatment effects of catgut-embedding therapy for lumbar disc herniation. Since all studies, however, were exposed to the risk of bias, so future research of higher quality shall be necessary. (J Korean Med Rehab 2015;25(4):29-40)