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Influence of Galgeun-tang on Gene Expression in Diet-Induced Obese Mice

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2016, 26(2), pp.1-12
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

예성애 1 김호준 2 KO SEONG-GYU 3 SONG YUN KYUNG 1

1가천대학교
2동국대학교
3경희대학교

Accredited

ABSTRACT

ObjectivesThe purpose of this study was to evaluate anti-obesity effect of Galgeun- tang (gegentang) and elucidate the effect of it on gene expression related to obesity.MethodsThe experiments were performed with the use of Diet-Induced Obese mice. They were grouped NC (normal control), HFD (high fat diet control), GGT (Galgeun-tang (gegentang), 700 mg/kg), ORL (Orlistat, 10 mg/kg). GGT was orally administered for 12 weeks. Body weight was measured every week. Real-time PCR was performed to inves-tigate the effect of GGT on gene expression in liver tissue.ResultsGGT group and ORL group were reduced in body weight compared with HFD. HFD increased PPARγ, SREBP-1, Leptin, aP2, FATP1, FAS gene expression compared with NC. GGT increased FATP1 gene expression. But GGT reduced PPARγ & FAS gene expression in liver tissue of diet-induced obese mice compared with HFD. ConclusionsThese results suggest that GGT is supposed to have a certain impact on the treatment of obesity. But more study is needed in the future. (J Korean Med Rehab 2016;26(2):1-12)

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