2016, Vol.26, No.2

Influence of Galgeun-tang on Gene Expression in Diet-Induced Obese Mice

예성애 , 김호준 , KO SEONG-GYU and 1 other persons | 2016, 26(2) | pp.1~12 | number of Cited : 2

Anti-obesity Effects of Galgeun-tang in High Fat Diet Induced Obese Mice Model

기성훈 , 김호준 , KO SEONG-GYU and 1 other persons | 2016, 26(2) | pp.13~28 | number of Cited : 3

ObjectivesTo investigate anti-obesity effects of Galgeun-tang, an herbal formula, in high fat diet induced obese mice model.Methods24 Male C57Bl/6J mice were randomly assigned to normal group fed with nor-mal research diet (NOR, n=6), high fat diet control group treated with water (HFD, n=6), high fat diet group treated with Orlistat (ORL, n=6, Orlistat 10 mg/kg), and high fat diet group treated with Galgeun-tang (GGT, n=6, Galgeun-tang 700 mg/kg). 12 weeks later, body weight, fat weight, liver weight, blood glucose, total cholesterol, triglyceride, HDL, ALT, AST, obesity related neuropeptides and adipokines, ratio of gut microbiota, and histo-pathology of liver were evaluated.ResultsIn the GGT group, 1. body weight gain, liver weight gain, and total fat weight gain were significantly less than those in the HFD group. 2. blood glucose level was significantly lower and insulin level was significantly higher than in the HFD group. 3. total cholesterol level and triglyceride (TG) level were significantly lower and high density lipoprotein (HDL) level was significantly higher than in the HFD group. 4. appetite-promoting ARC neuro-peptides such as Agrp and Npy were significantly less and appetite-inhibiting ARC neuro-peptide, Cart was significantly more than in the HFD group in qRT-PCR analysis. 5. adipo-nectin level and visfatin level were significantly higher, and resistin level and leptin level was sig-nificantly lower than in the HFD group. 6. the relative level of Bacteroidetes was significantly higher, and the relative level of Firmicutes was significantly lower than in the HFD group. 7. the increase of adipose tissue was significantly more inhibited than in the HFD group.ConclusionsThe present study showed that Glageun-tang exerts anti-obesity effects in that it. 1. inhibited the increase in body weight, liver weight, and total fat weight. 2. de-creased the level of TG, and increased the level of HDL. 3. influenced neuropeptides and adipokines that are important in regulating food intake and changes of body weight. 4. modified the beneficial quantitative changes in gut microbiota suppressing the tendency to-ward obesity. (J Korean Med Rehab 2016;26(2):13-28)

The Effects of Gyejibokryeong-hwan (桂枝茯苓丸) for Wound Healing after Skin Suture

정 훈 , 이은정 , Minseok Oh | 2016, 26(2) | pp.29~50 | number of Cited : 4

ObjectivesThere is few Korean medicinal studies about post-operation wound healing despite much effort for minimizing wound or post-op scar. The aim of this study is to evaluate the wound healing effect of Gyejibokryeong-hwan (Guizhifuling-wan, GBH) after skin suture. Methods＜In vitro＞ We observed anti-oxidative and anti-inflammatory effect by using lipopolysaccharide (LPS)-treated RAW 264.7 cells. For anti-oxidation, we mesured the total amount of polyphenol, flavonoid, DPPH scavenging ability, ABTS scavenging ability and the value of ROS production, and for anti-inflammation, we mesured the amount of NO and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6). ＜In vivo＞ Thirty SD rats were divided into five equal groups (n=6, one normal, two controls and two experimentals). All groups except normal group were made a scar (around 1x4 cm2) in the back by the depth of the fascia and then sutured by a thread and needle. Normal group rats received no treatment at all. Control group rats were fed distilled water, and positive control group rats were per-cutaneously applied terramycin once in 2 days. GBH 200 group rats were orally medicated GBH 200 mg/kg, and GBH 400 group rats were orally medicated GBH 400 mg/kg per day for two weeks. We analyzed the blood samples (WBC, neutrophil, lymphocyte, monocyte, eosinophil), and the serums (TIMP-1, MMP-2, MMP-2. PGE2, TGF-β, VEGF), and exam-ined the wounded skin tissue histopathologically.Results＜in vitro＞ 1. DPPH and ABTS scavenging activity was increased concen-tration-dependantly, and ROS production was significantly increased in GBH treated cells (100 μg/ml). Therefore in this study, Gyejibokryeong-hwan appears to have the an-ti-oxidative. 2. NO production was significantly reduced in GBH treated cells (100 μg/ml), and IL-1β production was significantly reduced in GBH treated cells (1 μg/ml). But, TNF-α and IL-6 did not show uneffective action. Therefore in this study, Gyejibokryeong-hwan did not show any significant effect on anti-inflammatory process. ＜in vivo＞ 1. Monocyte and neutrophil was significantly increased in GBH (200, 400) groups. WBC, lymphocyte and eosinophil did not show significant change. 2. TIMP-1, MMP-2, VEGF were sig-nificantly increased in GBH 400 group, PGE2 was significantly reduced in GBH 400 group. TGF-β was significantly increased in GBH (200, 400) groups, and MMP-9 was increased concentration-dependantly in GBH groups, but there was no significance. 3. In histopatho-logical examinations, collagen was significantly increased and keratin was significantly de-creased in GBH (200, 400) groups.ConclusionsAccording to in vitro experiment, GBH appears to have the anti-oxidative effect and in vivo experiment, GBH stimulate the wound healing process hematologically and histopathologically. In conclusion, the results suggest that GBH promotes wound heal-ing after skin suture. (J Korean Med Rehab 2016;26(2):29-50)

Study on Long-Term Preservation of Hwangnyunhaedok-Tang Pharmacopuncture

이진호 , 하인혁 , Mi-Riong Kim and 5 other persons | 2016, 26(2) | pp.51~59 | number of Cited : 0

A Review of Recent Studies for Treatment of TMD Using CNKI Database

김정섭 , 김동은 , 정동훈 and 2 other persons | 2016, 26(2) | pp.61~74 | number of Cited : 5

Effects of the Pharmacopuncture in Animal Models for Treatment of Osteoporosis: A Review of Animal Study Reports Published in Korea

김정민 , 최수민 , Hee Duk An | 2016, 26(2) | pp.75~83 | number of Cited : 3

Thermographic Study on Effectiveness of Acupuncture, Electro-Acupuncture and Acupuncture with Pulsed Electromagnetic Therapy on Upper Extremity of Healthy and Hemiplegic Group

이종하 , 송미영 , Dongho Keum | 2016, 26(2) | pp.85~96 | number of Cited : 2

Effect of an Aqueous Extract of Poncirus trifoliate (L.) Raf. in Stroke Patient with Constipation

Moon Hyo Jeong , LEE SU KYUNG , Noh Seeung and 1 other persons | 2016, 26(2) | pp.97~103 | number of Cited : 1

The Study on Correlation between the Degree of Herniated Intervertebral Lumbar Disc at L4∼5 Level and Improvement of Low Back Pain Treated by Korean Medicine Therapy

Hyung-Jin Yoo , 이현호 , 정성현 and 4 other persons | 2016, 26(2) | pp.105~121 | number of Cited : 0

ObjectivesThe purpose of this study was to compare the effects between the degree of herniated intervertebral lumbar disc (HIVD) at L4-5 level and improvement of low back pain treated by Korean Medicine therapy.Methods567 patients who received inpatient treatment from May 2014 to December 2015 in the Daejeon-Jaseng of Korean Medicine Hospital were divided into 6 groups by the degree of HIVD at L4-5 level confirmed with a Lumbar spine magnetic resonance imaging. All patients received a combination of treatment including acupunture, chuna manual ther-apy, pharmacopunture, herbal medication. They were compared and analyzed on the basis of improvement between measuring Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), EuroQol-5 Dimension Index (EQ5D Index) as they were hospitalized and as they were discharged. The statistically significance was evaluated by SPSS 23.0 for windows.ResultsAfter treatment, Normal stage on Intervertebral Lumbar Disc at L4-5 level group’s Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), EuroQol-5 Dimension Index (EQ5D Index) improvement was 1.30±1.62, 4.52±11.82 and 0.04±0.11 respectively. Bulging group’s improvement was 3.25±2.81, 8.28±13.02 and 0.09±0.17 respectively. Spinal canal occupying ratio (SOR) less than 20 group’s improvement was 2.15±1.92,11.79±17.81 and 0.13±0.23 respectively. SOR 20 to less than 40 stage group's improve-ment was 2.13±1.92. 10.79±15.93 and 0.10±0.26 respectively. SOR 40 to less than 60 group’s improvement was 2.16±2.24, 9.80±16.62 and 0.15±0.25 respectively. Surgery group’s improvement was 2.47±2.21, 11.64±18.53 and 0.15±0.27 respectively (p＜0.03). But there was no statistically significance between 6 group’s improvement after treatment (p＞0.05).ConclusionsAfter inpatient treatment by Korean Medicine therapy, Most patient’s pain, disability and Health Related Quality of Life was improved significantly. But there was no statistically correlation between the degree of HIVD at L4-5 level and improvement of low back pain. So We think that future research of higher quality and correct statistics shall be necessary. (J Korean Med Rehab 2016;26(2):105-121)

Pilot Study on Characterization of Patients with Low Back Pain: Multi-center, Prospective, Observation Study

박창현 , Bo-Hyoung Jang , 고유미 and 6 other persons | 2016, 26(2) | pp.123~132 | number of Cited : 3

ObjectivesThe aim of this study done as pilot study is to analyze the current state of pa-tients who have low back pain through registry.MethodsThis study is done under approval of Gil Oriental Medical Hospital of Gachon University, Oriental Medical Hospital of Sangji University, Jecheon Oriental Medical Hospital of Se-Myung University IRB. Among subjects who signed the consent form by their own will, we decided whom to register as subjects of this study by the standard of selection and exception. We collected the sociological investigation, character of low pack pain, degree of symptom which they felt before and after the hospitalization from registered subjects.Results1. The number of the subjects is 16. The average age is 41.0. 9 of them are fe-male, 7 of them are male. Most of the subjects have history illness which has connection with low pack pain. 2. According to the patient's free description of the back pain, 6 of them suffered throbbing pain. And 8 of the patients have chronic pain, 6 of them have inter-mittent pain of back pain analysing the character of the low back pain. They answered the pain lasted for 47.6 minutes on average. 3. About the change on the average R.O.M. of L-spine, R.O.M. of Lateral bending, Extension, Flexion, Rotation has increased after leaving the hospital compared with before hospitalization. 4. The amount of discomfort or strength of pain, which was checked by VAS on the day of leaving the hospital, has decreased than they were before the hospitalization. And there was the improvement on the dysfunction score and EQ-5D.ConclusionsThrough this study, we specifically analyzed the symptoms of the low back pain by accumulating the analysis about the symptoms using several indicators and de-scription which is freely spoken by patients about their symptoms. Further research is ex-pected to complete multi-center registry by building registry and by using it, to get various epidemiologic informations about low back pain. (J Korean Med Rehab 2016;26(2): 123-132)

The Influential Factors Associated with Hospitalization Period of Patients from Traffic Accident by Groups: A Korean Medicine Hospital Experience, Respective Chart Review

Dong Hwi Jeon , 이은정 , Minseok Oh | 2016, 26(2) | pp.133~144 | number of Cited : 4

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Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6

2016, Vol.26, No.2