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Effect of an Aqueous Extract of Poncirus trifoliate (L.) Raf. in Stroke Patient with Constipation

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2016, 26(2), pp.97-103
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

Moon Hyo Jeong 1,  LEE SU KYUNG 1,  Noh Seeung 1,  Min Cheol Joo 1

1원광대학교

Accredited

ABSTRACT

ObjectivesTo evaluate the effects and safety of the aqueous extract of the dried, im-mature fruit of Poncirus trifoliate (L.) Raf. (Rutaceae) (PF) in stroke patients with constipation.MethodsA total of 22 patients were recruited. Patients were interviewed about the clin-ical informations, constipation score and Bristol stool form scale at twice, before intake PF and after intake PF 2 weeks. The total and segmental colon transit time (CTT) were meas-ured by using radio-opaque markers (KolomarkⓇ). The degree of stool retention was eval-uated by the plain abdominal radiography and was scored by Leech score. ResultsBefore intake PF, constipation scores ranged from 3 to 12, average 6.54±2.87and Bristol stool form scale ranged from 1 to 6, average 3.86±1.21. CTTs were 9.05±6.89 hours, 14.29±10.68 hours, 12.11±7.19 hours and 35.40±19.5 hours in the right, left, rectosigmoid and total colon, respectively. Stool retention score was 2.45±0.61,2.3±0.86, 1.9±0.85, 6.65±1.56 in the right, left, rectosigmoid and total colon, respec-tively. After 2 weeks, constipation scores ranged from 2 to 8, average 4.28±2.05 and Bristol stool form scale ranged from 1 to 6, average 4.17±1.04. CTTs were 7.41±8.86hours, 11.12±9.12 hours, 8.83±8.75 hours and 27.3±20.2 hours in the right, left, rec-tosigmoid and total colon, respectively. Stool retention score was 1.9±0.64, 2.2±0.69,1.4±0.88, 5.5±1.39 in the right, left, rectosigmoid and total colon, respectively. There were statistically significant difference in the total and rectosigmoid colon CTT and constipation score, Stool retention score in right and rectosigmoid colon (p＜0.05) after PF therapy. ConclusionsThese results suggest potential for PF therapy in stroke patient with constipation. (J Korean Med Rehab 2016;26(2):97-103)

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