Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6
-
pISSN : 1229-1854
- https://journal.kci.go.kr/jkmr
KJCKorea
Journal Central
Anti-Oxidative and Anti-Inflammatory Effects of Cheongajihwang-Tang Extract on RAW264.7 Cells
- Journal of Korean Medicine Rehabilitation
- Abbr : JKMR
- 2016, 26(3), pp.51-58
- Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
- Research Area : Medicine and Pharmacy > Korean Medicine
1세명대학교 한의과대학 한방재활의학과교실
Accredited
ABSTRACT
ObjectivesThis study was designed to investigate whether the Cheongajihwang-Tang (CT) has an inhibitory effect association with oxidation or inflammation in RAW264.7 cells.MethodsCytotoxic activity of CT extract on RAW264.7 cells was evaluated by using 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) solution. Nitric oxide production was measured using Griess reagent system. The total phenolic contents and 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity was measured to evaluate the anti-oxidative effects of CT. Dichlorofluorescin diacetate (DCFH-DA) has been used as a substrate for measuring intracellular oxidant production.ResultsCheongajihwang-Tang does not impair the cell viability in tested concentration. CT showed anti-oxidative effects in vitro by decreasing electron donating ability, and also showed anti-inflammatory effects suppressing NO and ROS expression in LPS induced RAW264.7 activation. CT inhibited the generation of intracellular ROS production as dose dependant manner.ConclusionsCT has anti-oxidative effects and anti-inflammatory activities. These results indicate that CT extract has an anti-inflammatory activities via anti-oxidative effects. (J Korean Med Rehabil 2016;26(3):51-58)
Statistics
-
236 Viewed
-
1 Downloaded
Tools
Issue List
Citation status
* References for papers published after 2023 are currently being built.
[journal]
배기춘
/ 2012
/
The anti-inflammatory effects of ethanol extract of Allium Hookeri cultivated in South Korea
/ 대한본초학회지
/ 대한본초학회
27(6)
: 55~61
[journal]
Greig FH
/ 2012
/ Physiological effects of oxidized phospholipids and their cellular signaling mechanisms in inflammation
/ Free Radic Biol Med
52(2)
: 266~280
[journal]
Lee DU
/ 1991
/ Oxidative stress and age-related changes in microsomal mixed function oxidase activity
/ Kor.J.Gerontol
1(2)
: 187~201
[journal]
Volicer L
/ 1990
/ Involvement of free radicals in dementia of the Alzheimer’s type, a hypothesis
/ Neurobiol Aging
11
: 567~571
[journal]
Kim HJ
/ 2007
/ Anti-oxidative activities of phenolic compound isolated from Inonotus obliquus
/ Kor.J.Pharmacognogy
38
: 1~16
[journal]
Finkel T
/ 2000
/ Oxidants, oxidative stress and the biology of aging
/ Nature
408(6809)
: 239~247
[journal]
Chung HY
/ 2001
/ The inflammation hypothesis of aging : Molecular modulation by calorie restriction.
/ Ann.N.Y Acad Sc
928
: 327~335
[journal]
김현정
/ 2006
/
부위별 새송이버섯 추출물의 항산화 및 항균효과
/ 한국식품과학회지
/ 한국식품과학회
38(6)
: 799~804
[book]
Kim YH
/ 2001
/ Cheonggangeuigam
/ Seongbosa
: 304~
[book]
Jin SM
/ 1985
/ Taepyeonghyeminhwajegukbang
/ Ren min wei sheng Publishing INC
: 175~
[book]
Qian Yi
/ 2002
/ Soayakjeungjikgyeol
/ Yeogang Publishing INC
: 11~
[journal]
Kim SH
/ 2002
/ Peroxynitrite scavenging activity and its mechanism of Cheonga-hwan
/ Kor.J.oriental medicine
23(4)
: 55~63
[journal]
문성식
/ 2003
/
Study on antioxidant action of Yukmijihwang-tang
/ 동의생리병리학회지
/ 한의병리학회
17(2)
: 436~442
[journal]
Jeong JC
/ 1997
/ Increased antioxidant enzyme activities and scavenging effects of oxygen free radicals by Cheongahwan
/ Journal of Korean Medicine
18(2)
: 355~365
[journal]
서영은
/ 2003
/
Antioxidant effects of the Herbs composing Yukmijihwang-tang on PC12 Cell
/ 동의생리병리학회지
/ 한의병리학회
17(1)
: 202~207
[journal]
이귀희
/ 2012
/
Evaluation of Anti-Inflammatory Effects of Yukmijihwangtang and Individual Drug Substances Based on the Extraction Methods
/ 대한한방부인과학회지
/ 대한한방부인과학회
25(2)
: 89~107
[journal]
김민수
/ 2003
/
Effect of Chungajihwangtang on Osteoporosis in Ovariectomized Rats
/ 대한본초학회지
/ 대한본초학회
18(2)
: 49~58
[journal]
Velioglu YS
/ 1998
/ Antioxidant activity and total phenolics in selected fruits, vegetables, and grain products
/ J Agric Food Chem
46(10)
: 4113~4117
[journal]
Kandaswami CE
/ 1994
/ Free Radical Scavenging and Antioxidant Activity of Plant Flavonoids
/ Adv Exp Med Biol
366
: 351~376
[journal]
Carmichael J
/ 1987
/ Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity
/ Cancer Res
47(4)
: 943~946
[journal]
Gheldof N
/ 2002
/ Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples
/ J Agric Food Chem
50(10)
: 3050~3055
[journal]
Choi BK
/ 2004
/ Reactive Oxygen Substances and Diseases
/ Shinil Publishing INC
1
: 7~15
[journal]
Park SN
/ 1997
/ Skin aging and antioxidants
/ Kor.J.Soc Cosmetic Chem
23
: 75~132
[journal]
Stadtman ER
/ 1998
/ Reactive oxygenmediated protein oxidation in aging and disease
/ Drug Metab Rev
30(2)
: 325~343
[journal]
Virag L
/ 2003
/ Peroxynitrite induced cytotoxicity: mechanism and opportunities for intervention
/ Toxicol Lett
140(1)
: 113~124
[journal]
Omata N
/ 2001
/ Increased oxidative stress in childhood atopic dermatitis
/ Life Science
69
: 223~228
[journal]
Knight JA
/ 2000
/ The biochemistry of aging
/ Adv Clin Chem
35
: 1~62
[book]
Goldberg I
/ 1994
/ Functional foods
/ Chapman&Hall Press
: 3~550
[journal]
Valko M
/ 2006
/ Free radicals, metals and antioxidants in oxidative stressinduced cancer
/ Chem Biol Interact
160
: 1~40
[journal]
김민정
/ 2012
/
Antioxidant and Antigenotoxic Effects of Shiitake Mushrooms Affected by Different Drying Methods
/ 한국식품영양과학회지
/ 한국식품영양과학회
41(8)
: 1041~1048
[book]
Hwang TY
/ 1989
/ Bangyakhappyeon
/ Namsandang
: 216~217
[book]
Hong WS
/ 1993
/ Huangjenaegyeongsomun
/ Institute of Traditional Culture
: 19~46
[journal]
Lee ES
/ 2004
/ Inhibition of nitric oxide and tumor necrosis factor-α production by propenone compound through blockade of nuclear factor (NF)-kB activation in cultured murine macrophage
/ Biol Pharm Bull
27
: 617~620
[journal]
Lin CH
/ 2013
/ Immunomodulatory effect of chinese herbal medicine formula sheng-fei-yu-chuan-tang in lipopolysaccharide-induced acute lung injury mice
/ Evid Based Complement Alternat Med
2013
: 976342~
[journal]
Mathiak G
/ 2000
/ Caspase-1-inhibitor ac-YVAD-cmk reduces LPS lethality in rats without affecting haematology or cytokine responses
/ Br J Pharmacol
131(3)
: 383~386
[journal]
Dai J
/ 2010
/ Plant phenolics: Extraction, analysis and their antioxidant and anticancer properties
/ Molecules
15
: 7313~7352
[journal]
Labuza TP
/ 1973
/ Kinetic of lipid oxidation in foods
/ CRS critical Rev. Food Technol
: 335~
[journal]
Meenakshi S
/ 2012
/ In vitro antioxidant properties and FTIR analysis of two seaweeds of Gulf of Mannar
/ Asian Pac J Trop Med
: 66~70
[journal]
Bredt DS
/ 1992
/ Nitric oxide, a novel neuronal messenger
/ Neuron
8
: 3~11
[journal]
Ryu, JH
/ 2003
/ Inhibitory activity of plant extracts on nitric oxide synthesis in LPS- activated macrophage
/ Phytother Res
17
: 485~489
[journal]
Fiers W
/ 1999
/ More than one way to die: apoptosis, necrosis and reactive oxygen damage
/ Oncogene
18(54)
: 7719~7730
[journal]
최원희
/ 2005
/
Antioxidative and Protective Effects of Ulmus davidiana var. japonica Extracts on Glutamate-Induced Cytotoxicity in PC 12 Cells
/ 한국식품과학회지
/ 한국식품과학회
37(3)
: 479~483