2016, Vol.26, No.3

Effects of Seungseup-tang on MIA-induced Osteoarthritis Rats

Jong-Hoon Lee , Chang-Hoon Woo , Young Jun Kim and 1 other persons | 2016, 26(3) | pp.1~15 | number of Cited : 4

Objectives: This study was designed to evaluate the anti-inflammatory effects of Seungseup-tang (SST) on the monosodium iodoacetate (MIA)-induced osteoarthritis rats. Methods: Osteoarthritis was induced by injection of MIA (50 μl with 80 mg/ml) into knee joint cavity of rats. Rats were divided into 4 groups (normal group, control group, in-domethacin treated group, SST treated group, each n=6). Normal group was not injected with MIA and taken normal diet. Control group was injected with MIA and taken with dis-tilled water. Indomethacin treated group was injected with MIA and taken indomethacin 5 mg/kg by oral administration. SST treated group was injected with MIA and taken SST 200 mg/kg by oral administration. We examined the weight-bearing ability of hind paw, bio-markers related to oxidative stress in serum, inflammatory proteins and inflammatory medi-ators and cytokines. Moreover, histopathological examination of knee joint structure was also performed by Hematoxylin & Eosin (H&E), Safranin-O staining method. Results: In the present study, SST treated group showed a similar inhibitory effects alike indomethacin treated group, in most of the studied parameters of inflammation. The in-creased oxidative stress biomarker such as reactive oxygen species (ROS) and peroxy ni-trite (ONOO−) in the serum were reduced with SST. Especially, the level of ONOO− com-pared with control group significantly suppressed. Also, the expression of inflammatory mediators and cytokines induced by nuclear factor-kappa B (NF-κB) activation was modulated through inhibition of IkBaphosphorlation. In addition, histological analysis re-vealed that cartilage damage by MIA repaired markedly in SST treated group.Conclusions: According to the results, Seungseup-tang may be effective for preventing the progression of osteoarthritis. (J Korean Med Rehabil 2016;26(3):1-15)

Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model

원정윤 , Ji-Won Jeong , Na Changsu and 1 other persons | 2016, 26(3) | pp.17~30 | number of Cited : 6

Effects of Joaguihwan (JGH, 左歸丸) Extract on Changes of Anti-oxidation, Anti-inflammatory in RAW 264.7 Cells and on Factors Related with Bone Metabolism in Skull Fractured Rat

Yu-Chen Li , Minseok Oh | 2016, 26(3) | pp.31~49 | number of Cited : 3

ObjectivesThe study was designed to evaluate the healing effects of Joaguihwan (JGH) extract on Anti-oxidation, Anti-inflammatory in RAW 264.7 Cells and factors related with bone metabolism in skull fractured Rat.MethodsThe fracture healing effect of JGH was measured by scavenging activities of1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) and nitric oxide (NO) in RAW 264.7 cells. The inhibitory effect against the pro-duction of inflammatory mediators including interleukin-1β (IL-1β), interleukin-6 (IL-6), tu-mor necosis factors-α (TNF-α) expression was inhibited in RAW 264.7 cells was ex-perimented using JGH. The effects of JGH on healing fractured rats was measured by os-teocalcin, calcitonin, CTXII, TGF-β, BMP-2, Insulin, ALP in the serum. and was checked every 3 weeks from 0 week to 6week using x-ray.Results1. DPPH free radica and ABTS scavenging activity of JGH were increased ac-cording to concentration of JGH in RAW 264.7 Cells. 2. In the experiment, NO, IL-1β, IL-6, TNF-α all showed decrease, in general. Especially NO and IL-1β showed significantly de-crease at a concentration of 10, 100 (μg/ml). 3. In the production of osteocalcin in the se-rum, JGH 200, 400 mg/kg experimental group showed significant increased effect at 2 weeks. 4. In the production of calcitonin in the serum. JGH 200 mg/kg experimental group showed significant increased effect at 4, 6 weeks. JGH 400 mg/kg experimental group showed significant increased effect at 2, 4, 6 weeks. 5. In the production of CTX, TGF-β, BMP-2 in the serum, experimental group showed increased effect. but no significant effect. 6. In the production of insulin in the serum. JGH 200, 400 mg/kg experimental group showed significant decrease effect at 2, 4, 6 weeks. 7. In the production of ALP in the serum. JGH 200 mg/kg experimental group showed significant increased effect at 2, 4, 6 weeks. JGH 400 mg/kg experimental group showed significant increased effect at 4, 6 weeks. 8. In the change of X-ray, the experimental group showed better healing effects on skull fractured rats than control group.ConclusionsFrom above results, JGH showed healing effect on Anti-oxidation, Anti-in-flammatory in RAW 264.7 Cells, factors related with bone metabolism in the serum of skull fractured rat and x-ray, which is expected to be applied in clinics. (J Korean Med Rehabil 2016;26(3):31-49)

Anti-Oxidative and Anti-Inflammatory Effects of Cheongajihwang-Tang Extract on RAW264.7 Cells

윤정원 , 김순중 , 박동수 | 2016, 26(3) | pp.51~58 | number of Cited : 1

Domestic Research Trend of the Ossicification of the Posterior Longitudinal Ligament in Korean Medicine

안민윤 , Lim Hyung Ho | 2016, 26(3) | pp.59~65 | number of Cited : 3

Systematic Review of Bee Venom Therapy for Traumatic Injury

이재은 , 이치호 , Eun-Jung Lee and 2 other persons | 2016, 26(3) | pp.67~77 | number of Cited : 7

Chuna Manual Therapy for Primary Insomnia; A Review of Clinical Study

황만석 | 2016, 26(3) | pp.79~84 | number of Cited : 2

A Study on Research for Utilization Acupuncture Treatment in Military Medicine

최희승 , Yun-Yeop Cha | 2016, 26(3) | pp.85~95 | number of Cited : 1

Effectiveness of Korean Medicine Treatment on Lumbar Intervertebral Disc Herniation Patients’ Fear-Avoidance Belief

최영준 , 문병헌 , 주영국 and 5 other persons | 2016, 26(3) | pp.97~108 | number of Cited : 0

The Correlation between Cross-sectional Area of Lumbar Paraspinal Muscles and Walking Ability in the Patients with Lumbar Spinal Stenosis

김민철 , 서영훈 , 이상민 and 7 other persons | 2016, 26(3) | pp.109~117 | number of Cited : 3

Effect of E10 on Relief of Cervical Myalgia; One Group Pre-Post, Pilot Trial Study

정동훈 , 김혜정 , 김정섭 and 3 other persons | 2016, 26(3) | pp.119~128 | number of Cited : 0

Selection of Manageable Diseases for Quality Assessment in Korean Medicine by Delphi Method

박창현 , Lim Hyung Ho | 2016, 26(3) | pp.129~141 | number of Cited : 0

ObjectivesAs awareness of the public about Korean medicine health care and the social demand about improvement for quality of health care service is constantly rising, the quality evaluation of Korean medicine health care service is needed to improve the quality. Through trial of Delphi method, we tried to set the priority in short, medium, long term among the disease which is the subject of quality assessment.MethodsCarrying out the delphi survey to 50 experts of korean medicine who were rec-ommended by the 41 member societies of Korean medicine and related organizations, we selected final candidates for quality assessment. It is composed with total 2 rounds, and we investigated the priority in three aspects; the importance of the matter, possibility quality assessment, potential about if there's any chance of improvement.ResultsBy delphi method, we set the priority of quality assessment. Base on the result of the second round, we classified importance of the questions into above average, average, below average, and categorized items as short, medium, long term according on the final priority. We classified of musculoskeletal diseases and diseases of connective tissues and musculoskeletal injury as short term and cerebrovascular disease and disease of nerve sys-tem and malignant neoplasm as medium term, disease of digestive organs and diseases, symptoms and abnormal findings in clinical field or inspections which are not categorized as long term.ConclusionsWe set the subjects of quality assessment by delphi survey by experts, and classified into short, medium, long term. Further research is necessary for execution the Quality Assessment to each of the candidate. Also, we can send feedback to medical in-stitution base on the result of Quality Assessment. then it would be able to induce the im-provement in quality of medical institution by itself. (J Korean Med Rehabil 2016;26(3): 129-141)

A Case Report of Complex Korean Medical Treatment for Cervical Spinal Cord Injury and Neurogenic Bladder

송민영 , Jo Hee Geun , 김태광 and 1 other persons | 2016, 26(3) | pp.143~151 | number of Cited : 5

A Rehabilitation for Total Hip Replacement in Korean Medicine: A Report of Three Cases

하원배 , 이종하 , Ko YounSeok and 1 other persons | 2016, 26(3) | pp.153~164 | number of Cited : 15

The Clinical Reaction Study on 64 Cases with Essential Bee Venom Treatment

전용태 , 고 웅 , 김성문 and 4 other persons | 2016, 26(3) | pp.165~170 | number of Cited : 1

The Case Report of Chronic Ankle Sprain Improved with Hominis Placenta Pharmacopuncture Treatment

이동은 , 박원형 , 차윤엽 | 2016, 26(3) | pp.171~181 | number of Cited : 5

A Case of Therapeutic Laser for Suggested Drug Induced Liver Injury Patient during Treatment of Korean Medicine

Lim KyeongTae , Shin, Byung Cheul , Hwang Eui-hyoung and 3 other persons | 2016, 26(3) | pp.183~189 | number of Cited : 1

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Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6

2016, Vol.26, No.3