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Effects of Seungseup-tang on MIA-induced Osteoarthritis Rats

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2016, 26(3), pp.1-15
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

Jong-Hoon Lee 1,  Chang-Hoon Woo 1,  Young Jun Kim 1,  Hee Duk An 2

1대구한의대학교 한의과대학 한방재활의학과교실
2대구한의대학교

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ABSTRACT

Objectives: This study was designed to evaluate the anti-inflammatory effects of Seungseup-tang (SST) on the monosodium iodoacetate (MIA)-induced osteoarthritis rats. Methods: Osteoarthritis was induced by injection of MIA (50 μl with 80 mg/ml) into knee joint cavity of rats. Rats were divided into 4 groups (normal group, control group, in-domethacin treated group, SST treated group, each n=6). Normal group was not injected with MIA and taken normal diet. Control group was injected with MIA and taken with dis-tilled water. Indomethacin treated group was injected with MIA and taken indomethacin 5 mg/kg by oral administration. SST treated group was injected with MIA and taken SST 200 mg/kg by oral administration. We examined the weight-bearing ability of hind paw, bio-markers related to oxidative stress in serum, inflammatory proteins and inflammatory medi-ators and cytokines. Moreover, histopathological examination of knee joint structure was also performed by Hematoxylin & Eosin (H&E), Safranin-O staining method. Results: In the present study, SST treated group showed a similar inhibitory effects alike indomethacin treated group, in most of the studied parameters of inflammation. The in-creased oxidative stress biomarker such as reactive oxygen species (ROS) and peroxy ni-trite (ONOO−) in the serum were reduced with SST. Especially, the level of ONOO− com-pared with control group significantly suppressed. Also, the expression of inflammatory mediators and cytokines induced by nuclear factor-kappa B (NF-κB) activation was modulated through inhibition of IkBaphosphorlation. In addition, histological analysis re-vealed that cartilage damage by MIA repaired markedly in SST treated group.Conclusions: According to the results, Seungseup-tang may be effective for preventing the progression of osteoarthritis. (J Korean Med Rehabil 2016;26(3):1-15)

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