@article{ART002129222},
author={원정윤 and Ji-Won Jeong and Na Changsu and Kim Seon Jong},
title={Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2016},
volume={26},
number={3},
pages={17-30}
TY - JOUR
AU - 원정윤
AU - Ji-Won Jeong
AU - Na Changsu
AU - Kim Seon Jong
TI - Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model
JO - Journal of Korean Medicine Rehabilitation
PY - 2016
VL - 26
IS - 3
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 17
EP - 30
SN - 1229-1854
AB - ObjectivesThe purpose of this study was to find out the effects of ChondroT on arthral-gia of the Collagenase-induced osteoarthritis in rats.MethodsOsteoarthritis was induced into rat by injecting Collagenase in its knee joint. Rats are divided into a total of 8 groups (n=6). Normal group was not induced for osteo-arthritis whereas control groups were induced for osteoarthritis by Collagenase. Positive-A (Indomethacin) was injected with Collagenase and after 8 days, 2 mg/kg of Indomethacin was medicated. Positive-B (JOINS TAB) was injected with Collagenase and after 8 days, 20 mg/kg of JOINS TAB was medicated. Experimental groups (Chondro T) at three dose levels (50, 100 and 200 mg/kg) were injected with Collagenase and after 8days they were medi-cated with 10 ml/kg. Indomethacin, JOINS TAB and ChondroT were medicated each sub-stances once a day for 10 days. Thereafter, the changes in plantar withdrawal response of osteoarthritis rats by dynamic plantar aesthesiometer were observed and then RT-PCR analysis was done to investigate the expression of related proteins.Results1. ChondroT significantly decreased withdrawal response of mechanical allody-nia compared with control group in all of the experimental groups (ChondroT-A, ChondroT-B, ChondroT-C). 2. ChondroT significantly reduced Bax/Bcl-2 ratio in all of the experimental groups (ChondroT-A, ChondroT-B, ChondroT-C). 3. ChondroT significantly reduced the expression of INF-γ compared with control group in group ChondroT-B, ChondroT-C.ConclusionsThis results suggest that ChondroT may be meaningful for suppressing the pain of osteoarthritis. Further study is needed to conduct a rigorous clinical research. (J Korean Med Rehabil 2016;26(3):17-30)
KW - ChondroT;Analgesic effect;Collagenase;Osteoarthritis
DO -
UR -
ER -
원정윤, Ji-Won Jeong, Na Changsu and Kim Seon Jong. (2016). Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model. Journal of Korean Medicine Rehabilitation, 26(3), 17-30.
원정윤, Ji-Won Jeong, Na Changsu and Kim Seon Jong. 2016, "Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model", Journal of Korean Medicine Rehabilitation, vol.26, no.3 pp.17-30.
원정윤, Ji-Won Jeong, Na Changsu, Kim Seon Jong "Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model" Journal of Korean Medicine Rehabilitation 26.3 pp.17-30 (2016) : 17.
원정윤, Ji-Won Jeong, Na Changsu, Kim Seon Jong. Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model. 2016; 26(3), 17-30.
원정윤, Ji-Won Jeong, Na Changsu and Kim Seon Jong. "Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model" Journal of Korean Medicine Rehabilitation 26, no.3 (2016) : 17-30.
원정윤; Ji-Won Jeong; Na Changsu; Kim Seon Jong. Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model. Journal of Korean Medicine Rehabilitation, 26(3), 17-30.
원정윤; Ji-Won Jeong; Na Changsu; Kim Seon Jong. Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model. Journal of Korean Medicine Rehabilitation. 2016; 26(3) 17-30.
원정윤, Ji-Won Jeong, Na Changsu, Kim Seon Jong. Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model. 2016; 26(3), 17-30.
원정윤, Ji-Won Jeong, Na Changsu and Kim Seon Jong. "Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model" Journal of Korean Medicine Rehabilitation 26, no.3 (2016) : 17-30.
2,
Kim Seon Jong
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