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Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2016, 26(3), pp.17-30
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

원정윤 1 Ji-Won Jeong 1 Na Changsu ORD ID 2 Kim Seon Jong 1

1동신대학교 한의과대학 한방재활의학과교실
2동신대학교

Accredited

ABSTRACT

ObjectivesThe purpose of this study was to find out the effects of ChondroT on arthral-gia of the Collagenase-induced osteoarthritis in rats.MethodsOsteoarthritis was induced into rat by injecting Collagenase in its knee joint. Rats are divided into a total of 8 groups (n=6). Normal group was not induced for osteo-arthritis whereas control groups were induced for osteoarthritis by Collagenase. Positive-A (Indomethacin) was injected with Collagenase and after 8 days, 2 mg/kg of Indomethacin was medicated. Positive-B (JOINS TAB) was injected with Collagenase and after 8 days, 20 mg/kg of JOINS TAB was medicated. Experimental groups (Chondro T) at three dose levels (50, 100 and 200 mg/kg) were injected with Collagenase and after 8days they were medi-cated with 10 ml/kg. Indomethacin, JOINS TAB and ChondroT were medicated each sub-stances once a day for 10 days. Thereafter, the changes in plantar withdrawal response of osteoarthritis rats by dynamic plantar aesthesiometer were observed and then RT-PCR analysis was done to investigate the expression of related proteins.Results1. ChondroT significantly decreased withdrawal response of mechanical allody-nia compared with control group in all of the experimental groups (ChondroT-A, ChondroT-B, ChondroT-C). 2. ChondroT significantly reduced Bax/Bcl-2 ratio in all of the experimental groups (ChondroT-A, ChondroT-B, ChondroT-C). 3. ChondroT significantly reduced the expression of INF-γ compared with control group in group ChondroT-B, ChondroT-C.ConclusionsThis results suggest that ChondroT may be meaningful for suppressing the pain of osteoarthritis. Further study is needed to conduct a rigorous clinical research. (J Korean Med Rehabil 2016;26(3):17-30)

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