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Stability of Danggwisu-san (Dangguixu-san) Water Extract, a Herbal Medicine, Under Various Storage Conditions

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2016, 26(4), pp.1-8
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

Ho-Jeong Do 1 신예슬 1 이재환 1 안용준 1 In-Hyuk Ha 2 Yoon-Jae Lee 2 김미령 2 고원일 1 송설희 2 정화진 2 Lee In Hee 2 이재웅 2 김은지 2 김민정 2

1자생한방병원
2자생의료재단

Accredited

ABSTRACT

ObjectivesDanggwisu-san (Dangguixu-san) is a herbal prescription frequently used to treat pain or swelling caused by contusion. To determine the expiration period through sci-entific methodology, stability of Danggwisu-san (Dangguixu-san) water extract, a herbal medicine, was examined under various storage conditions and periods.MethodsDanggwisu-san (Dangguixu-san) was stored either at room temperature (23±2oC), under a refrigerating condition (4oC) or under a freezing condition (−18±2oC) for 0, 1, 2, 3 or 4 weeks and then freeze-dried. Total phenol and total flavonoid amounts were in-vestigated; contents of amygdalin (Prunus persica), paeoniflorin (Paeonia lactiflora), and gly-cyrrhizin (Glycyrrhiza uralensis) - the marker compounds of Danggwisu-san (Dangguixu-san) - were also analyzed through high performance liquid chromatography (HPLC).ResultsNo significant change in total phenol and total flavonoid amounts was observed under the indicated storage conditions. Moreover, the contents of marker compounds, i.e. amygdalin, paeoniflorin, and glycyrrhizin, did not alter significantly under the indicated con-ditions, as well.ConclusionsDanggwisu-san (Dangguixu-san) was found to be stable up until 4 weeks under the indicated conditions. Further studies on efficacy and long-term stability are war-ranted to establish the expiration period of Danggwisu-san (Dangguixu-san). (J Korean Med Rehabil 2016;26(4):1-8)

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