KJCKorea
Journal Central

@article{ART002216551},
author={서일복 and Jeong， Su-hyeon and 박동수},
title={Inhibitory Effects of Daeyeoungjeon on the Injury of Articular Cartilage Induced by Monosodium Iodoacetate in Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2017},
volume={27},
number={2},
pages={9-17}

TY - JOUR
AU - 서일복
AU - Jeong， Su-hyeon
AU - 박동수
TI - Inhibitory Effects of Daeyeoungjeon on the Injury of Articular Cartilage Induced by Monosodium Iodoacetate in Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2017
VL - 27
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 9
EP - 17
SN - 1229-1854
AB - ObjectivesThis study was aimed to evaluate the effects of Daeyoungjeon (hereinafter re-ferred to DYJ) treatment on the injury of articular cartilage induced by monosodium iodoa-cetate in rats.MethodsTwenty-four male rats were divided into normal, osteoarthritic control and DYJ group. Rats of normal group were injected with 0.1 ml physiological saline, rats of control and DYJ groups were injected with 0.1 ml monosodium iodoacetate (3 mg/ml) into each left and right knee joint cavities. Rats of DYJ group were administrated extracts of DYJ during 60 days per orally. At 60 days after treatment, gross lesions, area and proteoglycan con-tents of articular cartilage, histopathological lesions, immunohistochemistry on matrix met-alloproteinases (MMP-2, MMP-3, MMP-7) were evaluated.ResultsGrossly, degenerative changes of articular cartilages were observed weak in DYJ group. The areas of articular cartilages were broader significantly in DYJ group. The proteoglycan contents in articular cartilages were lesser significantly in DYJ group. Histopathologically, the chondrocyte score was lesser significantly in DYJ group. MMP-3 expression in articular cartilages was observed weak in DYJ group.ConclusionsFrom above results, DYJ treatment has inhibitory effects on the injuries of articular cartilage induced by monosodium iodoacetate in rats, and it's effects may be re-lated with down regulation of MMP-3. (J Korean Med Rehabil 2017;27(2):9-17)
KW - Daeyoungjeon (DYJ);Osteoarthritis;Proteoglycan;Matrix metalloproteinase-3
DO -
UR -
ER -

서일복, Jeong， Su-hyeon and 박동수. (2017). Inhibitory Effects of Daeyeoungjeon on the Injury of Articular Cartilage Induced by Monosodium Iodoacetate in Rats. Journal of Korean Medicine Rehabilitation, 27(2), 9-17.

서일복, Jeong， Su-hyeon and 박동수. 2017, "Inhibitory Effects of Daeyeoungjeon on the Injury of Articular Cartilage Induced by Monosodium Iodoacetate in Rats", Journal of Korean Medicine Rehabilitation, vol.27, no.2 pp.9-17.

서일복, Jeong， Su-hyeon, 박동수 "Inhibitory Effects of Daeyeoungjeon on the Injury of Articular Cartilage Induced by Monosodium Iodoacetate in Rats" Journal of Korean Medicine Rehabilitation 27.2 pp.9-17 (2017) : 9.

서일복, Jeong， Su-hyeon, 박동수. Inhibitory Effects of Daeyeoungjeon on the Injury of Articular Cartilage Induced by Monosodium Iodoacetate in Rats. 2017; 27(2), 9-17.

서일복, Jeong， Su-hyeon and 박동수. "Inhibitory Effects of Daeyeoungjeon on the Injury of Articular Cartilage Induced by Monosodium Iodoacetate in Rats" Journal of Korean Medicine Rehabilitation 27, no.2 (2017) : 9-17.

서일복; Jeong， Su-hyeon; 박동수. Inhibitory Effects of Daeyeoungjeon on the Injury of Articular Cartilage Induced by Monosodium Iodoacetate in Rats. Journal of Korean Medicine Rehabilitation, 27(2), 9-17.

서일복; Jeong， Su-hyeon; 박동수. Inhibitory Effects of Daeyeoungjeon on the Injury of Articular Cartilage Induced by Monosodium Iodoacetate in Rats. Journal of Korean Medicine Rehabilitation. 2017; 27(2) 9-17.

서일복, Jeong， Su-hyeon, 박동수. Inhibitory Effects of Daeyeoungjeon on the Injury of Articular Cartilage Induced by Monosodium Iodoacetate in Rats. 2017; 27(2), 9-17.

서일복, Jeong， Su-hyeon and 박동수. "Inhibitory Effects of Daeyeoungjeon on the Injury of Articular Cartilage Induced by Monosodium Iodoacetate in Rats" Journal of Korean Medicine Rehabilitation 27, no.2 (2017) : 9-17.