@article{ART002339800},
author={Ju-yeong Park and Yong-su Na and Gong-cheon Oh and Sang-mi Lee and Byeong-kwon Choi and Yoon-seung Lee and SONG YUNG SUN},
title={A Study on Antibacterial Activity of Daehwanggeonwoo-san(Dahwangqianniu-san) Ethanol Extract against Methicillin-Resistant Staphylococcus Aureus},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2018},
volume={28},
number={2},
pages={21-35},
doi={10.18325/jkmr.2018.28.2.21}
TY - JOUR
AU - Ju-yeong Park
AU - Yong-su Na
AU - Gong-cheon Oh
AU - Sang-mi Lee
AU - Byeong-kwon Choi
AU - Yoon-seung Lee
AU - SONG YUNG SUN
TI - A Study on Antibacterial Activity of Daehwanggeonwoo-san(Dahwangqianniu-san) Ethanol Extract against Methicillin-Resistant Staphylococcus Aureus
JO - Journal of Korean Medicine Rehabilitation
PY - 2018
VL - 28
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 21
EP - 35
SN - 1229-1854
AB - Objectives The objective of this study is to determine the antimicrobial effect of Daehwanggyeonu-san(Dahwangqianniu-san,DGE) and synergistic effects with antibiotics oxacillin, ampicillin, and gentamicin against Methicillin-Resistant Staphylococcus aureus(MRSA).
Methods The antibacterial activity of DGE extract was evaluated againest MRSA strains by using the Disc diffusion method, broth microdilution method(minimal inhibitory concentration; MIC), checkerboard dilution test. The checkerboard dilution test was used to examined synergetic effect of oxacillin, ampicillin, gentamicin, ciprofloxacin with DGE extract.
Results DGE showed antimicrobial activity against MRSA with an MIC value of 125∼250 μg/mL. In the checkerboard test, the interation of DGE with all tested antibiotics produced almost synergy or partial synergy against MRSA.
Conclusions This study shows that DGE reduced the MICs of several antibiotics tested, and a remarkable antibacterial effect of DGE, with membrane permeability enhancers and ATP synthase inhibitors. This study can be a valuable source for the development of a new drug with low MRSA resistance. (J Korean Med Rehabil 2018;28(2):21-35)
KW - Daehwanggyeonu-san(Dahwangqianniu-san;DGE);methicillin-resistant Staphylococcus aureus(MRSA);antibacterial effect;MIC.
DO - 10.18325/jkmr.2018.28.2.21
ER -
Ju-yeong Park, Yong-su Na, Gong-cheon Oh, Sang-mi Lee, Byeong-kwon Choi, Yoon-seung Lee and SONG YUNG SUN. (2018). A Study on Antibacterial Activity of Daehwanggeonwoo-san(Dahwangqianniu-san) Ethanol Extract against Methicillin-Resistant Staphylococcus Aureus. Journal of Korean Medicine Rehabilitation, 28(2), 21-35.
Ju-yeong Park, Yong-su Na, Gong-cheon Oh, Sang-mi Lee, Byeong-kwon Choi, Yoon-seung Lee and SONG YUNG SUN. 2018, "A Study on Antibacterial Activity of Daehwanggeonwoo-san(Dahwangqianniu-san) Ethanol Extract against Methicillin-Resistant Staphylococcus Aureus", Journal of Korean Medicine Rehabilitation, vol.28, no.2 pp.21-35. Available from: doi:10.18325/jkmr.2018.28.2.21
Ju-yeong Park, Yong-su Na, Gong-cheon Oh, Sang-mi Lee, Byeong-kwon Choi, Yoon-seung Lee, SONG YUNG SUN "A Study on Antibacterial Activity of Daehwanggeonwoo-san(Dahwangqianniu-san) Ethanol Extract against Methicillin-Resistant Staphylococcus Aureus" Journal of Korean Medicine Rehabilitation 28.2 pp.21-35 (2018) : 21.
Ju-yeong Park, Yong-su Na, Gong-cheon Oh, Sang-mi Lee, Byeong-kwon Choi, Yoon-seung Lee, SONG YUNG SUN. A Study on Antibacterial Activity of Daehwanggeonwoo-san(Dahwangqianniu-san) Ethanol Extract against Methicillin-Resistant Staphylococcus Aureus. 2018; 28(2), 21-35. Available from: doi:10.18325/jkmr.2018.28.2.21
Ju-yeong Park, Yong-su Na, Gong-cheon Oh, Sang-mi Lee, Byeong-kwon Choi, Yoon-seung Lee and SONG YUNG SUN. "A Study on Antibacterial Activity of Daehwanggeonwoo-san(Dahwangqianniu-san) Ethanol Extract against Methicillin-Resistant Staphylococcus Aureus" Journal of Korean Medicine Rehabilitation 28, no.2 (2018) : 21-35.doi: 10.18325/jkmr.2018.28.2.21
Ju-yeong Park; Yong-su Na; Gong-cheon Oh; Sang-mi Lee; Byeong-kwon Choi; Yoon-seung Lee; SONG YUNG SUN. A Study on Antibacterial Activity of Daehwanggeonwoo-san(Dahwangqianniu-san) Ethanol Extract against Methicillin-Resistant Staphylococcus Aureus. Journal of Korean Medicine Rehabilitation, 28(2), 21-35. doi: 10.18325/jkmr.2018.28.2.21
Ju-yeong Park; Yong-su Na; Gong-cheon Oh; Sang-mi Lee; Byeong-kwon Choi; Yoon-seung Lee; SONG YUNG SUN. A Study on Antibacterial Activity of Daehwanggeonwoo-san(Dahwangqianniu-san) Ethanol Extract against Methicillin-Resistant Staphylococcus Aureus. Journal of Korean Medicine Rehabilitation. 2018; 28(2) 21-35. doi: 10.18325/jkmr.2018.28.2.21
Ju-yeong Park, Yong-su Na, Gong-cheon Oh, Sang-mi Lee, Byeong-kwon Choi, Yoon-seung Lee, SONG YUNG SUN. A Study on Antibacterial Activity of Daehwanggeonwoo-san(Dahwangqianniu-san) Ethanol Extract against Methicillin-Resistant Staphylococcus Aureus. 2018; 28(2), 21-35. Available from: doi:10.18325/jkmr.2018.28.2.21
Ju-yeong Park, Yong-su Na, Gong-cheon Oh, Sang-mi Lee, Byeong-kwon Choi, Yoon-seung Lee and SONG YUNG SUN. "A Study on Antibacterial Activity of Daehwanggeonwoo-san(Dahwangqianniu-san) Ethanol Extract against Methicillin-Resistant Staphylococcus Aureus" Journal of Korean Medicine Rehabilitation 28, no.2 (2018) : 21-35.doi: 10.18325/jkmr.2018.28.2.21