Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6
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pISSN : 1229-1854
- https://journal.kci.go.kr/jkmr
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A Study on Antibacterial Activity of Daehwanggeonwoo-san(Dahwangqianniu-san) Ethanol Extract against Methicillin-Resistant Staphylococcus Aureus
- Journal of Korean Medicine Rehabilitation
- Abbr : JKMR
- 2018, 28(2), pp.21-35
- DOI : 10.18325/jkmr.2018.28.2.21
- Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
- Research Area : Medicine and Pharmacy > Korean Medicine
- Received : March 18, 2018
- Accepted : April 3, 2018
- Published : April 30, 2018
Ju-yeong Park 1, Yong-su Na 1, Gong-cheon Oh 1, Sang-mi Lee 1, Byeong-kwon Choi 1, Yoon-seung Lee 2, SONG YUNG SUN 3
1원광대학교 한의학전문대학원
2원광대학교 한의과대학 한방재활의학교실
3원광대학교
Accredited
ABSTRACT
Objectives The objective of this study is to determine the antimicrobial effect of Daehwanggyeonu-san(Dahwangqianniu-san,DGE) and synergistic effects with antibiotics oxacillin, ampicillin, and gentamicin against Methicillin-Resistant Staphylococcus aureus(MRSA).
Methods The antibacterial activity of DGE extract was evaluated againest MRSA strains by using the Disc diffusion method, broth microdilution method(minimal inhibitory concentration; MIC), checkerboard dilution test. The checkerboard dilution test was used to examined synergetic effect of oxacillin, ampicillin, gentamicin, ciprofloxacin with DGE extract.
Results DGE showed antimicrobial activity against MRSA with an MIC value of 125∼250 μg/mL. In the checkerboard test, the interation of DGE with all tested antibiotics produced almost synergy or partial synergy against MRSA.
Conclusions This study shows that DGE reduced the MICs of several antibiotics tested, and a remarkable antibacterial effect of DGE, with membrane permeability enhancers and ATP synthase inhibitors. This study can be a valuable source for the development of a new drug with low MRSA resistance. (J Korean Med Rehabil 2018;28(2):21-35)
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