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@article{ART002555903},
author={Je-Hoon Won and Chang-Hoon Woo},
title={The Effect of Lonicera japonica Extract in Wound-induced Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2020},
volume={30},
number={1},
pages={47-61},
doi={10.18325/jkmr.2020.30.1.47}

TY - JOUR
AU - Je-Hoon Won
AU - Chang-Hoon Woo
TI - The Effect of Lonicera japonica Extract in Wound-induced Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2020
VL - 30
IS - 1
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 47
EP - 61
SN - 1229-1854
AB - Objectives This study is carried out to investigate the effects of Lonicera japonica in wound-induced rats. Methods Rats were divided into 5 groups; normal (Nor), control (Veh), positive comparison (PC), Lonicera japonica 100 mg/kg (LL), Lonicera japonica 200 mg/kg (LH), each n=8. Total polyphenol and flavonoid were quantified. 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3 ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging activation were measured. Reactive oxygen species (ROS) was measured in serum. Antioxidant factors and inflammatory factors were measured in skin tissue, and also hydroxyproline content. Skin tissue was analyzed by Hematoxylin & Eosin and Masson’s trichrome staining method. Results Total polyphenol and flavonoid were 32.86±0.14 mg/g and 67.17±0.57 mg/g. The IC50 values of DPPH and ABTS free radical scavenging activation were 26.69±1.50 μg/mL and 49.33±4.52 μg/mL. ROS was significantly lower in LL and LH groups. Nuclear factor-erythroid 2-related factor 2 (Nrf2) was significantly higher in LH group and higher in LL group but not significant. Superoxide dismutase 1 (SOD-1), catalase, and heme oxygenase 1 (HO-1) were significantly higher in LL and LH groups. Nuclear factor kappa-B p65 (NF-κBp65), phosphorylated iκBα (p-iκBα), cyclooxygenase 2 (COX-2), and tumor necrosis factor alpha (TNF-α) were significantly lower in LL and LH groups. Hydroxyproline was significantly higher in LL and LH groups. The histopathologic analysis showed that skin tissue had recovered further more in LL and LH groups than in Veh group. Conclusions These results suggest that Lonicera japonica has the anti-oxidant, anti-inflammatory and healing effects in wound-induced rats. (J Korean Med Rehabil 2020; 30(1):47-61)
KW - Lonicera japonica;Antioxidants;Inflammation;Wound healing
DO - 10.18325/jkmr.2020.30.1.47
ER -

Je-Hoon Won and Chang-Hoon Woo. (2020). The Effect of Lonicera japonica Extract in Wound-induced Rats. Journal of Korean Medicine Rehabilitation, 30(1), 47-61.

Je-Hoon Won and Chang-Hoon Woo. 2020, "The Effect of Lonicera japonica Extract in Wound-induced Rats", Journal of Korean Medicine Rehabilitation, vol.30, no.1 pp.47-61. Available from: doi:10.18325/jkmr.2020.30.1.47

Je-Hoon Won, Chang-Hoon Woo "The Effect of Lonicera japonica Extract in Wound-induced Rats" Journal of Korean Medicine Rehabilitation 30.1 pp.47-61 (2020) : 47.

Je-Hoon Won, Chang-Hoon Woo. The Effect of Lonicera japonica Extract in Wound-induced Rats. 2020; 30(1), 47-61. Available from: doi:10.18325/jkmr.2020.30.1.47

Je-Hoon Won and Chang-Hoon Woo. "The Effect of Lonicera japonica Extract in Wound-induced Rats" Journal of Korean Medicine Rehabilitation 30, no.1 (2020) : 47-61.doi: 10.18325/jkmr.2020.30.1.47

Je-Hoon Won; Chang-Hoon Woo. The Effect of Lonicera japonica Extract in Wound-induced Rats. Journal of Korean Medicine Rehabilitation, 30(1), 47-61. doi: 10.18325/jkmr.2020.30.1.47

Je-Hoon Won; Chang-Hoon Woo. The Effect of Lonicera japonica Extract in Wound-induced Rats. Journal of Korean Medicine Rehabilitation. 2020; 30(1) 47-61. doi: 10.18325/jkmr.2020.30.1.47

Je-Hoon Won, Chang-Hoon Woo. The Effect of Lonicera japonica Extract in Wound-induced Rats. 2020; 30(1), 47-61. Available from: doi:10.18325/jkmr.2020.30.1.47

Je-Hoon Won and Chang-Hoon Woo. "The Effect of Lonicera japonica Extract in Wound-induced Rats" Journal of Korean Medicine Rehabilitation 30, no.1 (2020) : 47-61.doi: 10.18325/jkmr.2020.30.1.47