Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6
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pISSN : 1229-1854
- https://journal.kci.go.kr/jkmr
KJCKorea
Journal Central
Epigenetic Modification in Chronic Pain: A Literature Review
- Journal of Korean Medicine Rehabilitation
- Abbr : JKMR
- 2020, 30(1), pp.63-78
- DOI : 10.18325/jkmr.2020.30.1.63
- Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
- Research Area : Medicine and Pharmacy > Korean Medicine
- Received : December 14, 2019
- Accepted : December 31, 2019
- Published : January 31, 2020
Eun-mo Song 1, Hong Seok Cho 2, Kim Koh-Woon 1, Park Hi-Joon 1, Mi-Yeon Song 1
1경희대학교
2경희대학교 한의과대학 한방재활의학과교실
Accredited
ABSTRACT
Objectives To review the epigenetic modifications involved in chronic pain and to improve individualized intervention for the chronic pain.
Methods Focused literature review.
Results Significant laboratory and clinical data support that epigenetic modifications have a potential role for development of chronic pain.
Conclusions Epigenetic approach may identify mechanisms critical to the development of chronic pain after injury, and may provide new pathways and target mechanisms for future treatment and individualized medicine. (J Korean Med Rehabil 2020; 30(1):63-78)
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[journal]
Crofford LJ
/ 2015
/ Chronic pain : where the body meets the brain
/ Transactions of the American Clinical and Climatological Association
126
: 167~183
[journal]
Woolf CJ
/ 2004
/ Pain : moving from symptom control toward mechanism-specific pharmacologic management
/ Annals of Internal Medicine
140(6)
: 441~451
[journal]
Bali KK
/ 2014
/ Noncoding RNAs : key molecules in understanding and treating pain
/ Trends in Molecular Medicine
20(8)
: 437~448
[journal]
Woolf CJ
/ 1999
/ Implications of recent advances in the understanding of pain pathophysiology for the assessment of pain in patients
/ Pain
Suppl 6
: S141~S147
[journal]
Kissin I
/ 2010
/ The development of new analgesics over the past 50 years : a lack of real breakthrough drugs
/ Anesthesia and Analgesia
110(3)
: 780~789
[journal]
Javierre BM
/ 2010
/ Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
/ Genome Research
20(2)
: 170~179
[journal]
Descalzi G
/ 2015
/ Epigenetic mechanisms of chronic pain
/ Trends Neurosci
38(4)
: 237~246
[journal]
Wu C
/ 2001
/ Genes, genetics, and epigenetics : a correspondence
/ Science
293(5532)
: 1103~1105
[journal]
Kouzarides T
/ 2007
/ Chromatin modifications and their function
/ Cell
128(4)
: 693~705
[journal]
Guan Z
/ 2002
/ Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure
/ Cell
111(4)
: 483~493
[journal]
Gregory PD
/ 2001
/ Histone acetylation and chromatin remodeling
/ Experimental Cell Research
265(2)
: 195~202
[journal]
Fan S
/ 2009
/ CpG island methylation pattern in different human tissues and its correlation with gene expression
/ Biochemical and Biophysical Research Communications
383(4)
: 421~425
[journal]
Bartel DP
/ 2004
/ MicroRNAs : genomics, biogenesis, mechanism, and function
/ Cell
116(2)
: 281~297
[journal]
Loeser JD
/ 1999
/ Pain : an overview
/ Lancet
353(9164)
: 1607~1609
[journal]
Petrenko AB
/ 2003
/ The role of N-methyl-D-aspartate(NMDA)receptors in pain : a review
/ Anesth Analg
97(4)
: 1108~1116
[journal]
Sherman SM
/ 1996
/ Functional organization of thalamocortical relays
/ J Neurophysiol
76(3)
: 1367~1395
[journal]
Voisin DL
/ 2005
/ Nociceptive stimulation activates locus coeruleus neurones projecting to the somatosensory thalamus in the rat
/ J Physiol
566(Pt 3)
: 929~937
[journal]
Apkarian AV
/ 2005
/ Human brain mechanisms of pain perception and regulation in health and disease
/ Eur J Pain
9(4)
: 463~484
[journal]
Heinricher MM
/ 2009
/ Descending control of nociception : Specificity, recruitment and plasticity
/ Brain Res Rev
60(1)
: 214~225
[journal]
Tracey I
/ 2007
/ The cerebral signature for pain perception and its modulation
/ Neuron
55(3)
: 377~391
[journal]
Zhuo M
/ 1997
/ Biphasic modulation of spinal nociceptive transmission from the medullary raphe nuclei in the rat
/ J Neurophysiol
78(2)
: 746~758
[journal]
Carlson JD
/ 2007
/ Sensitization of pain-modulating neurons in the rostral ventromedial medulla after peripheral nerve injury
/ J Neurosci
27(48)
: 13222~13231
[journal]
Millan MJ
/ 2002
/ Descending control of pain
/ Progress in Neurobiology
66(6)
: 355~474
[journal]
Jasmin L
/ 2003
/ Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex
/ Nature
424(6946)
: 316~320
[journal]
Yaksh TL
/ 1987
/ Opioid receptor systems and the endorphins : a review of their spinal organization
/ J Neurosurg
67(2)
: 157~176
[journal]
Woolf CJ
/ 2000
/ Neuronal plasticity : increasing the gain in pain
/ Science
288(5472)
: 1765~1769
[journal]
Gureje O
/ 1998
/ Persistent pain and well-being : a World Health Organization Study in Primary Care
/ JAMA
280(2)
: 147~151
[journal]
Muralidharan A
/ 2011
/ Pain, analgesia and genetics
/ The Journal of Pharmacy and Pharmacology
63(11)
: 1387~1400
[journal]
Smith MT
/ 2012
/ Pharmacogenetics of pain and analgesia
/ Clinical genetics
82(4)
: 321~330
[journal]
Seo S
/ 2013
/ Epigenetics : a promising paradigm for better understanding and managing pain
/ The Journal of Pain : Official Journal of the American Pain Society
14(6)
: 549~557
[journal]
Kuner R
/ 2010
/ Central mechanisms of pathological pain
/ Nat Med
16(11)
: 1258~1266
[journal]
Su RC
/ 2008
/ Epigenetic regulation of established human type 1 versus type 2 cytokine responses
/ J Allergy Clin Immunol
121(1)
: 57~63
[journal]
Riccio A
/ 2010
/ Dynamic epigenetic regulation in neurons : enzymes, stimuli and signaling pathways
/ Nature Neuroscience
13(11)
: 1330~1337
[journal]
Hammer P
/ 2010
/ mRNA-seq with agnostic splice site discovery for nervous system transcriptomics tested in chronic pain
/ Genome Res
20(6)
: 847~860
[journal]
Gangadharan V
/ 2013
/ Pain hypersensitivity mechanisms at a glance
/ Dis Model Mech
6(4)
: 889~895
[journal]
Denk F
/ 2012
/ Chronic pain : emerging evidence for the involvement of epigenetics
/ Neuron
73(3)
: 435~444
[journal]
Besson JM
/ 1999
/ The neurobiology of pain
/ Lancet
353(9164)
: 1610~1615
[journal]
McCall CE
/ 2011
/ Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation
/ Journal of Leukocyte Biology
90(3)
: 439~446
[journal]
Fukuoka T
/ 2001
/ Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model
/ The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
21(13)
: 4891~4900
[journal]
Bruce AW
/ 2004
/ Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor(REST/NRSF)target genes
/ Proc Natl Acad Sci U S A
101(28)
: 10458~10463
[journal]
Uchida H
/ 2010
/ Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain
/ The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
30(13)
: 4806~4814
[journal]
Uchida H
/ 2010
/ Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3gene after peripheral nerve injury
/ Neuroscience
166(1)
: 1~4
[journal]
Woolf CJ
/ 2011
/ Central sensitization: implications for the diagnosis and treatment of pain
/ Pain
152(3 Suppl)
: S2~S15
[journal]
Kawasaki Y
/ 2004
/ Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
/ The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
24(38)
: 8310~8321
[journal]
Geranton SM
/ 2007
/ A role for transcriptional repressor methyl-CpG-binding protein 2and plasticity-related gene serum-and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states
/ The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
27(23)
: 6163~6173
[journal]
Shakespear MR
/ 2011
/ Histone deacetylases as regulators of inflammation and immunity
/ Trends Immunol
32(7)
: 335~343
[journal]
Haettig J
/ 2011
/ HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner
/ Learn Mem
18(2)
: 71~79
[journal]
Kiguchi N
/ 2012
/ Epigenetic augmentation of the macrophage inflammatory protein 2/C-X-C chemokine receptor type 2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain
/ J Pharmacol Exp Ther
340(3)
: 577~587
[journal]
Imai S
/ 2013
/ Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain
/ Brain : a Journal of Neurology
136
: 828~843
[journal]
Ito K
/ 2000
/ Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12
/ Mol Cell Biol
20(18)
: 6891~6903
[journal]
Leoni F
/ 2002
/ The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines
/ Proc Natl Acad Sci U S A
99(5)
: 2995~3000
[journal]
Chiechio S
/ 2002
/ L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors
/ Molecular Pharmacology
61(5)
: 989~996
[journal]
Chiechio S
/ 2010
/ Transcriptional regulation of type-2 metabotropic glutamate receptors : an epigenetic path to novel treatments for chronic pain
/ Trends Pharmacol Sci
31(4)
: 153~160
[journal]
Kim CS
/ 2004
/ Neuron-restrictive silencer factor(NRSF)functions as a repressor in neuronal cells to regulate the mu opioid receptor gene
/ The Journal of Biological Chemistry
279(45)
: 46464~46473
[journal]
Crow M
/ 2013
/ Genes and epigenetic processes as prospective pain targets
/ Genome Med
5(2)
: 12~
[journal]
Geranton SM
/ 2008
/ Descending serotonergic controls regulate inflammation-induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn
/ Molecular Pain
4
: 35~
[journal]
Tochiki KK
/ 2012
/ The expression of spinal methyl-CpG-binding protein 2, DNA methyltransferases and histone deacetylases is modulated in persistent pain states
/ Mol Pain
8
: 14~
[journal]
Tajerian M
/ 2011
/ DNA methylation of SPARC and chronic low back pain
/ Mol Pain
7
: 65~
[journal]
Viet CT
/ 2011
/ Re-expression of the methylated EDNRB gene in oral squamous cell carcinoma attenuates cancer-induced pain
/ Pain
152(10)
: 2323~2332
[journal]
LaCroix-Fralish ML
/ 2011
/ Patterns of pain : meta-analysis of microarray studies of pain
/ Pain
152(8)
: 1888~1898
[journal]
Zhao J
/ 2010
/ Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds
/ J Neurosci
30(32)
: 10860~10871
[journal]
Kynast KL
/ 2013
/ Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice
/ Pain
154(3)
: 368~376
[journal]
Sakai A
/ 2013
/ Nerve injury-induced upregulation of miR-21 in the primary sensory neurons contributes to neuropathic pain in rats
/ Biochemical and Biophysical Research Communications
435(2)
: 176~181
[journal]
Willemen HL
/ 2012
/ MicroRNA-124 as a novel treatment for persistent hyperalgesia
/ Journal of Neuroinflammation
9
: 143~
[journal]
Fossat P
/ 2010
/ Knockdown of L calcium channel subtypes : differential effects in neuropathic pain
/ J Neurosci
30(3)
: 1073~1085
[journal]
Favereaux A
/ 2011
/ Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain
/ The EMBO Journal
30(18)
: 3830~3841
[journal]
Sakai A
/ 2013
/ miR-7a alleviates the maintenance of neuropathic pain through regulation of neuronal excitability
/ Brain : A Journal of Neurology
136(Pt 9)
: 2738~2750
[journal]
Chen HP
/ 2014
/ Intrathecal miR-96 inhibits Nav1.3 expression and alleviates neuropathic pain in rat following chronic construction injury
/ Neurochemical Research
39(1)
: 76~83
[journal]
Baliki MN
/ 2012
/ Corticostriatal functional connectivity predicts transition to chronic back pain
/ Nature Neuroscience
15(8)
: 1117~1119
[journal]
Rainville P
/ 2001
/ Representation of acute and persistent pain in the human CNS : potential implications for chemical intolerance
/ Annals of the New York Academy of Sciences
933
: 130~141
[journal]
Apkarian AV
/ 2004
/ Chronic back pain is associated with decreased prefrontal and thalamic gray matter density
/ J Neurosci
24(46)
: 10410~10415
[journal]
Bushnell MC
/ 2013
/ Cognitive and emotional control of pain and its disruption in chronic pain
/ Nature reviews Neuroscience
14(7)
: 502~511
[journal]
Porreca F
/ 2002
/ Chronic pain and medullary descending facilitation
/ Trends in Neurosciences
25(6)
: 319~325
[journal]
Zhang Z
/ 2011
/ Epigenetic suppression of GAD65 expression mediates persistent pain
/ Nat Med
17(11)
: 1448~1455
[journal]
Burgess SE
/ 2002
/ Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain
/ The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
22(12)
: 5129~5136
[journal]
Nasca C
/ 2013
/ L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors
/ Proceedings of the National Academy of Sciences of the United States of America
110(12)
: 4804~4809
[journal]
Tajerian M
/ 2013
/ Peripheral nerve injury is associated with chronic, reversible changes in global DNA methylation in the mouse prefrontal cortex
/ PloS One
8(1)
: e55259~
[journal]
Imai S
/ 2011
/ Change in microRNAs associated with neuronal adaptive responses in the nucleus accumbens under neuropathic pain
/ The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
31(43)
: 15294~15299
[journal]
Poh KW
/ 2011
/ MicroRNA changes in the mouse prefrontal cortex after inflammatory pain
/ Eur J Pain
15(8)
: 801~
[journal]
Cherng CH
/ 2014
/ Baicalin ameliorates neuropathic pain by suppressing HDAC1 expression in the spinal cord of spinal nerve ligation rats
/ J Formos Med Assoc
113(8)
: 513~520
[journal]
Bai G
/ 2010
/ Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia
/ Molecular Pain
6
: 51~
[journal]
Ni J
/ 2013
/ Regulation of mu-opioid type 1 receptors by microRNA134in dorsal root ganglion neurons following peripheral inflammation
/ Eur J Pain
17(3)
: 313~323
[journal]
Buchheit T
/ 2012
/ Epigenetics and the transition from acute to chronic pain
/ Pain Med
13(11)
: 1474~1490
[journal]
Geranton SM
/ 2012
/ Targeting epigenetic mechanisms for pain relief
/ Current Opinion in Pharmacology
12(1)
: 35~41
[journal]
Fu SP
/ 2014
/ Acupuncture promotes angiogenesis after myocardial ischemia through H3K9 acetylation regulation at VEGF gene
/ PloS One
9(4)
: e94604~
[journal]
Wang JY
/ 2015
/ MicroRNA profiling response to acupuncture therapy in spontaneously hypertensive rats
/ Evid Based Complement Alternat Med
2015
: 204367~
[journal]
Wang JY
/ 2015
/ Acupuncture may exert its therapeutic effect through microRNA-339/Sirt2/NFkappaB/FOXO1 axis
/ BioMed Research International
2015
: 249013~
[journal]
Wang N
/ 2015
/ A protocol of histone modification-based mechanistic study of acupuncture in patients with stable angina pectoris
/ BMC Complement Altern Med
15
: 139~
[journal]
Hsieh HY
/ 2011
/ Epigenetics in traditional chinese pharmacy : a bioinformatic study at pharmacopoeia scale
/ Evid Based Complement Alternat Med
2011
: 816714~
[journal]
Hsieh HY
/ 2013
/ Histone modifications and traditional Chinese medicinals
/ BMC Complement Altern Med
13
: 115~
[journal]
Hong M
/ 2015
/ MicroRNAs and Chinese medicinal herbs : new possibilities in cancer therapy
/ Cancers(Basel)
7(3)
: 1643~1657
[journal]
Zhao HL
/ 2012
/ Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression
/ Diabetes
61(4)
: 933~943
[journal]
Zhang Y
/ 2008
/ Proteomic analysis of differential proteins related to the neuropathic pain and neuroprotection in the dorsal root ganglion following its chronic compression in rats
/ Exp Brain Res
189(2)
: 199~209
[journal]
Bai L
/ 2010
/ A cupuncture modulates temporal neural responses in wide brain networks : evidence from fMRI study
/ Molecular Pain
6
: 73~
[journal]
Huang W
/ 2012
/ Characterizing acupuncture stimuli using brain imaging with FMRI--a systematic review and meta-analysis of the literature
/ PloS One
7(4)
: e32960~
[journal]
Gao YH
/ 2012
/ Differential proteomics analysis of the analgesic effect of electroacupuncture intervention in the hippocampus following neuropathic pain in rats
/ BMC Complement Altern Med
12
: 241~
[journal]
Gao Y
/ 2013
/ Proteomic analysis of differential proteins related to anti-nociceptive effect of electroacupuncture in the hypothalamus following neuropathic pain in rats
/ Neurochemical Research
38(7)
: 1467~1478
[journal]
Sun J
/ 2015
/ Electroacupuncture alleviates retrieval of pain memory and its effect on phosphorylation of cAMP response element-binding protein in anterior cingulate cortex in rats
/ Behav Brain Funct
11
: 9~