Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6
-
pISSN : 1229-1854
- https://journal.kci.go.kr/jkmr
KJCKorea
Journal Central
Antioxidative, Anti-inflammatory Effects of Jibaekjihwang-tang (zhibaidihuang-tang) on Osteoarthritic Rat Model
- Journal of Korean Medicine Rehabilitation
- Abbr : JKMR
- 2020, 30(2), pp.1-18
- DOI : 10.18325/jkmr.2020.30.2.1
- Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
- Research Area : Medicine and Pharmacy > Korean Medicine
- Received : March 17, 2020
- Accepted : April 6, 2020
- Published : April 30, 2020
Chang-Yoon Woo
1,
Kim Youngjun
2,
Chang-Hoon Woo
1
1대구한의대학교
2대구한의대학교 한의과대학 한방재활의학과교실
Accredited
ABSTRACT
Objectives This study intended to evaluate antioxidative, anti-inflammatory effects of Jibaekjihwang-tang on monosodium iodoacetate (MIA)-induced osteoarthritic rat model and investigate the potential mechanism.
Methods Jibaekjihwang-tang (100 or 200 ㎎/㎏ body weight) was orally administered once daily for 2 weeks days from day 7 after intra-articular MIA injection. And blood analysis, the histologic examinations were performed. Moreover, protein expressions related to anti-oxidant and cartilage degradation and anti-inflammatory cytokines were measured by western blot analysis in cartilaginous tissue.
Results Jibaekjihwang-tang reduced serum inflammatory cytokines such as tumor necosis factors-α and interleukin-6. Furthermore, the increase of anti-oxidant enzymes reversed the oxidative stress caused by MIA. Meanwhile, Jibaekjihwang-tang suppressed MIA-induced inflammation and cartilage degradation in cartilaginous tissue.
Conclusions Jibaekjihwang-tang alleviated MIA-induced inflammation. Jibaekjihwang-tang was associated with a protective effect on cartilage and by reducing inflammation and cartilage degradation. These findings provide new approaches for understanding osteoarthritis therapy. (J Korean Med Rehabil 2020;30(2):1-18)
Statistics
-
252 Viewed
-
1 Downloaded
Tools
Issue List
Citation status
* References for papers published after 2023 are currently being built.
[book]
The Korean Orthopaedic Association
/ 2013
/ Orthopaedics
/ ChoiSin medical Publishing Co
: 290~
[book]
The Society of Korean Medicine Rehabilitation
/ 2015
/ Korean rehabilitation medicine
/ Koonja Publishing
: 102~116
[journal]
여상범
/ 2011
/
Research Trends on the Treatment of Knee Osteoarthritis in Korean Medicine
/ Korean Journal of Acupuncture
/ 경락경혈학회
28(1)
: 139~155
[book]
Oh K
/ 1983
/ Euijongguemgam
/ Daesung MoonWha Inc
: 49~51
[journal]
이귀희
/ 2012
/
Evaluation of Anti-Inflammatory Effects of Yukmijihwangtang and Individual Drug Substances Based on the Extraction Methods
/ 대한한방부인과학회지
/ 대한한방부인과학회
25(2)
: 89~107
[journal]
이영근
/ 2017
/
Anti-Inflammatory Effect of Anemarrhenae Rhizoma 80% Ethanol Extract in RAW 264.7 cells
/ 대한본초학회지
/ 대한본초학회
32(3)
: 97~103
[journal]
Jang JH
/ 1999
/ 1β inhibitory effect on the expression-yellowish and above the youngseon acupuncture Lipopolysaccharide-induced arthritis in the IL : Literature study
/ J Acupunct Res
16(1)
: 511~531
[book]
Yun YK
/ 1998
/ Donguibangje and cheobanghaeseol
/ Uiseongdang
: 336~337
[journal]
Hatano T
/ 1989
/ Effects of the interaction of tannins with co-existing substances. Ⅵ. Effects if tannins and related polyphenols on superoxide anion radical, and 1,1-diphenyl-2-picrylhydrazyl radical
/ Chem Pharm Bull
37(8)
: 2016~2021
[journal]
Re R
/ 1999
/ Antioxidant activity applying an improved ABTS radical cation decolorization assay
/ Free Radic Biol Med
26(9-10)
: 1231~1237
[journal]
Folin O
/ 1912
/ On phosphotungasticphosphomolybdic compounds as color reagents
/ J Biol Chem
12(2)
: 239~243
[journal]
Lister CE
/ 1994
/ Developmental changes in the concentration and composition of flavonoids in skin of a red and a green apple cultivar
/ Journal of the Science of Food and Agriculture
64(2)
: 155~161
[journal]
Mihara M
/ 1978
/ Determination of malonaldehyde precursor in tissues by thiobarbituric acid test
/ Anal Biochem
86(1)
: 271~278
[journal]
심양수
/ 2004
/
Effects of Aqua-Acupuncture of Jibaikjihwangtang on the Blood Pressure in Hypertensive Rats
/ Journal of Acupuncture Research
/ 대한침구의학회
21(4)
: 1~18
[journal]
이승혜
/ 2017
/
Aqueous Extracts of Jibaekjihwang-tang Ameliorate Ovariectomy-induced Climacterium Symptoms in Mouse
/ 대한한방부인과학회지
/ 대한한방부인과학회
30(2)
: 16~36
[journal]
김현정
/ 2013
/
A Case Report of Progressive Pigmented Purpuric Dermatosis improved with Jibaekjihwang-tang
/ 한방안이비인후피부과학회지
/ 대한한방안이비인후피부과학회
26(2)
: 109~116
[book]
Korean Herbalogy Society
/ 2016
/ Herbalogy
/ Young-lim
: 201~
[journal]
Jung YS
/ 1999
/ Studies on the anti-inflammatory action of teamed Rehmannia glutinosa in central nervous system
/ J of Oriental Neuropsychiatry
10(2)
: 59~70
[journal]
김민주
/ 2019
/
Protective Effect of Dioscoreae Rhizoma Extracts in MIA-induced Rat.
/ 대한본초학회지
/ 대한본초학회
34(4)
: 27~35
[journal]
박성규
/ 2005
/
Antioxidant Effects of Corni Fructus in GC-1 Cells
/ 동의생리병리학회지
/ 한의병리학회
19(6)
: 1541~1545
[journal]
Rios JL
/ 2011
/ Chemical constituents and pharmacological properties of Poria cocos
/ Planta Med
77(7)
: 681~691
[thesis]
유주희
/ 2012
/ 澤瀉와 연관된 국내 문헌의 연구 동향 고찰
/ 석사
/ 원광대학교 대학원
[journal]
Kim DH
/ 1997
/ Effect of moutan radicis cortex on collagen-induced arthritis
/ The Journal of Traditional Korean Medicine
7(2)
: 60~69
[journal]
Kalben DA
/ 1977
/ Hypothesis and experimental confirmation of a new pharmacological model of osteoarthrosis
/ Arzneimittelforschung
27(3)
: 527~531
[journal]
Combe R
/ 2004
/ The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats?
/ Neurosci Lett
370(2-3)
: 236~240
[journal]
Guzman RE
/ 2003
/ Mono-iodoacetate-induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints : an animal model of osteoarthritis
/ Toxicol Pathol
31(6)
: 619~624
[journal]
Song YJ
/ 2009
/ The use of COX-2 selective nonsteroidal anti-inflammatory drugs for the treatment of osteoarthritis
/ J Korean Knee Soc
21(2)
: 84~92
[journal]
Cho YJ
/ 1998
/ Comparison of side effects of non-steroidal antiinflammatory drugs(NSAIDs)in rheumatoid arthritis patients
/ J Kor Soc Hosp Pharm
15(2)
: 186~192
[journal]
Hultqvist M
/ 2009
/ The protective role of ROS in autoimmune disease
/ Trends Immunol
30(5)
: 201~208
[journal]
Dang PM
/ 2001
/ Assembly of the neutrophil respiratory burst oxidase : A direct interaction between p67phox and cytochrome b558
/ Proc Natl Acad Sci USA
98(6)
: 3001~3005
[journal]
Radermacher KA
/ 2012
/ The 1027th target candidate in stroke: Will NADPH oxidase hold up?
/ Exp Transl Stroke Med
4(1)
: 1~11
[journal]
Van Raamsdonk JM
/ 2012
/ Superoxide dismutase is dispensable for normal animal lifespan
/ Proc Natl Acad Sci USA
109(15)
: 5785~5790
[journal]
Preiser JC
/ 2012
/ Oxidative stress
/ JPEN J Parenter Enteral Nutr
36(2)
: 147~154
[journal]
Rotruck JT
/ 1973
/ Selenium : biochemical role as a component of glutathione peroxidase
/ Science
179(4073)
: 588~590
[journal]
박수현
/ 2014
/
Effects of Silibinin and Resveratrol on Degradation of IκB and Translocation of NF-κB p65 Induced by Tumor Necrosis Factor-α in Cultured Airway Epithelial Cells
/ 약 학 회 지
/ 대한약학회
58(1)
: 1~6
[journal]
Asagiri M
/ 2007
/ The molecular understanding of osteoclast differentiation
/ Bone
40(2)
: 251~264
[journal]
Rodríguez-Carballo E
/ 2016
/ p38 MAPK signaling in osteoblast differentiation
/ Front Cell Dev Biol
4
: 40~
[journal]
Kumar S
/ 2003
/ p38 MAP kinases : key signalling molecules as therapeutic targets for inflammatory diseases
/ Nat Rev Drug Discov
2(9)
: 717~726
[journal]
Vanden Berghe W
/ 1998
/ p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-κBp65 transactivation mediated by tumor necrosis factor
/ J Biol Chem
273(6)
: 3285~3290
[journal]
Saha RN
/ 2007
/ MAPK p38 regulates transcriptional activity of NF-κB in primary human astrocytes via acetylation of p65
/ J Immunol
179(10)
: 7101~7109
[journal]
Brune K
/ 2004
/ Selective cyclooxygenase-2 inhibitors : similarities and differences
/ Scand J Rheumatol
33(1)
: 1~6
[journal]
Abramson SB
/ 2008
/ Osteoarthritis and nitric oxide
/ Osteoarthritis Cartilage
16(2)
: 15~20
[journal]
Sakaguchi Y
/ 2004
/ Effects of selective iNOS inhibition on type II collagen-induced arthritis in mice
/ Life Sci
75(19)
: 2257~2267
[journal]
Smolen JS
/ 2007
/ New therapies for treatment of rheumatoid arthritis
/ Lancet
370(9602)
: 1861~1874
[journal]
Iking-Konert C
/ 2014
/ Interleukin-6 inhibition as a potential therapeutic target in rheumatic diseases
/ Z Rheumatol
73(3)
: 269~276
[journal]
Yao X
/ 2014
/ Targeting interleukin-6 in inflammatory autoimmune diseases and cancers
/ Pharmacol Ther
141(2)
: 125~139
[journal]
Nelson AR
/ 2000
/ Matrix metalloproteinases : biologic activity and clinical implications
/ J Clin Oncol
18(5)
: 1135~1149
[journal]
Lambert E
/ 2004
/ TIMPs as multifacial proteins
/ Crit Rev Oncol Hematol
49(3)
: 187~198
[journal]
이수호
/ 2004
/
Acetabular Degeneration in Osteonecrosis of the Femoral Head
/ 대한정형외과학회지
/ 대한정형외과학회
39(3)
: 239~246
[journal]
Dijkgraaf LC
/ 1995
/ Normal cartilage structure, biochemistry, and metabolism : a review of the literature
/ J Oral Maxillofac Surg
53(8)
: 924~929