@article{ART002580653},
author={Chang-Yoon Woo and Kim Youngjun and Chang-Hoon Woo},
title={Antioxidative, Anti-inflammatory Effects of Jibaekjihwang-tang (zhibaidihuang-tang) on Osteoarthritic Rat Model},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2020},
volume={30},
number={2},
pages={1-18},
doi={10.18325/jkmr.2020.30.2.1}
TY - JOUR
AU - Chang-Yoon Woo
AU - Kim Youngjun
AU - Chang-Hoon Woo
TI - Antioxidative, Anti-inflammatory Effects of Jibaekjihwang-tang (zhibaidihuang-tang) on Osteoarthritic Rat Model
JO - Journal of Korean Medicine Rehabilitation
PY - 2020
VL - 30
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 1
EP - 18
SN - 1229-1854
AB - Objectives This study intended to evaluate antioxidative, anti-inflammatory effects of Jibaekjihwang-tang on monosodium iodoacetate (MIA)-induced osteoarthritic rat model and investigate the potential mechanism.
Methods Jibaekjihwang-tang (100 or 200 ㎎/㎏ body weight) was orally administered once daily for 2 weeks days from day 7 after intra-articular MIA injection. And blood analysis, the histologic examinations were performed. Moreover, protein expressions related to anti-oxidant and cartilage degradation and anti-inflammatory cytokines were measured by western blot analysis in cartilaginous tissue.
Results Jibaekjihwang-tang reduced serum inflammatory cytokines such as tumor necosis factors-α and interleukin-6. Furthermore, the increase of anti-oxidant enzymes reversed the oxidative stress caused by MIA. Meanwhile, Jibaekjihwang-tang suppressed MIA-induced inflammation and cartilage degradation in cartilaginous tissue.
Conclusions Jibaekjihwang-tang alleviated MIA-induced inflammation. Jibaekjihwang-tang was associated with a protective effect on cartilage and by reducing inflammation and cartilage degradation. These findings provide new approaches for understanding osteoarthritis therapy. (J Korean Med Rehabil 2020;30(2):1-18)
KW - Iodoacetic acid;Osteoarthritis;Jibaekjihwang-tang;Anti-inflammatory agents;Antioxidants
DO - 10.18325/jkmr.2020.30.2.1
ER -
Chang-Yoon Woo, Kim Youngjun and Chang-Hoon Woo. (2020). Antioxidative, Anti-inflammatory Effects of Jibaekjihwang-tang (zhibaidihuang-tang) on Osteoarthritic Rat Model. Journal of Korean Medicine Rehabilitation, 30(2), 1-18.
Chang-Yoon Woo, Kim Youngjun and Chang-Hoon Woo. 2020, "Antioxidative, Anti-inflammatory Effects of Jibaekjihwang-tang (zhibaidihuang-tang) on Osteoarthritic Rat Model", Journal of Korean Medicine Rehabilitation, vol.30, no.2 pp.1-18. Available from: doi:10.18325/jkmr.2020.30.2.1
Chang-Yoon Woo, Kim Youngjun, Chang-Hoon Woo "Antioxidative, Anti-inflammatory Effects of Jibaekjihwang-tang (zhibaidihuang-tang) on Osteoarthritic Rat Model" Journal of Korean Medicine Rehabilitation 30.2 pp.1-18 (2020) : 1.
Chang-Yoon Woo, Kim Youngjun, Chang-Hoon Woo. Antioxidative, Anti-inflammatory Effects of Jibaekjihwang-tang (zhibaidihuang-tang) on Osteoarthritic Rat Model. 2020; 30(2), 1-18. Available from: doi:10.18325/jkmr.2020.30.2.1
Chang-Yoon Woo, Kim Youngjun and Chang-Hoon Woo. "Antioxidative, Anti-inflammatory Effects of Jibaekjihwang-tang (zhibaidihuang-tang) on Osteoarthritic Rat Model" Journal of Korean Medicine Rehabilitation 30, no.2 (2020) : 1-18.doi: 10.18325/jkmr.2020.30.2.1
Chang-Yoon Woo; Kim Youngjun; Chang-Hoon Woo. Antioxidative, Anti-inflammatory Effects of Jibaekjihwang-tang (zhibaidihuang-tang) on Osteoarthritic Rat Model. Journal of Korean Medicine Rehabilitation, 30(2), 1-18. doi: 10.18325/jkmr.2020.30.2.1
Chang-Yoon Woo; Kim Youngjun; Chang-Hoon Woo. Antioxidative, Anti-inflammatory Effects of Jibaekjihwang-tang (zhibaidihuang-tang) on Osteoarthritic Rat Model. Journal of Korean Medicine Rehabilitation. 2020; 30(2) 1-18. doi: 10.18325/jkmr.2020.30.2.1
Chang-Yoon Woo, Kim Youngjun, Chang-Hoon Woo. Antioxidative, Anti-inflammatory Effects of Jibaekjihwang-tang (zhibaidihuang-tang) on Osteoarthritic Rat Model. 2020; 30(2), 1-18. Available from: doi:10.18325/jkmr.2020.30.2.1
Chang-Yoon Woo, Kim Youngjun and Chang-Hoon Woo. "Antioxidative, Anti-inflammatory Effects of Jibaekjihwang-tang (zhibaidihuang-tang) on Osteoarthritic Rat Model" Journal of Korean Medicine Rehabilitation 30, no.2 (2020) : 1-18.doi: 10.18325/jkmr.2020.30.2.1