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Antioxidative, Anti-inflammatory Effects of Jibaekjihwang-tang (zhibaidihuang-tang) on Osteoarthritic Rat Model

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2020, 30(2), pp.1-18
  • DOI : 10.18325/jkmr.2020.30.2.1
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Received : March 17, 2020
  • Accepted : April 6, 2020
  • Published : April 30, 2020

Chang-Yoon Woo 1 Kim Youngjun ORD ID 2 Chang-Hoon Woo 1

1대구한의대학교
2대구한의대학교 한의과대학 한방재활의학과교실

Accredited

ABSTRACT

Objectives This study intended to evaluate antioxidative, anti-inflammatory effects of Jibaekjihwang-tang on monosodium iodoacetate (MIA)-induced osteoarthritic rat model and investigate the potential mechanism. Methods Jibaekjihwang-tang (100 or 200 ㎎/㎏ body weight) was orally administered once daily for 2 weeks days from day 7 after intra-articular MIA injection. And blood analysis, the histologic examinations were performed. Moreover, protein expressions related to anti-oxidant and cartilage degradation and anti-inflammatory cytokines were measured by western blot analysis in cartilaginous tissue. Results Jibaekjihwang-tang reduced serum inflammatory cytokines such as tumor necosis factors-α and interleukin-6. Furthermore, the increase of anti-oxidant enzymes reversed the oxidative stress caused by MIA. Meanwhile, Jibaekjihwang-tang suppressed MIA-induced inflammation and cartilage degradation in cartilaginous tissue. Conclusions Jibaekjihwang-tang alleviated MIA-induced inflammation. Jibaekjihwang-tang was associated with a protective effect on cartilage and by reducing inflammation and cartilage degradation. These findings provide new approaches for understanding osteoarthritis therapy. (J Korean Med Rehabil 2020;30(2):1-18)

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