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The Effects of ChondroT on Thrombus in FeCl3-induced Rats

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2020, 30(3), pp.45-56
  • DOI : 10.18325/jkmr.2020.30.3.45
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Received : June 11, 2020
  • Accepted : June 26, 2020
  • Published : July 31, 2020

Ji Hoon Kim 1 Sun Gil Kim 1 Joo Il Kim 1 Chan Suk Yoon 1 Ji Min Choi 1 Na Changsu ORD ID 2 Kim Seon Jong 1

1동신대학교 한의과대학 한방재활의학과교실
2동신대학교 한의과대학 경락경혈학회

Accredited

ABSTRACT

Objectives This study was designed to investigate the effects of ChondroT on thrombus in FeCl3-induced rats. Methods We exposed FeCl3 to rat’s carotid artery to induce thrombus. Specimens were divided in 5 groups; Intact, Control, ASA10 (aspirin 10 mg/kg), CT100 (ChondroT 100 mg/kg), and CT200 (ChondroT 200 mg/kg), each n=6. We investigated thromboxane, platelet activating factor (PAF), histological change, lipid metabolism, transaminase, leukocyte, erythrocyte and thrombocyte level. Results In ASA10, CT200 groups, there was significants decrease in both thromboxane level and total cholesterol level, compared to control group and there were significant histological changes of blood vessel, compared to control group. In CT200 group, there was significant decrease in PAF level, compared to control group (p<0.05). In ASA10, CT200 groups, triglycerides level tended to decrease, compared to control group. Conclusions Based on these results, it could be suggested that ChondroT was effective on thrombus in FeCl3-induced rats, and further study is needed to conduct a rigorous clinical research. (J Korean Med Rehabil 2020;30(3):45-56)

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