The Effects of ChondroT on Thrombus in FeCl3-induced Rats (ChondroT 투여가 FeCl3로 유발된 혈전에 미치는 영향)

Ji Hoon Kim (김지훈); Sun Gil Kim (김선길); Joo Il Kim (김주일); Chan Suk Yoon (윤찬석); Ji Min Choi (최지민); Na Changsu (나창수); Kim Seon Jong (김선종)

doi:10.18325/jkmr.2020.30.3.45

The Effects of ChondroT on Thrombus in FeCl3-induced Rats

Journal of Korean Medicine Rehabilitation
Abbr : JKMR
2020, 30(3), pp.45-56
DOI : 10.18325/jkmr.2020.30.3.45
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Medicine and Pharmacy > Korean Medicine
Received : June 11, 2020
Accepted : June 26, 2020
Published : July 31, 2020

Ji Hoon Kim ¹, Sun Gil Kim ¹, Joo Il Kim ¹, Chan Suk Yoon ¹, Ji Min Choi ¹, Na Changsu ², Kim Seon Jong ¹

¹동신대학교 한의과대학 한방재활의학과교실
²동신대학교 한의과대학 경락경혈학회

Accredited

ABSTRACT

Objectives This study was designed to investigate the effects of ChondroT on thrombus in FeCl3-induced rats. Methods We exposed FeCl3 to rat’s carotid artery to induce thrombus. Specimens were divided in 5 groups; Intact, Control, ASA10 (aspirin 10 mg/kg), CT100 (ChondroT 100 mg/kg), and CT200 (ChondroT 200 mg/kg), each n=6. We investigated thromboxane, platelet activating factor (PAF), histological change, lipid metabolism, transaminase, leukocyte, erythrocyte and thrombocyte level. Results In ASA10, CT200 groups, there was significants decrease in both thromboxane level and total cholesterol level, compared to control group and there were significant histological changes of blood vessel, compared to control group. In CT200 group, there was significant decrease in PAF level, compared to control group (p<0.05). In ASA10, CT200 groups, triglycerides level tended to decrease, compared to control group. Conclusions Based on these results, it could be suggested that ChondroT was effective on thrombus in FeCl3-induced rats, and further study is needed to conduct a rigorous clinical research. (J Korean Med Rehabil 2020;30(3):45-56)

KEYWORDS

ChondroT, Thrombosis, Herbal medicine, FeCl3

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The Effects of ChondroT on Thrombus in FeCl3-induced Rats

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The Effects of ChondroT on Thrombus in FeCl3-induced Rats

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