@article{ART002611853},
author={Joo-Il Kim and Sun-Gil Kim and Ji-Hoon Kim and Chan-Suk Yoon and Ji-Min Choi and Chan-Hun Choi and Kim Seon Jong},
title={The Inhibitory Effect of ChondroT on Indomethacin-Induced Gastric Mucosal Injury in Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2020},
volume={30},
number={3},
pages={57-69},
doi={10.18325/jkmr.2020.30.3.57}
TY - JOUR
AU - Joo-Il Kim
AU - Sun-Gil Kim
AU - Ji-Hoon Kim
AU - Chan-Suk Yoon
AU - Ji-Min Choi
AU - Chan-Hun Choi
AU - Kim Seon Jong
TI - The Inhibitory Effect of ChondroT on Indomethacin-Induced Gastric Mucosal Injury in Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2020
VL - 30
IS - 3
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 57
EP - 69
SN - 1229-1854
AB - Objectives The aim of this study was to investigate the inhibitory effect of ChondroT in indomethacin-induced gastric mucosal injury rat model.
Methods Sprague-Dawley rats were randomly assigned to intact, control Joins, Celebrex, ChondroT50 and ChondroT200. Indomethacin (25 mg/kg) was used to induce damage to the gastric mucosal injury. ChondroT was administered by orally to inhibit the indomethacin-induced gastric mucosal injury. At the end of the experiment, pH level in stomach, stomach contents volume, tumor necrosis factor-α (TNF-α) level, interleukin-1β (IL-1β) level, prostaglandin E2 (PGE2) level, myeloperoxidase (MPO) activity, erythrocytes, and thrombocytes were measured. Ophthalmologic and histopathological examination was also analyzed.
Results pH level in stomach and Stomach contents volume had no difference between Control, PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group. TNF-α level was decreased in PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group and there were no significant difference. IL-1β level was decreased in PC-Joins group and ChondroT200 group compared to control group. PGE2 level had no significant difference between Control, PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group. MPO level and complete blood count level were decreased in PC-Joins, PC-Cele, ChondroT50 and ChondroT200. Symptom score of ophthalmologic examination was decreased in ChondroT50 and ChondroT200 group compared to control group.
Conclusion Based on these results, It could be suggested that ChondroT was effective in reducing damage to the gastric mucosal injury. And further study is needed to conduct a rigorous clinical research. (J Korean Med Rehabil 2020;30(3):57-69)
KW - ChondroT;Osteoarthritis;Gastric disease;Indomethacin
DO - 10.18325/jkmr.2020.30.3.57
ER -
Joo-Il Kim, Sun-Gil Kim, Ji-Hoon Kim, Chan-Suk Yoon, Ji-Min Choi, Chan-Hun Choi and Kim Seon Jong. (2020). The Inhibitory Effect of ChondroT on Indomethacin-Induced Gastric Mucosal Injury in Rats. Journal of Korean Medicine Rehabilitation, 30(3), 57-69.
Joo-Il Kim, Sun-Gil Kim, Ji-Hoon Kim, Chan-Suk Yoon, Ji-Min Choi, Chan-Hun Choi and Kim Seon Jong. 2020, "The Inhibitory Effect of ChondroT on Indomethacin-Induced Gastric Mucosal Injury in Rats", Journal of Korean Medicine Rehabilitation, vol.30, no.3 pp.57-69. Available from: doi:10.18325/jkmr.2020.30.3.57
Joo-Il Kim, Sun-Gil Kim, Ji-Hoon Kim, Chan-Suk Yoon, Ji-Min Choi, Chan-Hun Choi, Kim Seon Jong "The Inhibitory Effect of ChondroT on Indomethacin-Induced Gastric Mucosal Injury in Rats" Journal of Korean Medicine Rehabilitation 30.3 pp.57-69 (2020) : 57.
Joo-Il Kim, Sun-Gil Kim, Ji-Hoon Kim, Chan-Suk Yoon, Ji-Min Choi, Chan-Hun Choi, Kim Seon Jong. The Inhibitory Effect of ChondroT on Indomethacin-Induced Gastric Mucosal Injury in Rats. 2020; 30(3), 57-69. Available from: doi:10.18325/jkmr.2020.30.3.57
Joo-Il Kim, Sun-Gil Kim, Ji-Hoon Kim, Chan-Suk Yoon, Ji-Min Choi, Chan-Hun Choi and Kim Seon Jong. "The Inhibitory Effect of ChondroT on Indomethacin-Induced Gastric Mucosal Injury in Rats" Journal of Korean Medicine Rehabilitation 30, no.3 (2020) : 57-69.doi: 10.18325/jkmr.2020.30.3.57
Joo-Il Kim; Sun-Gil Kim; Ji-Hoon Kim; Chan-Suk Yoon; Ji-Min Choi; Chan-Hun Choi; Kim Seon Jong. The Inhibitory Effect of ChondroT on Indomethacin-Induced Gastric Mucosal Injury in Rats. Journal of Korean Medicine Rehabilitation, 30(3), 57-69. doi: 10.18325/jkmr.2020.30.3.57
Joo-Il Kim; Sun-Gil Kim; Ji-Hoon Kim; Chan-Suk Yoon; Ji-Min Choi; Chan-Hun Choi; Kim Seon Jong. The Inhibitory Effect of ChondroT on Indomethacin-Induced Gastric Mucosal Injury in Rats. Journal of Korean Medicine Rehabilitation. 2020; 30(3) 57-69. doi: 10.18325/jkmr.2020.30.3.57
Joo-Il Kim, Sun-Gil Kim, Ji-Hoon Kim, Chan-Suk Yoon, Ji-Min Choi, Chan-Hun Choi, Kim Seon Jong. The Inhibitory Effect of ChondroT on Indomethacin-Induced Gastric Mucosal Injury in Rats. 2020; 30(3), 57-69. Available from: doi:10.18325/jkmr.2020.30.3.57
Joo-Il Kim, Sun-Gil Kim, Ji-Hoon Kim, Chan-Suk Yoon, Ji-Min Choi, Chan-Hun Choi and Kim Seon Jong. "The Inhibitory Effect of ChondroT on Indomethacin-Induced Gastric Mucosal Injury in Rats" Journal of Korean Medicine Rehabilitation 30, no.3 (2020) : 57-69.doi: 10.18325/jkmr.2020.30.3.57