@article{ART002611935},
author={Kyun Hyeong and Je-Hoon Won and Chang-Hoon Woo},
title={Anti-oxidant and Anti-inflammatory Effects of Chulbu-tang},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2020},
volume={30},
number={3},
pages={71-87},
doi={10.18325/jkmr.2020.30.3.71}
TY - JOUR
AU - Kyun Hyeong
AU - Je-Hoon Won
AU - Chang-Hoon Woo
TI - Anti-oxidant and Anti-inflammatory Effects of Chulbu-tang
JO - Journal of Korean Medicine Rehabilitation
PY - 2020
VL - 30
IS - 3
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 71
EP - 87
SN - 1229-1854
AB - Objectives Even though the various alternative herbal medicine has applied for osteoarthritis (OA) treatment, its scientific proof remains uncertain. The aim of the present study evaluates the effects of Chulbu-tang on inflammatory responses in a monosodium iodoacetate (MIA)-induced osteoarthritis rat model.
Methods OA rat model was established by MIA injection in intra-joint of rats. 7 days after, OA rats except OA control rats were administrated Chulbu-tang (100 or 200 mg/kg) or Indomathacin (5 mg/kg) once a day for 14 days. The weight-bearing ability of hind paws were measured when group isolation 0, 7, and 14 days. Western blotting was performed to examine the knockdown/overexpressing efficiency of Chulbu-tang. In addition, cartilage destruction was measured histologically.
Results Chulbu-tang treatment significantly reduced the protein expressions of inflammatory mediators such as inducible nitric oxide synthase and cyclooxygenase 2, and inhibited inflammatory cytokines including tumor necrosis factor alpha, interleukin (IL)-1β, and IL-6 through nuclear factor-kappa B (NF-κB) inactivation. Moreover, anti-oxidant enzymes such as superoxide dismutase and glutathione peroxidase-1/2 through nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway significantly increased. Our findings indicate that Chulbu-tang has the potential therapeutic effect on OA through inhibiting the inflammatory responses via inactivating NF-κB signaling pathway. In addition, upregulation of Nrf2 led to anti-oxidant effects.
Conclusions Taken together, Chulbu-tang is believed to have antioxidant, anti-inflammatory effects, and cartilage protection for arthritis-causing rats. (J Korean Med Rehabil 2020;30(3):71-87)
KW - Iodoacetic acid;Osteoarthritis;Chulbu-tang;Antioxidants;Anti-inflammatory agents
DO - 10.18325/jkmr.2020.30.3.71
ER -
Kyun Hyeong, Je-Hoon Won and Chang-Hoon Woo. (2020). Anti-oxidant and Anti-inflammatory Effects of Chulbu-tang. Journal of Korean Medicine Rehabilitation, 30(3), 71-87.
Kyun Hyeong, Je-Hoon Won and Chang-Hoon Woo. 2020, "Anti-oxidant and Anti-inflammatory Effects of Chulbu-tang", Journal of Korean Medicine Rehabilitation, vol.30, no.3 pp.71-87. Available from: doi:10.18325/jkmr.2020.30.3.71
Kyun Hyeong, Je-Hoon Won, Chang-Hoon Woo "Anti-oxidant and Anti-inflammatory Effects of Chulbu-tang" Journal of Korean Medicine Rehabilitation 30.3 pp.71-87 (2020) : 71.
Kyun Hyeong, Je-Hoon Won, Chang-Hoon Woo. Anti-oxidant and Anti-inflammatory Effects of Chulbu-tang. 2020; 30(3), 71-87. Available from: doi:10.18325/jkmr.2020.30.3.71
Kyun Hyeong, Je-Hoon Won and Chang-Hoon Woo. "Anti-oxidant and Anti-inflammatory Effects of Chulbu-tang" Journal of Korean Medicine Rehabilitation 30, no.3 (2020) : 71-87.doi: 10.18325/jkmr.2020.30.3.71
Kyun Hyeong; Je-Hoon Won; Chang-Hoon Woo. Anti-oxidant and Anti-inflammatory Effects of Chulbu-tang. Journal of Korean Medicine Rehabilitation, 30(3), 71-87. doi: 10.18325/jkmr.2020.30.3.71
Kyun Hyeong; Je-Hoon Won; Chang-Hoon Woo. Anti-oxidant and Anti-inflammatory Effects of Chulbu-tang. Journal of Korean Medicine Rehabilitation. 2020; 30(3) 71-87. doi: 10.18325/jkmr.2020.30.3.71
Kyun Hyeong, Je-Hoon Won, Chang-Hoon Woo. Anti-oxidant and Anti-inflammatory Effects of Chulbu-tang. 2020; 30(3), 71-87. Available from: doi:10.18325/jkmr.2020.30.3.71
Kyun Hyeong, Je-Hoon Won and Chang-Hoon Woo. "Anti-oxidant and Anti-inflammatory Effects of Chulbu-tang" Journal of Korean Medicine Rehabilitation 30, no.3 (2020) : 71-87.doi: 10.18325/jkmr.2020.30.3.71
