Impact of GNB3, ADRB3, UCP2, and PPARγ-Pro12Ala polymorphisms on Boiogito response in obese subjects : A randomized, double-blind, placebo-controlled trial (방기황기탕의 유전자 다형성에 따른 비만 치료 효과 : 무작위 배정, 이중 맹검, 위약-대조군 임상시험)

박정현; BOSE; Lim, Chi-Yeon (임지연); Hojun Kim (김호준)

Impact of GNB3, ADRB3, UCP2, and PPARγ-Pro12Ala polymorphisms on Boiogito response in obese subjects : A randomized, double-blind, placebo-controlled trial

Journal of Korean Medicine for Obesity Research
Abbr : J Korean Med Obes Res
2012, 12(2), pp.28-43
Publisher : The Society of Korean Medicine for Obesity Research
Research Area : Medicine and Pharmacy > Korean Medicine

박정현 ¹, BOSE ², Lim, Chi-Yeon ³, Hojun Kim ⁴

¹강남경희 한방병원 한방재활의학과
²동국대학교의학과 연구실
³동국대학교 의학대학원
⁴동국대학교 한방재활의학과

ABSTRACT

ObjectivesThe aim of the study was to investigate the efficacy of Boiogito for obesity. We examined the efficacy of boiogito for obese patients and we expected the reaction of Boiogito would vary according to the single uncleotide polymorphism(SNPs). Methods111 subjects(body mass index≥25m/kg²) were recruited and randomized to receive Boiogito(n=55) or Placebo(n=55) for 8weeks. Anthropometric factors, serum lipid profile, glucose, blood pressure(BP), pulse rate, resting metabolic rate and Koran version of obesity-related quality of life(KOQOL) scale measured at baseline and 8weeks. SNPs(ß3-adrenegic receptor(ADRB3), G protein ß3(GNB3), peroxisome proliferator activated receptor gamma 2 gene(PPAR-ɤ2), uncoupling protein(UCP2)) were conducted at baseline. Adverse reactions and safety outcome variables were also checked during trials. ResultsBoth groups showed significant improvement on obesity after treatment. Boiogito group decreased triglyceride then did control group and improved KOQOL. Boiogito showed a significant higher efficacy in C/T and T/T genotype of GNB3 gene / in Trp64 and Arg64 genotype of ADRB3 gene / in D/D genotype of UCP2 gene / in Pro/Pro genotype of PPAR-γ gene. ConclusionsBoiogito promoted obesity indexes without severe adverse reactions and proved its safety. Pharmacogenetical studies of Boiogito on obesity could be a effective method for the individualized treatment and prevention of obesity.

KEYWORDS

Boiogito, obesity, SNPs, RCT

Citation status

* References for papers published after 2023 are currently being built.

[journal] Koeppen-Schomerus G / 2001 / A genetic analysis of weight and overweight in 4-year-old twin pairs / Int J Obes Relat Metab Disord 25(6) : 838~844

[journal] Yang W / 2007 / Genetic epidemiology of obesity / Epidemiol Rev 29 : 49~61

[journal] SH, Beck / 2009 / Obesity related gene variations: PPAR-Υ, UCP, β3AR, calpain 10 / Kor J Obes 13(4) : 34~

[journal] Jose, A. M. / 2008 / The PPAR trio: Regulators of myocardial energy metabolism in health and disease / J. Molecular and Cellular Cardio 44 : 968~975

[journal] Hsiao DJ / 2009 / Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene / Pharmacogenet Genomics 19(9) : 730~733

[journal] Beom-Joon Lee / 2007 / The Anti-obesity Effects of Gambi-hwan Extract on Obese Rats Induced by High-fat Diet through the Expression of UCP-1 and PPARδ / 대한한의학회지 / 대한한의학회 28(4) : 136~147

[journal] WJ Shim / 2006 / The effects of UCP-2, 3 polymorphisms on weight loss among Korean overweight women / Kor J Orient Med 6(2) : 59~73

[journal] 장인진 / 2007 / Introduction to Dlinical Pharmacogenetics / Translational and Clinical Pharmacology / 대한임상약리학회 15(1) : 5~19

[journal] 박정현 / 2011 / Efficacy and Adverse Events of Bangpungtongseong-san (Bofutsusho-san ) and Bangkihwangki-tang(Boiogiot-tang ) by Oriental Obesity Pattern Identification on Obese Subjects: Randomized, Double Blind, Placebo-controlled Trial / 한방재활의학과학회지 / 한방재활의학과학회 21(2) : 265~278

[journal] SM Kim / 1998 / What is the best simple anthropometric indexes of abdominal visceral fat in obese patients? / Kor. J. Obes 7(2) : 157~168

[journal] Lahiri DK / 1991 / A rapid non-enzymatic method for the preparation of HMW DNA from blood for RELP studies / Nucleic Acids Res 19(19) : 544~

[journal] YS Song / 1991 / Effects of Bangkihwangki-tang, Bangkihwangki-tang with Lycii fructus and Lycii fructus on the weight of obese rats / J Wonkwang Oriet Med 1(1) : 25~43

[journal] JL Lee / 2001 / The clinical study about the effect of Bangkihwangki -tang / J Orient Rehab Med 11(1) : 297~315

[journal] Shimada T / 2009 / Preventive Effect of Boiogito on Metabolic Disorders in the TSOD Mouse, a Model of Spontaneous Obese Type II Diabetes Mellitus / Evid Based Complement Altemat Med : 1~8

[journal] Noguchi J / 2004 / Efficacy of Boi-ogito for ethical use for osteoarthritis of the knee with joint fluid / Seikei Saigai Geka 47 : 999~1005

[journal] Takahama M / 1995 / Efficacy of Boi-ogi-to in the treatment of rheumatoid arthritis / Nihon Toyo Igaku Zasshi 45(3) : 569~574

[journal] Takeia H / 2007 / The herbal medicines Saireito and Boiogito improve the hypertension of pre-eclamptic rats induced by Nx-Nitro-L-arginine methyl ester / Phytomedicine 14 : 591~600

[journal] Beige J / 1999 / G-Protein beta3 subunit C825T variant and ambulatory blood pressure in essential hypertension / Hypertension 33(4) : 1049~1051

[journal] Hengstenberg C / 2001 / Association between a polymorphism in the G protein beta3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction / Cardiovasc Res 49(4) : 820~827

[journal] Siffert W / 1999 / A significant association of the 825T allele with an increased body mass index(BMI) has been observed in Germans, Chinese, and black Africans: Worldwide ethnic distribution of the G protein β3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and black African individuals / J Am Soc Nephrol 10 : 1921~1931

[journal] Ishikawa K / 2000 / Total cholesterol is significantly higher in subjects with the T allele among Japanese : Human G-protein β3 subunit variant is associated with serum potassium and total cholesterol levels but not with blood pressure / Am J Hypertens 13 : 140~145

[journal] Arner P / 1999 / Adrenoceptor genes in human obesity / J. Intern. Med 245 : 667~672

[journal] BJ Kimz / 1998 / The significance of the β3 adrenergic receptor gene polymorphism in obese Korean / Diabet. Met. J 22(4) : 450~456

[journal] Yoshida T / 1995 / Mutation of beta 3-adrenergic receptor gene and response to treatment of obesity / Lancet 346 : 1433~1434

[journal] Shiwaku K / 2003 / Difficulty in losing weight by behaviral intervention for women with Trp64Arg polymorphism of the beta3-adrenergic receptor gene / Int. J. Obes. Relat. Metab. Disord 27 : 1028~1036

[journal] Sakane N / 1997 / Effect of Trp64Arg64 mutation in the beta 3adrenergic receptor gene on weight loss, body fat distrubution, glycemic control, and insulin resistance in obese type 2 diabetic patients / Diabetes Care 20 : 1987~1990

[journal] Dalgarrd LT / 2001 / Uncoupling proteins : functional characteristics and role in the pathogenesis of obesity and type II diabetes / Diabetologia 44 : 946~965

[journal] SM Lee / 2008 / Study of cardiopulmonary capacity, blood profie and hsCRP according to UCP 2 I/D in the middle aged female / J. Sport Lei Stu 34 : 861~869

[journal] Buemann B / 2001 / The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency / Int J Obes Relat Metab Disord 25(4) : 467~471

[journal] Groemping Y / 2005 / Activation and assembly of the NADPH oxidase : A structural perspective / Biochem J 386 : 401~416

[journal] Tonjes A / 2007 / The role of the Prol2Ala polymorphism in peroxisome proliferator-activated receptor in diabetes risk / Curr. Opin. Clin. Nutr. Metab. Care 10 : 410~414

[journal] Masugi J / 2000 / Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferatoractivated receptor-gamma 2 on thiazolidinedione-induced adipogenesis / Biochem. Biophys. Res. Commun 268 : 178~182

[journal] 박정현 / 2012 / Clinical practice recommendations for Bangpungtongseong-san (Bofutsusho-san) and Bangkihwangki-tang(Boiogito) in obesity / 한방비만학회지 / 한방비만학회 12(1) : 48~58

KJCKorea
Journal Central

Journal of Korean Medicine for Obesity Research 2023 KCI Impact Factor : 0.43