@article{ART002364541},
author={Min-Jee Kim and Myeong-Jong Lee and Hojun Kim},
title={Repeated Dose 90-Day Oral Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats},
journal={Journal of Korean Medicine for Obesity Research},
issn={1976-9334},
year={2018},
volume={18},
number={1},
pages={36-49},
doi={10.15429/jkomor.2018.18.1.36}
TY - JOUR
AU - Min-Jee Kim
AU - Myeong-Jong Lee
AU - Hojun Kim
TI - Repeated Dose 90-Day Oral Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats
JO - Journal of Korean Medicine for Obesity Research
PY - 2018
VL - 18
IS - 1
PB - The Society of Korean Medicine for Obesity Research
SP - 36
EP - 49
SN - 1976-9334
AB - Objectives: The study is aimed at evaluating the possible toxicity in 90-day repeated oral administration of modified Samjung-hwan (mSJH) in Sprague-Dawley (SD) rats. This study was conducted to detect the no-observed adverse effect level (NOAEL).
Methods: Modified SJH extract was administered orally in male and female SD rats at dose of 0, 1,000, 2,000, 4,000 mg/kg. Each group consisted of 10 rats of each gender. The modified SJH extract was given once a day for 90 days. We monitored the changes of mortalities, clinical signs, body weight changes, food consumption, ophthalmologic findings, urine analysis, hematology, serum biochemistry, necropsy findings, organ weights, histological markers of all animals treated with modified SJH extract during the study period.
Results: There were no toxicologically significant changes in mortalities, clinical signs, body weight gains, food consumption, ophthalmologic findings, urine analysis, hematology, serum biochemistry, necropsy findings, organ weights, histological markers in any of rats tested.
Conclusions: The NOAEL of the modified SJH extract in male rats and no observed effect level (NOEL) in female rats are considered 4,000 mg/kg.
KW - No-observed-adverse-effect Level;Safety;Toxicity tests
DO - 10.15429/jkomor.2018.18.1.36
ER -
Min-Jee Kim, Myeong-Jong Lee and Hojun Kim. (2018). Repeated Dose 90-Day Oral Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats. Journal of Korean Medicine for Obesity Research, 18(1), 36-49.
Min-Jee Kim, Myeong-Jong Lee and Hojun Kim. 2018, "Repeated Dose 90-Day Oral Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats", Journal of Korean Medicine for Obesity Research, vol.18, no.1 pp.36-49. Available from: doi:10.15429/jkomor.2018.18.1.36
Min-Jee Kim, Myeong-Jong Lee, Hojun Kim "Repeated Dose 90-Day Oral Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats" Journal of Korean Medicine for Obesity Research 18.1 pp.36-49 (2018) : 36.
Min-Jee Kim, Myeong-Jong Lee, Hojun Kim. Repeated Dose 90-Day Oral Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats. 2018; 18(1), 36-49. Available from: doi:10.15429/jkomor.2018.18.1.36
Min-Jee Kim, Myeong-Jong Lee and Hojun Kim. "Repeated Dose 90-Day Oral Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats" Journal of Korean Medicine for Obesity Research 18, no.1 (2018) : 36-49.doi: 10.15429/jkomor.2018.18.1.36
Min-Jee Kim; Myeong-Jong Lee; Hojun Kim. Repeated Dose 90-Day Oral Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats. Journal of Korean Medicine for Obesity Research, 18(1), 36-49. doi: 10.15429/jkomor.2018.18.1.36
Min-Jee Kim; Myeong-Jong Lee; Hojun Kim. Repeated Dose 90-Day Oral Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats. Journal of Korean Medicine for Obesity Research. 2018; 18(1) 36-49. doi: 10.15429/jkomor.2018.18.1.36
Min-Jee Kim, Myeong-Jong Lee, Hojun Kim. Repeated Dose 90-Day Oral Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats. 2018; 18(1), 36-49. Available from: doi:10.15429/jkomor.2018.18.1.36
Min-Jee Kim, Myeong-Jong Lee and Hojun Kim. "Repeated Dose 90-Day Oral Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats" Journal of Korean Medicine for Obesity Research 18, no.1 (2018) : 36-49.doi: 10.15429/jkomor.2018.18.1.36
