Effects of Combination Therapy with Anti-Obesity Herbal Medicine Including Ephedra Herba and Lorcaserin in Obese Patients: Two Case Reports (마황이 포함된 한방비만 처방과 Lorcaserin 병용 투여 후 호전된 비만 환자 치험 2예)

Min-Jee Kim (김민지); Choi, Han-Seok (최한석); Hojun Kim (김호준)

doi:10.15429/jkomor.2019.19.1.79

Effects of Combination Therapy with Anti-Obesity Herbal Medicine Including Ephedra Herba and Lorcaserin in Obese Patients: Two Case Reports

Journal of Korean Medicine for Obesity Research
Abbr : J Korean Med Obes Res
2019, 19(1), pp.79-87
DOI : 10.15429/jkomor.2019.19.1.79
Publisher : The Society of Korean Medicine for Obesity Research
Research Area : Medicine and Pharmacy > Korean Medicine
Received : May 19, 2019
Accepted : June 3, 2019
Published : June 30, 2019

Min-Jee Kim ¹, Choi, Han-Seok ², Hojun Kim ¹

¹동국대학교 한의과대학 한방재활의학교실
²동국대학교 의과대학 내분비내과학교실

Accredited

ABSTRACT

Although there has been many studies about the co-administration of herb formula and western medicine, there is none about obesity. The aim of this study was to report the effects of co-administration of herb formula containing ephedra sinica and lorcaserin on two obese patients for about 2~4 months. During the treatment, we checked body weight and body composition, and collected blood samples to evaluate liver, kidney, thyroid function and lipid profile. This treatment not only decreased body weight but also improved body composition and lipid profile in both patients. There was no hepatic or renal toxicity, nor any serious side effects of treatment. This study demonstrated that co-administration of herb formula containing ephedra sinica and lorcaserin is a safe and effective therapy to lose weight and improve metabolic parameters for obese patients. Further large-scale clinical trials are needed to evaluate the anti-obesity effect of the combination of herbal and western medicines.

KEYWORDS

Obesity, Lorcaserin, Ephedra

Citation status

* References for papers published after 2023 are currently being built.

[web] KNHANES / 2016 / Health behaviors and chronic disease statistics / Korea Centers for Disease Control and Prevention (KCDC) / https://knhanes.cdc.go.kr/knhanes/sub04/sub04_03.do?classType=7

[journal] Bluher M. / 2019 / Obesity: global epidemiology and pathogenesis / Nat Rev Endocrinol 15(5) : 288~298

[journal] Smith SR / 2017 / Coadministration of Lorcaserin and Phentermine for weight management: A 12-week, randomized, pilot safety study / Obesity (Silver Spring) 25(5) : 857~865

[journal] 조가원 / 2017 / Review on the Efficacy and Safety of Mahuang and Ephedrine in the Treatment of Obesity -Focused on RCT- / 대한한의학회지 / 대한한의학회 38(3) : 170~184

[journal] Ogden CL / 2007 / The epidemiology of obesity 132(6) : 2087~2102

[journal] 서미혜 / 2019 / 2018 Korean Society for the Study of Obesity Guideline for the Management of Obesity in Korea / Journal of Obesity & Metabolic Syndrome / 대한비만학회 28(1) : 40~45

[journal] 김민경 / 2018 / Recent Advances in Anti-Obesity Agents / 대한내과학회지 / 대한내과학회 93(6) : 501~508

[journal] Hauptman J / 2000 / Orlistat in the long-term treatment of obesity in primary care settings / Arch Fam Med 9(2) : 160~167

[journal] Caixàs A / 2014 / Naltrexone sustained-release/bupropion sustained-release for the management of obesity: review of the data to date / Drug Des Devel Ther 8 : 1419~1427

[journal] Mehta A / 2017 / Liraglutide for weight management: a critical review of the evidence / Obes Sci Pract 3(1) : 3~14

[journal] Brashier DB / 2014 / Lorcaserin: A novel antiobesity drug / J Pharmacol Pharmacother 5(2) : 175~178

[journal] Bessesen DH / 2018 / Progress and challenges in anti-obesity pharmacotherapy / Lancet Diabetes Endocrinol 6(3) : 237~248

[journal] Cavaliere H / 2001 / Gastrointestinal side effects of orlistat may be prevented by concomitant prescription of natural fibers (psyllium mucilloid) / Int J Obes Relat Metab Disord 25(7) : 1095~1099

[journal] Magkos F / 2004 / Caffeine and ephedrine: physiological, metabolic and performance-enhancing effects / Sports Med 34(13) : 871~889

[journal] White LM / 1997 / Pharmacokinetics and cardioVAScular effects of ma-huang (Ephedra sinica) in normotensive adults / J Clin Pharmacol 37(2) : 116~122

[journal] Shannon JR / 1999 / Acute effect of ephedrine on 24-h energy balance / Clin Sci (Lond) 96(5) : 483~491

[journal] Song YK / 2007 / Clinical application of Ma Huang in the obesity treatment / J Korean Med Obes Res 7(1) : 1~7

[journal] Kim HJ / 2007 / A clinical practice guideline for Ma-huang (Ephedra sinica) prescription in obesity / J Korean Med Obes Res 7(2) : 27~37

KJCKorea
Journal Central

Journal of Korean Medicine for Obesity Research 2023 KCI Impact Factor : 0.43

Effects of Combination Therapy with Anti-Obesity Herbal Medicine Including Ephedra Herba and Lorcaserin in Obese Patients: Two Case Reports

ABSTRACT

KEYWORDS

Citation status

* References for papers published after 2023 are currently being built.

Journal of Korean Medicine for Obesity Research 2023 KCI Impact Factor : 0.43

Effects of Combination Therapy with Anti-Obesity Herbal Medicine Including Ephedra Herba and Lorcaserin in Obese Patients: Two Case Reports

ABSTRACT

KEYWORDS

Statistics

Tools

Issue List

Citation status

KCI Citation Counts (1)

REFERENCES (18) * References for papers published after 2023 are currently being built.

Search PDF

Citation

* References for papers published after 2023 are currently being built.