@article{ART002598740},
author={Sang-Hoon Yoon and Eunji Lee and Hyunjung Jo and Yeji Han and Hyunho Kim and Younghee Yun and Ye-Yong Choi and Jongseung Park and Jungtae Leem},
title={Effect and Safety of Combined Treatment of Gambihwan and Garcinia Cambogia on Weight Loss: A Retrospective Observational Study},
journal={Journal of Korean Medicine for Obesity Research},
issn={1976-9334},
year={2020},
volume={20},
number={1},
pages={31-39},
doi={10.15429/jkomor.2020.20.1.31}
TY - JOUR
AU - Sang-Hoon Yoon
AU - Eunji Lee
AU - Hyunjung Jo
AU - Yeji Han
AU - Hyunho Kim
AU - Younghee Yun
AU - Ye-Yong Choi
AU - Jongseung Park
AU - Jungtae Leem
TI - Effect and Safety of Combined Treatment of Gambihwan and Garcinia Cambogia on Weight Loss: A Retrospective Observational Study
JO - Journal of Korean Medicine for Obesity Research
PY - 2020
VL - 20
IS - 1
PB - The Society of Korean Medicine for Obesity Research
SP - 31
EP - 39
SN - 1976-9334
AB - Objectives: Obesity is becoming more popular disease worldwide. Because of the side effects of conventional obesity treatment modality, herbal medicine treatment is becoming more preferred. Gambihwan which including Ephedra sinica Staph is widely used in traditional Korean Medicine practice for obesity treatment. Garcinia cambogia is a kind of health functional food that has body fat reducing effect. Nowadays, ephedra and Garcinia cambogia are often used simultaneously in clinical practice of Korean Medicine. However, the effectiveness and safety of combination therapy in obesity treatment is not well established.
Methods: We conducted retrospective observational study to explore effectiveness and safety of combination therapy. We evaluated effect of combined treatment of Gambihwan and Garcinia cambogia on body weight, body mass index, body fat mass, and waist hip ratio reduction. We also assessed safety via liver function test and adverse event.
Results: Finally, 23 patients were included. In paired t-test, body weight significantly decreased from 64.50±14.50 kg to 62.94±13.85 kg (P<0.001) and body mass index were also significantly decreased from 24.43±3.79 kg/m2 to 23.83±3.59 kg/m2 (P<0.001). Body fat mass was also reduced. Aspartate transaminase and alanine aminotransferase were not significantly increased. There were no drug-induced liver injury and no severe adverse event.
Conclusions: In our retrospective review, we found combination therapy of Gambihwan and Garcinia cambogia reduce body weight, body mass index and body fat mass. There were no severe adverse event and drug induced liver injury which indicated safety of combination therapy in obesity treatment.
KW - Anti-obesity agents;Garcinia cambogia;Korean traditional medicine;Safety;Ephedrine
DO - 10.15429/jkomor.2020.20.1.31
ER -
Sang-Hoon Yoon, Eunji Lee, Hyunjung Jo, Yeji Han, Hyunho Kim, Younghee Yun, Ye-Yong Choi, Jongseung Park and Jungtae Leem. (2020). Effect and Safety of Combined Treatment of Gambihwan and Garcinia Cambogia on Weight Loss: A Retrospective Observational Study. Journal of Korean Medicine for Obesity Research, 20(1), 31-39.
Sang-Hoon Yoon, Eunji Lee, Hyunjung Jo, Yeji Han, Hyunho Kim, Younghee Yun, Ye-Yong Choi, Jongseung Park and Jungtae Leem. 2020, "Effect and Safety of Combined Treatment of Gambihwan and Garcinia Cambogia on Weight Loss: A Retrospective Observational Study", Journal of Korean Medicine for Obesity Research, vol.20, no.1 pp.31-39. Available from: doi:10.15429/jkomor.2020.20.1.31
Sang-Hoon Yoon, Eunji Lee, Hyunjung Jo, Yeji Han, Hyunho Kim, Younghee Yun, Ye-Yong Choi, Jongseung Park, Jungtae Leem "Effect and Safety of Combined Treatment of Gambihwan and Garcinia Cambogia on Weight Loss: A Retrospective Observational Study" Journal of Korean Medicine for Obesity Research 20.1 pp.31-39 (2020) : 31.
Sang-Hoon Yoon, Eunji Lee, Hyunjung Jo, Yeji Han, Hyunho Kim, Younghee Yun, Ye-Yong Choi, Jongseung Park, Jungtae Leem. Effect and Safety of Combined Treatment of Gambihwan and Garcinia Cambogia on Weight Loss: A Retrospective Observational Study. 2020; 20(1), 31-39. Available from: doi:10.15429/jkomor.2020.20.1.31
Sang-Hoon Yoon, Eunji Lee, Hyunjung Jo, Yeji Han, Hyunho Kim, Younghee Yun, Ye-Yong Choi, Jongseung Park and Jungtae Leem. "Effect and Safety of Combined Treatment of Gambihwan and Garcinia Cambogia on Weight Loss: A Retrospective Observational Study" Journal of Korean Medicine for Obesity Research 20, no.1 (2020) : 31-39.doi: 10.15429/jkomor.2020.20.1.31
Sang-Hoon Yoon; Eunji Lee; Hyunjung Jo; Yeji Han; Hyunho Kim; Younghee Yun; Ye-Yong Choi; Jongseung Park; Jungtae Leem. Effect and Safety of Combined Treatment of Gambihwan and Garcinia Cambogia on Weight Loss: A Retrospective Observational Study. Journal of Korean Medicine for Obesity Research, 20(1), 31-39. doi: 10.15429/jkomor.2020.20.1.31
Sang-Hoon Yoon; Eunji Lee; Hyunjung Jo; Yeji Han; Hyunho Kim; Younghee Yun; Ye-Yong Choi; Jongseung Park; Jungtae Leem. Effect and Safety of Combined Treatment of Gambihwan and Garcinia Cambogia on Weight Loss: A Retrospective Observational Study. Journal of Korean Medicine for Obesity Research. 2020; 20(1) 31-39. doi: 10.15429/jkomor.2020.20.1.31
Sang-Hoon Yoon, Eunji Lee, Hyunjung Jo, Yeji Han, Hyunho Kim, Younghee Yun, Ye-Yong Choi, Jongseung Park, Jungtae Leem. Effect and Safety of Combined Treatment of Gambihwan and Garcinia Cambogia on Weight Loss: A Retrospective Observational Study. 2020; 20(1), 31-39. Available from: doi:10.15429/jkomor.2020.20.1.31
Sang-Hoon Yoon, Eunji Lee, Hyunjung Jo, Yeji Han, Hyunho Kim, Younghee Yun, Ye-Yong Choi, Jongseung Park and Jungtae Leem. "Effect and Safety of Combined Treatment of Gambihwan and Garcinia Cambogia on Weight Loss: A Retrospective Observational Study" Journal of Korean Medicine for Obesity Research 20, no.1 (2020) : 31-39.doi: 10.15429/jkomor.2020.20.1.31
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