The purpose of this study is to examine and understand the stress, anxiety, job stress, burnout, and turnover intention perceived by clinical dental hygienists under pandemic situations caused by viral epidemics, and analyze the interrelationship and related factors influencing the clinical dental hygienists’ turnover intention. An online survey was conducted to measure the extent of stress and anxiety towards the viral epidemics targeting clinical dental hygienists, and 204 clinical dental hygienists serving at dental hospitals and clinics participated. The pearson correlation analysis was performed, and the stepwise multiple regression analysis was performed for the factors influencing the turnover intention. The results of this study demonstrated that the stress and anxiety towards the viral epidemics turned out to be exhausted (r=0.30, p<0.01), job stress (r=0.28, p<0.01), and turnover intention (r=0.19, p<0.01), reflective of a significant positive correlation. The factors influencing the turnover intention were emotional fatigue from burnout (p=0.23, p=0.001), job stress (p=0.48, p<0.001), and bachelor’s degree (p=0.14, p=0.008). The adjusted explanatory power of this model was 44%, respectively. Given the current situation where the COVID-19 epidemic has prolonged, it would be necessary to provide sufficient rest, provide a safe work environment, and apply work stress relief and management program to reduce the turnover rate of the clinical dental hygienists.