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@article{ART002647722},
author={Lee Ji-hye and Kim Hye-jeong and Park Ju-sik and Park Jin-han},
title={Garlic Gongjin-Dan Ameliorates Scopolamine-Induced AMNESIA in Mice},
journal={Kinesiology },
issn={2435-0702},
year={2018},
volume={3},
number={2},
pages={1-9}

TY - JOUR
AU - Lee Ji-hye
AU - Kim Hye-jeong
AU - Park Ju-sik
AU - Park Jin-han
TI - Garlic Gongjin-Dan Ameliorates Scopolamine-Induced AMNESIA in Mice
JO - Kinesiology
PY - 2018
VL - 3
IS - 2
PB - Northeast Asian Studies Journal Institute (J-INSTITUTE)
SP - 1
EP - 9
SN - 2435-0702
AB - Gongjin-Dan is a traditional oriental medicine herbal drug that has been used tonics. In the present study, we investigated the effects of the hot water extract of Gongjin-Dan mixed garlic(GGD) against scopolamine-induced memory impairment and its mechanism of action. We used the Y-maze and passive avoidance tests to assess anti-amnesic activities in scopolamine-induced memory impairment mouse model. In this model, GGD(12.5, 25 or 50 mg/kg) significantly ameliorated scopolamine-induced memory impairment. We also explored its mechanism of action by conducting an antioxidant activity assay using 2,2-diphenyl-1-picrylhydrazyl(DPPH) and 2,2’-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) free and acetylcholineserase(AChE) activity assay using the mouse whole brain. GGD increased the scavenging activities of free radical DPPH and ABTS, inhibited AChE activity in the brain. Taken together, our findings suggest that GGD exerts an anti-amnesic effect through the free radical scavenging, AChE inhibition, ameliorate of scopolamine-induced memory impairment. The effect of GGD may be useful for treatment of memory impairment in Alzheimer’s and its related diseases.
KW - Sport;Garlic Gongjin-Dan;Scopolamine;Memory Impairment;Alzheimer’s Diseases
DO -
UR -
ER -

Lee Ji-hye, Kim Hye-jeong, Park Ju-sik and Park Jin-han. (2018). Garlic Gongjin-Dan Ameliorates Scopolamine-Induced AMNESIA in Mice. Kinesiology , 3(2), 1-9.

Lee Ji-hye, Kim Hye-jeong, Park Ju-sik and Park Jin-han. 2018, "Garlic Gongjin-Dan Ameliorates Scopolamine-Induced AMNESIA in Mice", Kinesiology , vol.3, no.2 pp.1-9.

Lee Ji-hye, Kim Hye-jeong, Park Ju-sik, Park Jin-han "Garlic Gongjin-Dan Ameliorates Scopolamine-Induced AMNESIA in Mice" Kinesiology 3.2 pp.1-9 (2018) : 1.

Lee Ji-hye, Kim Hye-jeong, Park Ju-sik, Park Jin-han. Garlic Gongjin-Dan Ameliorates Scopolamine-Induced AMNESIA in Mice. 2018; 3(2), 1-9.

Lee Ji-hye, Kim Hye-jeong, Park Ju-sik and Park Jin-han. "Garlic Gongjin-Dan Ameliorates Scopolamine-Induced AMNESIA in Mice" Kinesiology 3, no.2 (2018) : 1-9.

Lee Ji-hye; Kim Hye-jeong; Park Ju-sik; Park Jin-han. Garlic Gongjin-Dan Ameliorates Scopolamine-Induced AMNESIA in Mice. Kinesiology , 3(2), 1-9.

Lee Ji-hye; Kim Hye-jeong; Park Ju-sik; Park Jin-han. Garlic Gongjin-Dan Ameliorates Scopolamine-Induced AMNESIA in Mice. Kinesiology . 2018; 3(2) 1-9.

Lee Ji-hye, Kim Hye-jeong, Park Ju-sik, Park Jin-han. Garlic Gongjin-Dan Ameliorates Scopolamine-Induced AMNESIA in Mice. 2018; 3(2), 1-9.

Lee Ji-hye, Kim Hye-jeong, Park Ju-sik and Park Jin-han. "Garlic Gongjin-Dan Ameliorates Scopolamine-Induced AMNESIA in Mice" Kinesiology 3, no.2 (2018) : 1-9.