Purpose: The purpose of the study was to explore the levels of quality of life (QoL), post-traumatic growth, resilience, and optimism in disaster victims and to identify factors influencing QoL. Methods: The data were collected from questionnaires of convenience sample of 219 disaster victims in 2013 in Korea. The data were analyzed using descriptive statistics, t-test, ANOVA, Pearson correlation coefficients, and stepwise multiple regression. Results: The mean items score of QoL was 3.1, 2.9 for post-traumatic growth, and 2.1 for optimism (5point) and that of resilience was 2.5 (4point). QoL was significantly different by perceived health status at present, change of health status after disaster. QoL was correlated positively with post-traumatic growth, resilience, optimism. As a result of multiple regression analysis, QoL was accounted for 36.4% of the variance by post-traumatic growth, optimism, recovery rate after disaster, perceived health status at present, recovery rate of health status after disaster, current suffering due to disaster. Optimism was the most important factor for QoL, which explained 18.8% of the variation. Conclusion: The results of the study show that strengthening optimism needs to be integrated in developing effective intervention program for enhancing QoL in disaster victims.