Korean Journal of Occupational Therapy 2023 KCI Impact Factor : 0.81
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pISSN : 1226-0134 / eISSN : 2671-4450
- https://journal.kci.go.kr/kjot
KJCKorea
Journal Central
Combination Pharmacological Interventions for Smoking Cessation and Post-Cessation Weight Gain: A Meta-Analysis of Randomized Controlled Trials
- Korean Journal of Occupational Therapy
- Abbr : Korean J of Occup Ther
- 2020, 28(4), pp.121-135
- DOI : 10.14519/kjot.2020.28.4.10
- Publisher : Korean Society Of Occupational Therapy
- Research Area : Medicine and Pharmacy > Working Therapeutics
- Received : May 27, 2020
- Accepted : July 11, 2020
- Published : December 30, 2020
Gail Castañeda 1, Jaewon Kang 2, Mi Jung Lee 1, Nancy Schaefer 2, Sergio Romero 2
1Veterans Rural Health Resource Center
2University of Florida
Accredited
ABSTRACT
Objective: Limited evidence exists concerning whether combined pharmacotherapy is more effective thanmonotherapy for increased smoking abstinence and post-cessation weight gain prevention. This researchinvestigated the effect of combined pharmacotherapy on smoking abstinence and post-cessation weight change.
Methods: A meta-analytic review of Randomized Controlled Trials (RCTs) published between January 1990 andJuly 2016 was conducted across PubMed, International Pharmaceutical Abstracts, Web of Science, and CochraneLibrary. Aggregate fixed effects were estimated for continuous abstinence and mean post-cessation weightchange. Keyword search terms included: “smoking cessation,” “naltrexone”, “varenicline”, and “bupropion”.
Results: Eight RCTs with 2,513 participants were included. Aggregate fixed effect estimates revealed an increasein continuous smoking abstinence (OR = 1.81, p < .001) and mean decrease in post-cessation weight change(-.15 kg, p = .001). Decreased weight change was observed at 6-8 weeks follow-up (-.14 kg, p = .02).
Increased mean weight change was observed among varenicline plus nicotine patch abstainers (.21 kg, p = .01),whereas bupropion plus NRT pharmacotherapies showed decreased mean weight change (-.15 kg, p = .01).
Conclusion: Combination pharmacotherapy generates increased smoking abstinence and small short-termpost-cessation weight change among abstainers, particularly among bupropion plus NRT when compared againstvarenicline plus nicotine patch.
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[journal]
Alberg, A. J.
/ 2007
/ Weight gain as an impediment to cigarette smoking cessation: A lingering problem in need of solutions
/ Preventive Medicine: An International Journal Devoted to Practice &Theory
44(4)
: 296~297
[journal]
Biberman, R.
/ 2003
/ A randomized controlled trial of oral selegiline plus nicotine skin patch compared with placebo plus nicotine skin patch for smoking cessation
/ Addiction
98(10)
: 1403~1407
[journal]
Bohadana, A.
/ 2000
/ Nicotine inhaler and nicotine patch as a combination therapy for smoking cessation : A randomized, double-blind, placebo-controlled trial
/ Archives of Internal Medicine
160(20)
: 3128~3134
[book]
Borenstein, M.
/ 2009
/ Introduction to Meta-analysis Vol. 77
/ Wiley
: 85~
[book]
Champagne, T.
/ 2016
/ AOTA fact sheet: Occupational therapy’s role in mental health recovery
/ AOTA, Inc
[journal]
최민혁
/ 2016
/
Comparing the smoking rates between people with and without disabilities: Using propensity score matching
/ 보건교육건강증진학회지
/ 한국보건교육건강증진학회
33(1)
: 61~70
[journal]
Clark, M. M.
/ 2006
/ The prevalence of weight concerns in a smoking abstinence clinical trial
/ Addictive Behaviors
31(7)
: 1144~1152
[journal]
Conn, A.
/ 2019
/ Occupational therapy intervention addressing weight gain and obesity in people with severe mental illness : A scoping review
/ Australian Occupational Therapy Journal
66(4)
: 446~457
[journal]
Ebbert, J. O.
/ 2014
/ Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers : A randomized trial
/ JAMA
311(2)
: 155~163
[other]
Fiore, M. C.
/ 2008
/ Treating tobacco use and dependence: 2008 update
/ U.S. Department of Health and Human Services
[journal]
Froom, P.
/ 1998
/ Smoking cessation and weight gain
/ Journal of Family Practice
46(6)
: 460~464
[journal]
Gerace, T. A.
/ 1991
/ Smoking cessation and change in diastolic blood pressure, body weight, and plasma lipids
/ Preventive Medicine
20(5)
: 602~620
[journal]
Gonzales, D.
/ 2006
/ Varenicline, an α4β2nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: A randomized controlled trial
/ JAMA
296(1)
: 47~55
[journal]
Hajek, P.
/ 2013
/ Is a combination of varenicline and nicotine patch more effective in helping smokers quit than varenicline alone? A randomized controlled trial
/ BMC Medicine
11(1)
: 1~7
[journal]
Hays, J. T.
/ 2003
/ Bupropion sustained release for treatment of tobacco dependence
/ Mayo Clinic Proceedings
78(8)
: 1020~1024
[journal]
Healton, C.
/ 2008
/ Treating tobacco use and dependence : 2008 update US public health service clinical practice guideline executive summary
/ Respiratory Care
53(9)
: 1217~1222
[journal]
Jordan, K.
/ 2019
/ A provider-patient relationship : The critical first step of smoking cessation
/ Journal of General Internal Medicine
35
: 10~11
[journal]
Jorenby, D. E.
/ 1999
/ A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation
/ New England Journal of Medicine
340(9)
: 685~691
[journal]
Koegelenberg, C. F.
/ 2014
/ Efficacy of varenicline combined with nicotine replacement therapy vs varenicline alone for smoking cessation : A randomized clinical trial
/ JAMA
312(2)
: 155~161
[web]
Korean Statistical Information Service
/ 2020
/ Korea national health and nutrition examination survey
/ https://kosis.kr/statisticsList/statisticsListIndex.do?menuId=M_01_01&vwcd=MT_ZTITLE&parmTabId=M_01_01&parentId=D.1;D1.2;117_11702.3;#SelectStatsBoxDiv
[journal]
Lycett, D.
/ 2011
/ Associations between weight change over 8 years and baseline body mass index in a cohort of continuing and quitting smokers
/ Addiction
106(1)
: 188~196
[journal]
Nides, M.
/ 2008
/ Varenicline versus bupropion SR or placebo for smoking cessation : A pooled analysis
/ American Journal of Health Behavior
32(6)
: 664~675
[journal]
O’Hara, P.
/ 1998
/ Early and late weight gain following smoking cessation in the lung health study
/ American Journal of Epidemiology
148(9)
: 821~830
[journal]
O’Malley, S. S.
/ 2006
/ A controlled trial of naltrexone augmentation of nicotine replacement therapy for smoking cessation
/ Archives of Internal Medicine
166(6)
: 667~674
[journal]
Piper, M. E.
/ 2007
/ Efficacy of bupropion alone and in combination with nicotine gum
/ Nicotine &Tobacco Research
9(9)
: 947~954
[web]
Statistics Korea
/ 2020
/ Korea national health and nutrition examination survey
/ http://kosis.kr/statHtml/statHtml.do?orgId=117&tblId=DT_11702_N001&conn_path=I2
[journal]
Sterne, J. A.
/ 2000
/ Publication and related bias in meta-analysis : Power of statistical tests and prevalence in the literature
/ Journal of Clinical Epidemiology
53(11)
: 1119~1129
[book]
TEAM-R, R. C.
/ 2016
/ A language and environment for statistical computing
/ R Foundation for Statistical
[report]
U.S. Department of Health and Human Services
/ 2014
/ The health consequences of smoking50 years of progress: A report of the surgeon general
/ U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health
[journal]
Wei, K.
/ 2014
/ Ultrasound-guided stellate ganglion blocks combined with pharmacological and occupational therapy in Complex Regional Pain Syndrome(CRPS) : A pilot case series ad interim
/ Pain Medicine
15(12)
: 2120~2127
[journal]
Williamson, D. F.
/ 1991
/ Smoking cessation and severity of weight gain in a national cohort
/ New England Journal of Medicine
324(11)
: 739~745
[web]
World Health Organization
/ 2019
/ WHO report on the global tobacco epidemic 2019: Offer help to quit tobacco use
/ www.who.int/tobacco
[journal]
Yang, M.
/ 2013
/ Does combination pharmacological intervention for smoking cessation prevent post-cessation weight gain? A systemic review
/ Addictive Behaviors
38(3)
: 1865~1875
[journal]
Yeh, H. C.
/ 2010
/ Smoking, smoking cessation, and risk for type 2 diabetes mellitus : a cohort study
/ Annals of Internal Medicine
152(1)
: 10~17
[journal]
Zhu, S. H.
/ 2002
/ Evidence of realworld effectiveness of a telephone quitline for smokers
/ New England Journal of Medicine
347(14)
: 1087~1093
[journal]
Zintzaras, E.
/ 2005
/ Heterogeneity testing in meta-analysis of genome searches
/ Genetic Epidemiology: The Official Publication of the International Genetic Epidemiology Society
28(2)
: 123~137