Journal of Korean Society of Spine Surgery 2023 KCI Impact Factor : 0.03
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pISSN : 2093-4378 / eISSN : 2093-4386
- https://journal.kci.go.kr/krspine
KJCKorea
Journal Central
Recent Advances in the Pathophysiology and Treatment of Acute Spinal Cord Injury
- Journal of Korean Society of Spine Surgery
- Abbr : J Kor Spine Sur
- 2008, 15(3), pp.204-213
- Publisher : Korean Society Of Spine Surgery
- Research Area : Medicine and Pharmacy > Orthopedic Surgery
1조선대학교
Candidate
ABSTRACT
Study Design: This is a literature review
Objectives: We wanted to provide updated information for spine clinicians on the pathophysiology, medical treatment and the
timing of surgical treatment after acute spinal cord injury.
Summary of the Literature Review: There are many studies concerned with understanding the mechanisms of injury and
improving the neurologic function after acute spinal cord injury. However, methylprednisolone therapy has been used only
recently for the treatment of this malady.
Materials and Methods: We conducted a literature review, with a particular focus on the development of pathophysiology and
the emerging pharmacologic treatment of acute spinal cord injury, and on the effectiveness of performing early decompression.
Results: After primary mechanical impact, a complex cascade of secondary injury follows during acute spinal cord injury. Neuroprotection
and axonal regeneration are the main strategies to treat spinal cord injury. Beyond methylprednisolone, a number
of other pharmacological treatments have been studied for the acute treatment of spinal cord injury. Animal studies support
early decompression of the injured cord. Although there is no standard regarding the timing of decompression, there are many
advantages of performing early decompression in human.
Conclusion: Although a number of pharmacological therapies seem to have neuroprotective potential, high-dose methyprednisolone
therapy is the only clinically approved treatment for acute spinal cord injury. Urgent decompression for acute spinal
cord injury remains a reasonable practice option.
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