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@article{ART001610924},
author={소광영 and Yong-Soo Choi and 윤대현 and 류지훈 and Brian Johnstone and Jung U Yoo},
title={Development of an Intervertebral Disc Degeneration Model using Newzealand White Rabbits},
journal={Journal of Korean Society of Spine Surgery},
issn={2093-4378},
year={2011},
volume={18},
number={4},
pages={179-185}

TY - JOUR
AU - 소광영
AU - Yong-Soo Choi
AU - 윤대현
AU - 류지훈
AU - Brian Johnstone
AU - Jung U Yoo
TI - Development of an Intervertebral Disc Degeneration Model using Newzealand White Rabbits
JO - Journal of Korean Society of Spine Surgery
PY - 2011
VL - 18
IS - 4
PB - Korean Society Of Spine Surgery
SP - 179
EP - 185
SN - 2093-4378
AB - Study Design: An experimental animal study. Objectives: To create a more appropriate disc degeneration model which shows how Interleukin 1α may induce the activation of metalloproteinases within the nucleus pulposus. Summary of Literature Review: There are few disc degeneration models wherein there is activation of metalloproteinases within the nucleus pulposus without structural destruction of the intervertebral disc. Materials and Methods: Three consecutive intervertebral discs in New Zealand White Rabbits were exposed. Each disc was injected with 0.1ml of saline (Saline group), 0.1ml of 1μg/ml (IL-1 group), 0.1ml of 10μg/ml (IL-10 group) of IL-1α through a 30-gauge needle. The lumbar spine was harvested 12 weeks after operation. We then analyzed radiographic findings and histological changes. Results: There was no difference in the radiological disc height index among the three groups; 0.071 in saline group, 0.045 in IL-1 group and 0.058 in IL-10 group (p=0.194). The histological cellularity of the nucleus pulposus revealed a decrease in the number of cells (p=0.0001,1.42 in saline group vs. 3.00 in IL-10 group; p=0.001, 2.00 in IL-1 group and 3.00 in IL-10). The histological matrix of the nucleus pulposus was 1.42 in saline group and 2.42 in IL-10(p=0.007), which meant that there had been condensation of the extracellular nucleus pulposus matrix. Conclusions: The results of this study demonstrate that interleukin-1α may contribute to degradation of the nucleus pulposus. This is useful for future study into the effects of the cytokine inhibitor on matrix regeneration and cellularity in the nucleus pulposus in intervertebral disc disease.
KW - Intervertebral disc;Degeneration model;Interleukin-1α;Rabbit
DO -
UR -
ER -

소광영, Yong-Soo Choi, 윤대현, 류지훈, Brian Johnstone and Jung U Yoo. (2011). Development of an Intervertebral Disc Degeneration Model using Newzealand White Rabbits. Journal of Korean Society of Spine Surgery, 18(4), 179-185.

소광영, Yong-Soo Choi, 윤대현, 류지훈, Brian Johnstone and Jung U Yoo. 2011, "Development of an Intervertebral Disc Degeneration Model using Newzealand White Rabbits", Journal of Korean Society of Spine Surgery, vol.18, no.4 pp.179-185.

소광영, Yong-Soo Choi, 윤대현, 류지훈, Brian Johnstone, Jung U Yoo "Development of an Intervertebral Disc Degeneration Model using Newzealand White Rabbits" Journal of Korean Society of Spine Surgery 18.4 pp.179-185 (2011) : 179.

소광영, Yong-Soo Choi, 윤대현, 류지훈, Brian Johnstone, Jung U Yoo. Development of an Intervertebral Disc Degeneration Model using Newzealand White Rabbits. 2011; 18(4), 179-185.

소광영, Yong-Soo Choi, 윤대현, 류지훈, Brian Johnstone and Jung U Yoo. "Development of an Intervertebral Disc Degeneration Model using Newzealand White Rabbits" Journal of Korean Society of Spine Surgery 18, no.4 (2011) : 179-185.

소광영; Yong-Soo Choi; 윤대현; 류지훈; Brian Johnstone; Jung U Yoo. Development of an Intervertebral Disc Degeneration Model using Newzealand White Rabbits. Journal of Korean Society of Spine Surgery, 18(4), 179-185.

소광영; Yong-Soo Choi; 윤대현; 류지훈; Brian Johnstone; Jung U Yoo. Development of an Intervertebral Disc Degeneration Model using Newzealand White Rabbits. Journal of Korean Society of Spine Surgery. 2011; 18(4) 179-185.

소광영, Yong-Soo Choi, 윤대현, 류지훈, Brian Johnstone, Jung U Yoo. Development of an Intervertebral Disc Degeneration Model using Newzealand White Rabbits. 2011; 18(4), 179-185.

소광영, Yong-Soo Choi, 윤대현, 류지훈, Brian Johnstone and Jung U Yoo. "Development of an Intervertebral Disc Degeneration Model using Newzealand White Rabbits" Journal of Korean Society of Spine Surgery 18, no.4 (2011) : 179-185.