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Clinical Usefulness of Fentanyl Matrix Patch for the Patients with Chronic Low Back Pain

  • Journal of Korean Society of Spine Surgery
  • Abbr : J Kor Spine Sur
  • 2014, 21(4), pp.166-172
  • Publisher : Korean Society Of Spine Surgery
  • Research Area : Medicine and Pharmacy > Orthopedic Surgery

정구영 1 전창훈 2 Chung, Nam-Su 2 서현석 1

1아주대학교병원 정형외과학교실
2아주대학교

Accredited

ABSTRACT

Study Design: Prospective observational study. Objectives: The aim of this study was to examine the usefulness of a fentanyl matrix patch in the management of chronic low back pain. Summary of Literature Review: Chronic low back pain is a significant disabling disease with high medical costs and socioeconomicaleffects. Oral medication is a fundamental tool for conservative treatment. The fentanyl matrix patch is currently regarded as analternative method for oral medication, however, the usefulness of the fentanyl matrix patch has not been fully evaluated. Materials and Methods: From September 2008 to May 2009, a multicenter, open, prospective observational study was conducted. The inclusion criteria included chronic pain patients that did not respond to conservative pain management. The clinical usefulness wasevaluated with pain intensity, and the KEQ-5D (Korean version of Euro QoL-5 dimension). Results: Overall, 538 patients were included in this study. The pain intensity decreased about 1.84 ± 1.91 at the second visit and furtherdecreased by about 2.52 ± 2.34 at the third visit (p<0.0001). The KEQ-5D score decreased about 0.12 ± 0.18 at the second visit, anddecreased further to 0.18 ± 0.24 at the third visit (p<0.0001). The number of patients with adverse effects was 121 (22.49%). Conclusions: The fentanyl matrix patch improves the pain and disability in patients with chronic low back pain. It is a useful alternativemethod for the management of chronic low back pain.

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