Neurophysiologic Mechanism of Pain (통증의 신경생리학적 기전)

라인후; Woo-Kie Min (민우기)

Neurophysiologic Mechanism of Pain

Journal of Korean Society of Spine Surgery
Abbr : J Kor Spine Sur
2015, 22(1), pp.13-19
Publisher : Korean Society Of Spine Surgery
Research Area : Medicine and Pharmacy > Orthopedic Surgery

라인후 ¹, Woo-Kie Min ¹

¹경북대학교

Accredited

ABSTRACT

Study Design: A review of the literature regarding neurophysiologic mechanism of pain. Objectives: To review and discuss neurophysiologic mechanism of pain, including neuropathic pain. Summary of Literature Review: The neurophysiology of pain has been established at the cellular and molecular biology level throughmany studies. Also, multiple modalities to manage pain have been developed. Materials and Methods: A literature review. Results: Pain develops by actions of multiple receptors, ion channels and neurotransmitters along the pain pathway. Pathologic states,such as persistent pain, allodynia, and hyperalgesia, arise from alteration of the pain pathway. Especially, neuropathic pain results fromnerve injury and its pathology is rather different from the neuroplasty of normal individuals. Conclusion: Multiple modalities, including individualized pain treatment based on pain phenotype, are introduced. However, optimaltreatment is uncertain, therefore, further studies are needed.

KEYWORDS

Pathways of pain, Neuroplasticity, Neuropathic pain

Citation status

* References for papers published after 2023 are currently being built.

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