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Preparation and Biocompatibility of Medical Fiber from Novel Regenerated Cellulose from Styela clava tunic

  • Textile Coloration and Finishing
  • Abbr : Text. Color. and Finish.
  • 2018, 30(2), pp.117-129
  • DOI : 10.5764/TCF.2018.30.2.117
  • Publisher : The Korean Society Of Dyers And Finishers
  • Research Area : Engineering > Fiber Engineering > Dyeing Engineering
  • Received : March 15, 2018
  • Accepted : April 30, 2018
  • Published : June 27, 2018

Sung Hwa Song 1 Ji Eun Kim 1 Jun Young Choi 1 Jin Ju Park 1 Mi Rim Lee 1 Bo Ram Song 1 Yechan Lee 1 Kim, Hong Sung 1 Lee Jae Ho 1 Yong Lim 2 Hwang, Dae-Youn 1 Young Jin Jung 1

1부산대학교 바이오소재과학과
2동의대학교 임상병리학과

Accredited

ABSTRACT

Cellulose has been widely applied into various medical fields including scaffolding, tissue engineering and tissue formation. In this study, we manufactured cellulose medical fiber from Styela clava tunics(SCT-CS) and analyzed the tensile strength, elongation at break, fluid uptake and surface morphology. And then, the biocompatibility and toxicity of SCT-CS were measured in Sprague-Dawley(SD) rats after the implantation for 30, 60 and 90 days. The level of tensile strength and fluid uptake were lower in SCT-CS than chromic catgut(CCG), while elongation at break level were maintained the higher in SCT-CS. Also, the roughness with pronounced surface patterns as a result of in vivo degradation was significantly greater in CCG than this of SCT-CS although these levels gradually appeared with time in both groups. After implantation for 90 days, SCT-CS and CCG was successfully implanted around muscle of thigh without any significant immune response. Furthermore, no significant alterations were measured in serum parameters and the specific pathological features induced by most toxic compounds for liver and kidney toxicity. Therefore, these results suggest that SCT-CS showing good biocompatibility and non-toxicity can be successfully prepared from cellulose powder of SCT as well as has the potential for use as a powerful biomaterial for medical sutures.

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