Effect of Low Frequency Electrical Stimulation on VEGF Expression of Suspension Induced Atrophic Muscle (뒷다리 현수 유도 위축근에 대한 저빈도 전기자극의 VEGF 발현에 미치는 영향 )

강종호; Jong-man Han (한종만)

Effect of Low Frequency Electrical Stimulation on VEGF Expression of Suspension Induced Atrophic Muscle

Journal of the Korean Society of Physical Medicine
Abbr : J Korean Soc Phys Med
2010, 5(2), pp.273~280
Publisher : The Korean Society of Physical Medicine
Research Area : Medicine and Pharmacy > Physical Therapy > Other physical therapy

강종호 ¹, Jong-man Han ²

¹남부대학교
²전남과학대학

Candidate

ABSTRACT

Purpose：The purpose of this experiment was to evaluate the pre-application effect of low frequency electrical stimulation(LFES) on VEGF expression of atrophic muscle and to determine the optimal pre-application period of LFES for prevent muscle atropy Methods：Twenty-five adult sprague-dawley rats were randomly assigned to weight bearing group, hindlimb suspension for 14 days group, hindlimb suspension with pre-application of LFES for 14 days group, hindlimb suspension with pre-application of LFES for 11 dsys group and, hindlimb suspension with pre-application LFES for 7 dsys group. 16Hz of Biphasic pulse current was applied to gastrocnemius for 15min per days. Results：VEGF were decreased expression in HSG groups, whereas VEGF were significantly increased in HS+ES14G, HS+ES11G, HS+ES7G groups Conclusion：LFES during the hindlimb suspension showed a positive effect in VEGF induction and early application is strongly encourage VEGF induction. This indicated that pre-application of LFES could prevent muscle atrophy.

KEYWORDS

Muscle atrophy, Low frequency electrical stimulation, Vascular endothelial growth factor

Citation status

* References for papers published after 2023 are currently being built.

[thesis] 남기원 / 2003 / 신경근전기자극과 수중운동이 흰쥐 위축근 신경근연접부의 연접재형성에 미치는 영향 / 박사 / 대구대학교

[journal] Appell HJ / 1997 / Supplementation of vitamin E may attenuate skeletal muscle immobilization atrophy / Int J Sports Med 18(3) : 157~160

[journal] Ashley Z / 2007 / Effects of chronic electrical stimulation on long-term denervated muscles of the rabbit hind limb / J Muscle Res Cell Motil 28(4) : 203~207

[journal] Baldwin KM / 2002 / Skeletal Muscle Plasticity. Cellular and Molecular Responses to Altered Physical Activity Paradigms / Am J Phys Med Rehabil 81 : 40~51

[journal] Bayol S / 2005 / Electrical stimulation modulates IGF binding protein transcript levels in C2C12 myotubes / Cell Biochem. Funct 23(5) : 361~365

[journal] Boonyarom O / 2006 / Atrophy and hypertrophy of skeletal muscles: structural and functional aspects / Acta Physiol 188(2) : 77~89

[journal] Borisov AB / 2000 / Remodeling of the vascular and progressive loss of capillaries in denervated skeletal muscle / Anat Rec 258(3) : 292~304

[journal] Brown M / 2005 / Prehabilitation and rehabilitation for attenuating hindlimb unweighting effects on skeletal muscle and gait in adult and old rats / Arch Physic Med and Rehab 86(12) : 2261~2269

[journal] Bruno C / 2005 / Hindlimb unweighting for 2 weeks alters physiological properties of rat hindlimb motoneurones / J Physiol 568(3) : 841~850

[journal] Canton F / 1995 / Effects of chronic low frequency stimulation on structural and metabolic properties of hindlimb suspended rat soleus muscle / Eur J Appl Physiol. Occup.Physiol 70(6) : 528~535

[journal] D'Antona G / 2006 / Skeletal muscle hypertrophy and structure and function of skeletal muscle fibres in male body builders / J Physiol 570(3) : 611~627

[journal] Desaphy JF / 2005 / Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile / Neurobiol Dis 18(2) : 356~365

[journal] Dupont Salter AC / 2003 / Prevention of muscle disuse atrophy by low-frequency electrical stimulation in rats / IEEE Trans Neural Syst Rehabil Eng 11(3) : 218~226

[journal] Ground MD / 1991 / Towards understanding skeletal muscle regeneration / Path Res and Prac 187(1) : 1~22

[journal] Huang EJ / 2001 / Neurotrophins: Roles in neuronal development and function / Ann Rev Neurosci 24 : 677~736

[journal] Hudlicka O / 2003 / The effect of chronic skeletal muscle stimulation on capillary growth in the rat: are sensory nerve fibres involved? / J Physiol 546 : 813~822

[journal] Hurst JE / 2003 / Hindlimb unloading-induced muscle atrophy and loss of function: protective effect of isometric exercise / J Appl Physiol 95 : 1405~1417

[journal] Jørgensen L / 2000 / Ambulatory level and asymmetrical weight bearing after stroke affects bone loss in the upper and lower part of the femoral neck differently: bone adaptation after decreased mechanical loading / Bon 27(5) : 701~707

[journal] Kano / 2000 / Changes in capillary luminal diameter in rat soleus muscle after hind-limb suspension / Acta Physiol Scand 169 : 271~276

[journal] Kondo H / 1994 / Hydroxyl radical generation in skeletal muscle atrophied by immobilization / FEBS Lett 349 : 169~172

[journal] Krawiec BJ / 2005 / Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis / Am J Physiol Endocrinol Metab 289 : 969~980

[journal] Lynch GS / 2007 / Therapeutic approaches for muscle wasting disorders / Pharmacol Ther 113(3) : 461~487

[journal] Meredith HW / 2005 / The neuromuscular junction: anatomical features and adapotation to various forms of increased, or decreased neuromuscular activity / Int J Neurosci 115(6) : 803~828

[journal] Nagasaka M / 2006 / Effect of low-voltage electrical stimulation on angiogenic growth factors in ischaemic rat skeletal muscle / Clin Exp Pharmacol Physiol 33(7) : 623~627

[journal] Nemirovskaia TL / 2005 / Effects of long-term hypergravitation on the skeletal muscular tissue in rats / Ross Fiziol Zh Im I M Sechenova 91(2) : 113~121

[journal] Paddon-Jones D / 2006 / Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress / J Clin Endocrinol Metab 91(12) : 4836~4841

[journal] Qin L / 1997 / Electrical stimulation prevents immobilization atrophy in skeletal muscle of rabbits / Arch Phys Med Rehabil 78(5) : 512~517

[journal] Roberts D / 1989 / Biochemical aspects of peripheral muscle fatigue / Sports Med 17 : 125~138

[journal] Sandara L / 2001 / Angiogenesis Induced by Electrical Stimulation Is Mediated by Angiotensin II and VEGF / Microcirculation 8 : 57~67

[journal] Shimada Y / 2006 / Effects of therapeutic magnetic stimulation on acute muscle atrophy in rats after hindlimb suspension / Biomed Res 27(1) : 23~27

[journal] Strasser EM / 2009 / Neuromuscular electrical stimulation reduces skeletal muscle protein degradation and stimulates insulin-like growth factors in an age- and current-dependent manner: a randomized, controlled clinical trial in major abdominal surgical patients / Ann Surg 249(5) : 738~743

[journal] Thompson LV / 1998 / Single soleus muscle fiber function after hindlimb unweighting in adult and aged rats / J Appl Physiol 84 : 1937~1942

[journal] Wagatsuma A / 2006 / Sequential expression of vascular endothelial growth factor, Flt-1, and KDR/Flk-1 in regenerating mouse skeletal muscle / Physiol Res 55(6) : 633~640

[journal] Xu JG / 2003 / Effect of electric stimulation on denervated skeletal muscle atrophy / Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 17(5) : 96~99

[journal] Yumi K / 2008 / Preventive effect of isometric contraction exercise on disuse muscle atrophy using tail suspension mice / J Phys Ther Sci (20) : 39~44

KJCKorea
Journal Central

Journal of the Korean Society of Physical Medicine 2023 KCI Impact Factor : 0.45