Effects of Motor Skill Learning on Balance and Coordination in Excitoxicity Induced Cerebellar Injury Model of Rat ( 흥분독성 소뇌손상 백서모델에서 운동기술학습이 균형 및 협응력에 미치는 영향 )

김기도; 민경옥; 김용억; Kyung-Yoon Kim (김경윤); Kim Gye Yeop (김계엽); 심기철; Kim Eun Jung (김은정); Nam Ki Won (남기원); 심재환; 정재영

Effects of Motor Skill Learning on Balance and Coordination in Excitoxicity Induced Cerebellar Injury Model of Rat

Journal of the Korean Society of Physical Medicine
Abbr : J Korean Soc Phys Med
2010, 5(3), pp.455-465
Publisher : The Korean Society of Physical Medicine
Research Area : Medicine and Pharmacy > Physical Therapy > Other physical therapy

김기도 ¹, 민경옥 ², 김용억 ³, Kyung-Yoon Kim ³, Kim Gye Yeop ³, 심기철 ⁴, Kim Eun Jung ³, Nam Ki Won ³, 심재환 ⁵, 정재영 ⁵

¹동신대학교 물리치료학과
²용인대학교
³동신대학교
⁴동신대학교 대학원 물리치료 전공
⁵서강정보대학

Candidate

ABSTRACT

Purpose：This study is intended to examine the motor skill learning on balance and coordination in the cerebellar injured rats by 3AP. Methods：This study selected 60 Sprague-Dawley rats of 8 weeks. Experiment groups were divided into four groups and assigned 15 rats to each group. Group Ⅰ was a normal control group(induced by saline); Group Ⅱwas a experimental control group(cerebellar injured by 3AP); Group Ⅲ was a group of motor skill learning after cerebellar injured by 3AP; Group Ⅳ was a group of treadmill exercise after cerebellar injured by 3AP. In each group, motor performance test, histologic observations, synaptophysin expression and electron microscopy observation were analyzed. Results：In motor performance test, the outcome of group Ⅱ was significantly lower than the group Ⅲ, Ⅳ(especially group Ⅲ)(p<.001). In histological finding, the experimental groups were destroy of dendrities and nucleus of cerebellar neurons. Group Ⅲ, Ⅳ were decreased in degeneration of cerebellar neurons(especially group Ⅲ). In immunohistochemistric response of synaptophysin in cerebellar cortex, experimental groups were decreased than group Ⅰ. Group Ⅲ's expression of synaptophysin was more increased than group Ⅱ, Ⅳ. In electron microscopy finding, the experimental groups were degenerated of Purkinje cell. Conclusion：These result suggest that improved motor performance by motor skill learning after harmaline induced is associated with dynamically altered expression of synaptophysin in cerebellar cortex and that is related with synaptic plasticity.

KEYWORDS

Cerebellar, 3AP, Motor performance, Motor skill learning, Synaptic plasticity

Citation status

* References for papers published after 2023 are currently being built.

[journal] Anastasio TJ / 2001 / A pattern correlation model of vestibulo-ocular reflex habituation / Neural Netw 14(1) : 1~22

[journal] Anderson BJ / 1996 / Motorskill learning: changes in synaptic organization of the rat cerebellar cortex / Neurobiol Learn Mem 66(2) : 221~229

[journal] Anderson WA / 1980 / A light and electron microscopic study of the effects of 3-acetylpyridine intoxication on the inferior olivary complex and cerebellar cortex / J Comp Neurol 90(1) : 157~174

[journal] Beitz AJ / 2004 / Harmaline-induced climbing fiber activation causes amino acid and peptide release in the rodent cerebella cortex and a unique temporal pattern of Fos expression in the olivo-cerebellar pathway / J Neurocytol 33(1) : 49~74

[journal] Benson DL / 2000 / Making memories stick: cell-adhesion molecules in synaptic plasticity / Trends Cell Biol 10(11) : 473~482

[journal] Carro E / 2001 / Circulating insulin-like growth factor Ⅰ mediates the protective effects of physical exercise against brain insults of different etiology and anatomy / J Neurosci 21(15) : 5678~5684

[journal] Cotman CW / 2002 / Exercise: a behavioral intervention to enhance brain health and plasticity / Trends Neurosci 25(6) : 295~301

[journal] Cui W / 2001 / Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain / Glia 34(4) : 272~282

[journal] Desclin JC / 1980 / The olivocerebellar system. Ⅱ. Some ultrastructural correlates of inferior olive destruction in the rat / Brain Res 187(1) : 29~46

[journal] Devi SA / 2004 / response in antioxidant system to exercise training and dietary vitamin E in aging rat brain / Neurobiol Aging 25(4) : 501~508

[journal] Doble A / 1999 / The role of excitotoxicity in neurodegenerative disease: Implication for therapy / Pharmacol Ther 81(3) : 163~221

[journal] Federmeier KD / 2002 / Learninginduced multiple synapse formation in rat cerebellar cortex / Neurosci Lett 332(3) : 180~184

[journal] Fernandez-Chacon R / 2001 / Synaptotagmin Ⅰ functions as a calcium regulator of release probability / Nature 410(6824) : 41~49

[journal] rick KM / 2003 / Enrichment enhances spatial memory and increase synaptophysin levels in aged female mice / Neurobiol Aging 24(4) : 615~626

[journal] Gasbarri A / 2003 / Comparative effects of lesions to the ponto-cerebellar and olivocerebellar pathways on motor and spatial learning in the rat / Neuroscience 116 : 1131~1140

[journal] Giaquinta G / 1998 / Spinocerebellar Purkinje cell and rat forelimb postures: a direction-dependent activity / Neurosci Lett 245(2) : 81~84

[journal] Hollmann M / 1994 / Cloned glutamate receptors / Annu Rev Neurosci 17 : 31~108

[journal] Janahmadi M / 2009 / Co-treatment with riluzole, a neuroprotective drug, ameliorates the 3-acetylpyrine-induced neurotoxicity in cerebellar Purkinje neurons of rats: behavioral and electrophysiological evidence / Neurotoxicology 30(3) : 393~402

[journal] Javitt DC / 2007 / Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamineglutamate interactions / Int Rev Neurobiol 78 : 69~108

[journal] Jones TA / 1999 / Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats / J Neurosci 19(22) : 10153~10163

[journal] Kleim JA / 1998 / Selective synaptic plasticity within the cerebellar cortex following complex motor skill learning / Neurobiol Learn Mem 69(3) : 274~289

[journal] Kleim JA / 2007 / Motor learning induces astrocytic hypertrophy in the cerebellar cortex / Behav Brain Res 178(2) : 244~249

[journal] Laurin D / 2001 / Physical activity and risk of cognitive impairment and dementia in elderly persons / Arch Neurol 58(3) : 498~504

[journal] Light KE / 2002 / Ethanolinduced alterations of neurotrophin receptor expression on Purkinje cells in the neonatal rat cerebellum / Brain Res 924(1) : 71~81

[journal] Litwak J / 1990 / Increased glutamic acid decarboxylase(GAD) mRNA and GAD activity in cerebellar Purkinje cell following lesions-induced increased in cell firing / Neurosci Lett 116(1) : 179~183

[journal] Luscher C / 2000 / Synaptic plasticity and dynamic modulation of the postsynaptic membrane / Nat Neurosci 3(6) : 545~550

[journal] Mauk MD / 2000 / Cerebellar function: coordination, learning or timing? / Curr Biol 10(14) : 522~525

[journal] Morton SM / 2004 / Cerebellar control of balance and locomotion / Neuroscientist 10(3) : 247~259

[journal] Newlands SD / 2003 / Central projections of the vestibular nerve: a review and single fiber study in the Mongolian gerbil / Brain Res Bull 60(5) : 475~495

[journal] Perciavalle V / 1995 / Correlated activity in the spinocerebellum is related to spinal timing generators / Brain Res 695(2) : 293~297

[journal] Prins ML / 2003 / The effects of combined fluid percussion traumatic brain injury and unilateral entorhinal deafferentation on the juvenile rat brain / Brain Res Dev Brain Res 140(1) : 93~104

[journal] Rema V / 1999 / Effect of enriched environment rearing on impairments in cortical excitability and plasticity after prenatal alcohol exposure / J Neurosci 19(24) : 10993~11006

[journal] Remple MS / 2001 / Sensitivity of cortical movement representations to motor experience: evidence that skill learning but not strength training induces cortical reorganization / Behav Brain Res 123(2) : 133~141

[journal] Sanes JN / 2003 / Neocortical mechanisms in motor learning / Curr Opin Neurobiol 13(2) : 225~231

[journal] Seoane A / 2005 / Differential effects of trans-crotononitrile and 3-acetylpyridine on inferior olive integrity and behavioral performance in the rat / Eur J Neurosci 22(4) : 880~894

[journal] Sotelo C / 1994 / Molecular plasticity of adult Bergmann fibers is associated with radial migration of grafted Purkinje cells / J Neurosci 14(1) : 124~133

[journal] Steward O / 2002 / Local synthesis of proteins at synaptic sites on dendrites: role in synaptic plasticity and memory consolidation? / Neurobiol Learn Mem 78(3) : 508~527

[journal] Traystman RJ / 2003 / Animal models of focal and global cerebral ischemia / ILAR J 44(2) : 85~95

[journal] van-Praag H / 2000 / Neural consequences of environmental enrichment / Nat Rev Neurosci 1(3) : 191~198

[journal] Vaynman S / 2006 / Coupling energy metabolism with a mechanism to support brainderived neurotrophic factor-medicated synaptic plasticity / Neuroscience 139(4) : 1221~1234

[journal] Watson M / 1984 / Cerebellar norepinephrine depletion and impaired acquisition of specific locomotor tasks in the rats / Brain Res 296(1) : 129~138

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Journal of the Korean Society of Physical Medicine 2023 KCI Impact Factor : 0.45