Journal of the Korean Society of Physical Medicine 2023 KCI Impact Factor : 0.45
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pISSN : 1975-311X / eISSN : 2287-7215
- https://journal.kci.go.kr/kspm
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Effects of Repetitive Transcranial Magnetic Stimulation on Enhancement of Cognitive Function in Focal Ischemic Stroke Rat Model
- Journal of the Korean Society of Physical Medicine
- Abbr : J Korean Soc Phys Med
- 2012, 7(1), pp.11-20
- Publisher : The Korean Society of Physical Medicine
- Research Area : Medicine and Pharmacy > Physical Therapy > Other physical therapy
이정인 1, Kim Gye Yeop 2, Nam Ki Won 2, leedongwoo 3, Kim Gi Do 4, Kyung-Yoon Kim 2
1동신대 목포한방병원 물리치료실
2동신대학교
3광주중앙병원
4한국국제대학교
Candidate
ABSTRACT
Purpose：This study is intended to examine the repetitive transcranial magnetic stimulation on cognitive function in the focal ischemic stroke rat model.
Methods：This study selected 30 Sprague-Dawley rats of 8 weeks. The groups were divided into two groups and assigned 15 rats to each group. Control group: Non-treatment after injured by focal ischemic stroke;Experimental group: application of repetitive transcranial magnetic stimulation(0.1 Tesla, 25 ㎐, 20 min/time, 2times/day, 5 days/2 week) after injured by focal ischemic stroke. To assess the effect of rTMS, the passive avoidance test, spatial learning and memory ability test were analyzed at the pre, 1 day, 7th day, 14th day and immunohistochemistric response of BDNF were analyzed in the hippocampal dentate gyrus at 7th day, 14th day.
Results：In passive avoidance test, the outcome of experimental group was different significantly than the control group at the 7th day, 14th day. In spatial learning and memory ability test, the outcome of experimental group was different significantly than the control group at the 7th day, 14th day. In immunohistochemistric response of BDNF in the hippocampal dentate gyrus, experimental groups was more increased than control group.
Conclusion：These result suggest that improved cognitive function by repetitive transcranial magnetic stimulation after focal ischemic stroke is associated with dynamically altered expression of BDNF in hippocampal dentate gyrus and that is related with synaptic plasticity.
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