@article{ART001641201},
author={이정인 and Kim Gye Yeop and Nam Ki Won and leedongwoo and Kim Gi Do and Kyung-Yoon Kim},
title={Effects of Repetitive Transcranial Magnetic Stimulation on Enhancement of Cognitive Function in Focal Ischemic Stroke Rat Model},
journal={Journal of the Korean Society of Physical Medicine},
issn={1975-311X},
year={2012},
volume={7},
number={1},
pages={11-20}
TY - JOUR
AU - 이정인
AU - Kim Gye Yeop
AU - Nam Ki Won
AU - leedongwoo
AU - Kim Gi Do
AU - Kyung-Yoon Kim
TI - Effects of Repetitive Transcranial Magnetic Stimulation on Enhancement of Cognitive Function in Focal Ischemic Stroke Rat Model
JO - Journal of the Korean Society of Physical Medicine
PY - 2012
VL - 7
IS - 1
PB - The Korean Society of Physical Medicine
SP - 11
EP - 20
SN - 1975-311X
AB - Purpose:This study is intended to examine the repetitive transcranial magnetic stimulation on cognitive function in the focal ischemic stroke rat model.
Methods:This study selected 30 Sprague-Dawley rats of 8 weeks. The groups were divided into two groups and assigned 15 rats to each group. Control group: Non-treatment after injured by focal ischemic stroke;Experimental group: application of repetitive transcranial magnetic stimulation(0.1 Tesla, 25 ㎐, 20 min/time, 2times/day, 5 days/2 week) after injured by focal ischemic stroke. To assess the effect of rTMS, the passive avoidance test, spatial learning and memory ability test were analyzed at the pre, 1 day, 7th day, 14th day and immunohistochemistric response of BDNF were analyzed in the hippocampal dentate gyrus at 7th day, 14th day.
Results:In passive avoidance test, the outcome of experimental group was different significantly than the control group at the 7th day, 14th day. In spatial learning and memory ability test, the outcome of experimental group was different significantly than the control group at the 7th day, 14th day. In immunohistochemistric response of BDNF in the hippocampal dentate gyrus, experimental groups was more increased than control group.
Conclusion:These result suggest that improved cognitive function by repetitive transcranial magnetic stimulation after focal ischemic stroke is associated with dynamically altered expression of BDNF in hippocampal dentate gyrus and that is related with synaptic plasticity.
KW - Focal ischemic stroke;rTMS;Cognitive function;BDNF
DO -
UR -
ER -
이정인, Kim Gye Yeop, Nam Ki Won, leedongwoo, Kim Gi Do and Kyung-Yoon Kim. (2012). Effects of Repetitive Transcranial Magnetic Stimulation on Enhancement of Cognitive Function in Focal Ischemic Stroke Rat Model. Journal of the Korean Society of Physical Medicine, 7(1), 11-20.
이정인, Kim Gye Yeop, Nam Ki Won, leedongwoo, Kim Gi Do and Kyung-Yoon Kim. 2012, "Effects of Repetitive Transcranial Magnetic Stimulation on Enhancement of Cognitive Function in Focal Ischemic Stroke Rat Model", Journal of the Korean Society of Physical Medicine, vol.7, no.1 pp.11-20.
이정인, Kim Gye Yeop, Nam Ki Won, leedongwoo, Kim Gi Do, Kyung-Yoon Kim "Effects of Repetitive Transcranial Magnetic Stimulation on Enhancement of Cognitive Function in Focal Ischemic Stroke Rat Model" Journal of the Korean Society of Physical Medicine 7.1 pp.11-20 (2012) : 11.
이정인, Kim Gye Yeop, Nam Ki Won, leedongwoo, Kim Gi Do, Kyung-Yoon Kim. Effects of Repetitive Transcranial Magnetic Stimulation on Enhancement of Cognitive Function in Focal Ischemic Stroke Rat Model. 2012; 7(1), 11-20.
이정인, Kim Gye Yeop, Nam Ki Won, leedongwoo, Kim Gi Do and Kyung-Yoon Kim. "Effects of Repetitive Transcranial Magnetic Stimulation on Enhancement of Cognitive Function in Focal Ischemic Stroke Rat Model" Journal of the Korean Society of Physical Medicine 7, no.1 (2012) : 11-20.
이정인; Kim Gye Yeop; Nam Ki Won; leedongwoo; Kim Gi Do; Kyung-Yoon Kim. Effects of Repetitive Transcranial Magnetic Stimulation on Enhancement of Cognitive Function in Focal Ischemic Stroke Rat Model. Journal of the Korean Society of Physical Medicine, 7(1), 11-20.
이정인; Kim Gye Yeop; Nam Ki Won; leedongwoo; Kim Gi Do; Kyung-Yoon Kim. Effects of Repetitive Transcranial Magnetic Stimulation on Enhancement of Cognitive Function in Focal Ischemic Stroke Rat Model. Journal of the Korean Society of Physical Medicine. 2012; 7(1) 11-20.
이정인, Kim Gye Yeop, Nam Ki Won, leedongwoo, Kim Gi Do, Kyung-Yoon Kim. Effects of Repetitive Transcranial Magnetic Stimulation on Enhancement of Cognitive Function in Focal Ischemic Stroke Rat Model. 2012; 7(1), 11-20.
이정인, Kim Gye Yeop, Nam Ki Won, leedongwoo, Kim Gi Do and Kyung-Yoon Kim. "Effects of Repetitive Transcranial Magnetic Stimulation on Enhancement of Cognitive Function in Focal Ischemic Stroke Rat Model" Journal of the Korean Society of Physical Medicine 7, no.1 (2012) : 11-20.