@article{ART001798645},
author={Lee Jae Hyoung and Kwon Pil Seung and Seung-Joo Jekal},
title={Low-Intensity Pulsed Ultrasound Promotes Healing with Increases Collagen Deposition and Collagen mRNA Expression in Skin Wound of Rat},
journal={Journal of the Korean Society of Physical Medicine},
issn={1975-311X},
year={2013},
volume={8},
number={3},
pages={449-456}
TY - JOUR
AU - Lee Jae Hyoung
AU - Kwon Pil Seung
AU - Seung-Joo Jekal
TI - Low-Intensity Pulsed Ultrasound Promotes Healing with Increases Collagen Deposition and Collagen mRNA Expression in Skin Wound of Rat
JO - Journal of the Korean Society of Physical Medicine
PY - 2013
VL - 8
IS - 3
PB - The Korean Society of Physical Medicine
SP - 449
EP - 456
SN - 1975-311X
AB - 목적: 본 연구는 저강도 맥동 초음파적용이 흰쥐의 전층상처 치유와 아교질 축적 및 아교질 mRNA발현에 미치는 영향을 규명할 목적으로 시행하였다.
방법: 12마리의 Sprague-Dawley계 흰쥐를 저강도 맥동초음파군 (n=6)과 대조군 (n=6)에 무작위 배정하고 등에19.63 ㎟ 크기의 전층 적출 상처를 만든 다음 저강도 맥동초음파군은 3 MHz, 순환주기 20%, SATA 강도 0.4 W/㎠로 1일 1회, 1회 5분씩 초음파를 적용하고, 대조군은 가짜초음파를 적용하였다. 7일간 처치 후 초음파군과 대조군의 아교질 축적, 아교질 mRNA 발현, 상처치유율, 절반치유시간을 비교하였다.
결과 : 초음파군의 아교질 축적 (p<05)과 아교질 mRNA발현 (p<.01)이 대조군보다 유의하게 증가하였고, 상처치유율 (p<.05)과 절반치유시간 (p<.01)도 초음파군의 대조군보다 유의하게 빨랐다.
결론: 본 연구에서 전층 상처에 저강도 맥동 초음파를 적용한 결과 상처 치유가 촉진되었고 육아조직에 아교질축적이 증가하였다. 이러한 결과는 맥동 초음파의 기계적 자극이 제 1형 아교질 mRNA 전사활동을 촉진시키는것으로 사료된다.
KW - Low-intensity pulsed ultrasound;Wound healing;Collagen deposition;Collagen mRNA expression
DO -
UR -
ER -
Lee Jae Hyoung, Kwon Pil Seung and Seung-Joo Jekal. (2013). Low-Intensity Pulsed Ultrasound Promotes Healing with Increases Collagen Deposition and Collagen mRNA Expression in Skin Wound of Rat. Journal of the Korean Society of Physical Medicine, 8(3), 449-456.
Lee Jae Hyoung, Kwon Pil Seung and Seung-Joo Jekal. 2013, "Low-Intensity Pulsed Ultrasound Promotes Healing with Increases Collagen Deposition and Collagen mRNA Expression in Skin Wound of Rat", Journal of the Korean Society of Physical Medicine, vol.8, no.3 pp.449-456.
Lee Jae Hyoung, Kwon Pil Seung, Seung-Joo Jekal "Low-Intensity Pulsed Ultrasound Promotes Healing with Increases Collagen Deposition and Collagen mRNA Expression in Skin Wound of Rat" Journal of the Korean Society of Physical Medicine 8.3 pp.449-456 (2013) : 449.
Lee Jae Hyoung, Kwon Pil Seung, Seung-Joo Jekal. Low-Intensity Pulsed Ultrasound Promotes Healing with Increases Collagen Deposition and Collagen mRNA Expression in Skin Wound of Rat. 2013; 8(3), 449-456.
Lee Jae Hyoung, Kwon Pil Seung and Seung-Joo Jekal. "Low-Intensity Pulsed Ultrasound Promotes Healing with Increases Collagen Deposition and Collagen mRNA Expression in Skin Wound of Rat" Journal of the Korean Society of Physical Medicine 8, no.3 (2013) : 449-456.
Lee Jae Hyoung; Kwon Pil Seung; Seung-Joo Jekal. Low-Intensity Pulsed Ultrasound Promotes Healing with Increases Collagen Deposition and Collagen mRNA Expression in Skin Wound of Rat. Journal of the Korean Society of Physical Medicine, 8(3), 449-456.
Lee Jae Hyoung; Kwon Pil Seung; Seung-Joo Jekal. Low-Intensity Pulsed Ultrasound Promotes Healing with Increases Collagen Deposition and Collagen mRNA Expression in Skin Wound of Rat. Journal of the Korean Society of Physical Medicine. 2013; 8(3) 449-456.
Lee Jae Hyoung, Kwon Pil Seung, Seung-Joo Jekal. Low-Intensity Pulsed Ultrasound Promotes Healing with Increases Collagen Deposition and Collagen mRNA Expression in Skin Wound of Rat. 2013; 8(3), 449-456.
Lee Jae Hyoung, Kwon Pil Seung and Seung-Joo Jekal. "Low-Intensity Pulsed Ultrasound Promotes Healing with Increases Collagen Deposition and Collagen mRNA Expression in Skin Wound of Rat" Journal of the Korean Society of Physical Medicine 8, no.3 (2013) : 449-456.